MA53388A - Inhibiteurs d'inflammasome nlrp3 - Google Patents
Inhibiteurs d'inflammasome nlrp3Info
- Publication number
- MA53388A MA53388A MA053388A MA53388A MA53388A MA 53388 A MA53388 A MA 53388A MA 053388 A MA053388 A MA 053388A MA 53388 A MA53388 A MA 53388A MA 53388 A MA53388 A MA 53388A
- Authority
- MA
- Morocco
- Prior art keywords
- inflammasome
- nlrp3 inhibitors
- nlrp3
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18185580 | 2018-07-25 | ||
| EP19175246 | 2019-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA53388A true MA53388A (fr) | 2021-06-02 |
Family
ID=67989037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA053388A MA53388A (fr) | 2018-07-25 | 2019-07-23 | Inhibiteurs d'inflammasome nlrp3 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US12168012B2 (fr) |
| EP (1) | EP3827008B1 (fr) |
| JP (1) | JP7555327B2 (fr) |
| KR (1) | KR20210038877A (fr) |
| CN (1) | CN112424207B (fr) |
| AU (1) | AU2019309727B2 (fr) |
| BR (1) | BR112021000964A2 (fr) |
| CA (1) | CA3103943A1 (fr) |
| CL (1) | CL2021000191A1 (fr) |
| CO (1) | CO2021000537A2 (fr) |
| CR (1) | CR20210045A (fr) |
| CU (1) | CU20210009A7 (fr) |
| DO (1) | DOP2021000019A (fr) |
| EC (1) | ECSP21004787A (fr) |
| IL (1) | IL280336A (fr) |
| JO (1) | JOP20210017A1 (fr) |
| MA (1) | MA53388A (fr) |
| MX (1) | MX2021000925A (fr) |
| PE (1) | PE20210406A1 (fr) |
| PH (1) | PH12021550166A1 (fr) |
| SG (1) | SG11202012321PA (fr) |
| WO (1) | WO2020021447A1 (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021202305A1 (fr) * | 2020-03-31 | 2021-10-07 | Olatec Therapeutics Llc | Méthode de prévention ou de traitement d'une infection pulmonaire et d'une inflammation pulmonaire |
| CN115427110A (zh) | 2020-04-15 | 2022-12-02 | 詹森药业有限公司 | Nlrp3炎体途径抑制剂吡唑并[1,5-d][1,2,4]三嗪-5(4h)乙酰胺 |
| KR20230002652A (ko) | 2020-04-15 | 2023-01-05 | 얀센 파마슈티카 엔.브이. | NLRP3 인플라마좀 경로의 저해제로서의 피롤로[1,2-d][1,2,4]트리아진-2-일-아세트아미드 |
| CN115461345A (zh) | 2020-04-23 | 2022-12-09 | 詹森药业有限公司 | 作为nlrp3抑制剂的三环化合物 |
| JP2023523756A (ja) * | 2020-04-30 | 2023-06-07 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規なトリアジノインドール化合物 |
| CA3177672A1 (fr) | 2020-05-28 | 2021-12-02 | Michael Eric MURATORE | Composes |
| IL299084A (en) | 2020-06-19 | 2023-02-01 | Ac Immune Sa | History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway |
| CN116261456B (zh) * | 2020-08-14 | 2025-07-08 | 戴纳立制药公司 | 化合物、组合物和方法 |
| EP3974415A1 (fr) | 2020-09-24 | 2022-03-30 | Janssen Pharmaceutica NV | Nouveaux composés |
| CA3189887A1 (fr) * | 2020-09-24 | 2022-03-31 | Daniel Oehlrich | Nouveaux composes |
| CN114478537B (zh) * | 2020-11-13 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 环酰胺并环化合物及其医药用途 |
| MX2023005906A (es) * | 2020-11-20 | 2023-05-26 | Denali Therapeutics Inc | Compuestos, composiciones y metodos. |
| CN117083272A (zh) * | 2021-03-04 | 2023-11-17 | 詹森药业有限公司 | 调节nlrp3的4-烷氧基-6-氧代-哒嗪衍生物 |
| MX2023010223A (es) | 2021-03-04 | 2023-09-11 | Janssen Pharmaceutica Nv | Derivados de 4-amino-6-oxo-piridazina que modulan la nlrp3. |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| US11951115B2 (en) | 2021-04-13 | 2024-04-09 | Unity Biotechnology, Inc. | Methods of treating retinal vasculopathies |
| US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| MX2023012840A (es) * | 2021-04-29 | 2023-11-13 | Janssen Pharmaceutica Nv | Derivados de ftalazinona como inhibidores del inflamasoma nlrp3. |
| BR112023025318A2 (pt) | 2021-06-04 | 2024-02-27 | Hoffmann La Roche | Derivados de triazina e seu uso no tratamento do câncer |
| IL294231A (en) | 2021-06-23 | 2023-01-01 | Yoda Pharmaceuticals Inc | Benzimidazole derivatives for treatment and/or prevention of diseases and disorders mediated by nlrp3 |
| WO2023275230A1 (fr) | 2021-07-01 | 2023-01-05 | Janssen Pharmaceutica Nv | Acétamides 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl |
| US20240254132A1 (en) * | 2021-07-16 | 2024-08-01 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| WO2023028536A1 (fr) * | 2021-08-25 | 2023-03-02 | Ptc Therapeutics, Inc. | Dérivés de 1, 2, 4-triazine utiles en tant qu'inhibiteurs de nlrp3 |
| EP4401739A4 (fr) * | 2021-09-17 | 2025-07-30 | Nico Therapeutics Inc | Composés, compositions et procédés |
| KR20230066899A (ko) | 2021-11-08 | 2023-05-16 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| US20250109126A1 (en) | 2021-12-22 | 2025-04-03 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
| CN116375728B (zh) * | 2021-12-31 | 2025-06-10 | 成都赜灵生物医药科技有限公司 | 噻吩吡咯并三嗪酮类化合物及其用途 |
| WO2023158708A1 (fr) * | 2022-02-16 | 2023-08-24 | Denali Therapeutics Inc. | Composés, compositions et procédés |
| AU2023222186A1 (en) * | 2022-02-21 | 2024-10-10 | Sanofi | Thienopyrrolotriazine compounds, their preparation and their therapeutic use |
| EP4554945A1 (fr) | 2022-07-14 | 2025-05-21 | AC Immune SA | Dérivés de pyrrolotriazine et d'imidazotriazine utilisés en tant que modulateurs de la voie de l'inflammasome nlrp3 |
| CA3261365A1 (fr) | 2022-07-28 | 2024-02-01 | Ac Immune Sa | Nouveaux composés |
| EP4568975A1 (fr) * | 2022-08-10 | 2025-06-18 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique |
| KR20240022938A (ko) | 2022-08-12 | 2024-02-20 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| KR20250069659A (ko) | 2022-09-23 | 2025-05-19 | 머크 샤프 앤드 돔 엘엘씨 | Nod-유사 수용체 단백질 3의 억제제로서 유용한 프탈라진 유도체 |
| AU2024211840A1 (en) | 2023-01-24 | 2025-07-03 | Daiichi Sankyo Company, Limited | Substituted benzene compound |
| JP2026510921A (ja) * | 2023-03-17 | 2026-04-10 | ヴェンタス・セラピューティクス・ユー・エス・インコーポレイテッド | Ｎｌｒｐ３を阻害するためのアミド誘導体及びその使用 |
| EP4719599A1 (fr) | 2023-06-02 | 2026-04-08 | Merck Sharp & Dohme LLC | Hétérocyles bicycliques insaturés 5,6 utiles comme inhibiteurs de la protéine réceptrice de type nod 3 |
| KR20250030934A (ko) | 2023-08-25 | 2025-03-05 | 제일약품주식회사 | Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| AR134647A1 (es) | 2023-12-14 | 2026-02-04 | Merck Sharp & Dohme Llc | Derivados de azaindazol útiles como inhibidores de la proteína 3 del receptor similar a nod |
| WO2025128777A1 (fr) | 2023-12-14 | 2025-06-19 | Merck Sharp & Dohme Llc | Dérivés d'indazole utiles en tant qu'inhibiteurs de la protéine réceptrice de type nod 3 |
| WO2025133307A1 (fr) | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Modulateurs hétérocycliques de la voie de l'inflammasome nlrp3 |
| WO2025153532A1 (fr) | 2024-01-16 | 2025-07-24 | NodThera Limited | Polythérapies faisant intervenir des inhibiteurs de nlrp3 et des agonistes de glp-1 |
| WO2025153624A1 (fr) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Dérivés d'imidazo[1,2-d][1,2,4]triazine destinés à être utilisés en tant qu'inhibiteurs de la voie de l'inflammasome nlrp3 |
| WO2025153625A1 (fr) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Dérivés d'imidazo[1,2-d][1,2,4]triazine destinés à être utilisés en tant qu'inhibiteurs de la voie de l'inflammasome nlrp3 |
| WO2025163069A1 (fr) | 2024-01-31 | 2025-08-07 | Ac Immune Sa | Nouveaux composés |
| WO2026024770A1 (fr) * | 2024-07-23 | 2026-01-29 | New York Blood Center, Inc. | Composés pour traiter des maladies associées à l'hémolyse et à l'inflammasome |
| WO2026057747A1 (fr) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Utilisation thérapeutique de composés inhibiteurs de la voie de l'inflammasome nlrp3 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009008906A2 (fr) * | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Composés thérapeutiques pour un blocage de la synthèse d'adn de poxvirus |
| WO2010128152A1 (fr) | 2009-05-07 | 2010-11-11 | Novartis Ag | C-glycosides hétérocycliques condensés pour le traitement du diabète |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| KR20120087950A (ko) | 2009-10-20 | 2012-08-07 | 노파르티스 아게 | 글리코시드 유도체 및 그의 용도 |
| CA2803056C (fr) | 2010-06-23 | 2017-05-16 | Hanmi Science Co., Ltd. | Derives de pyrimidine fusionnes destines a l'inhibition de l'activite tyrosine kynase |
| CN105566229A (zh) | 2010-08-10 | 2016-05-11 | 西建阿维拉米斯研究公司 | Btk抑制剂的苯磺酸盐及其用途和制备方法 |
| CU24152B1 (es) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
| EA031153B1 (ru) | 2011-06-10 | 2018-11-30 | Мерк Патент Гмбх | Применение пиримидиновых соединений с btk ингибирующей активностью |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| DK2786996T3 (en) | 2011-11-29 | 2016-12-19 | Ono Pharmaceutical Co | Hydrochloride PURINONDERIVAT |
| EP2858500A4 (fr) | 2012-06-08 | 2016-04-06 | Biogen Ma Inc | Inhibiteurs de la tyrosine kinase de bruton |
| US9266895B2 (en) | 2012-09-10 | 2016-02-23 | Principia Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors |
| SG11201503697TA (en) | 2012-11-28 | 2015-06-29 | Intercept Pharmaceuticals Inc | Treatment of pulmonary disease |
| UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
| JO3377B1 (ar) | 2013-03-11 | 2019-03-13 | Takeda Pharmaceuticals Co | مشتقات بيريدينيل وبيريدينيل مندمج |
| SI2989106T1 (sl) | 2013-04-25 | 2017-07-31 | Beigene, Ltd. | Zlite heterociklične spojine kot inhibitorji beljakovinske kinaze |
| SG11201603026PA (en) | 2013-11-05 | 2016-05-30 | Novartis Ag | Compositions and methods for modulating farnesoid x receptors |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
| EA201691169A1 (ru) | 2013-12-05 | 2016-09-30 | Асерта Фарма Б.В. | Терапевтическая комбинация ингибитора pi3k и ингибитора btk |
| SI3083564T1 (sl) | 2013-12-20 | 2018-10-30 | Novartis Ag | Derivati heteroarilbutanojske kisline kot inhibitorji LTA4H |
| WO2015110923A2 (fr) | 2014-01-21 | 2015-07-30 | Acerta Pharma B.V. | Méthodes de traitement de la leucémie lymphoïde chronique et du lymphome à petits lymphocytes en utilisant un inhibiteur de btk |
| CA2935423C (fr) | 2014-01-24 | 2023-11-07 | Dana-Farber Cancer Institute, Inc. | Molecules d'anticorps anti-pd-1 et leurs utilisations |
| AU2015210750B2 (en) | 2014-01-31 | 2020-08-20 | Children's Medical Center Corporation | Antibody molecules to TIM-3 and uses thereof |
| WO2015138920A1 (fr) | 2014-03-14 | 2015-09-17 | Novartis Ag | Molécules d'anticorps anti-lag-3 et leurs utilisations |
| MY186570A (en) | 2014-05-13 | 2021-07-27 | Novartis Ag | Compounds and compositions for inducing chondrogenesis |
| WO2016061142A1 (fr) | 2014-10-14 | 2016-04-21 | Novartis Ag | Molécules d'anticorps de pd-l1 et leurs utilisations |
| AR102426A1 (es) | 2014-10-24 | 2017-03-01 | Bristol Myers Squibb Co | Compuestos de indolcarboxamida como inhibidores de btk |
| EP3236953B1 (fr) | 2014-12-24 | 2020-11-11 | Principia Biopharma Inc. | Dosage spécifique de site d'un inhibiteur de btk |
| EP3303334B1 (fr) | 2015-06-03 | 2021-06-02 | Principia Biopharma Inc. | Inhibiteurs de la tyrosine kinase |
| WO2016201280A1 (fr) | 2015-06-10 | 2016-12-15 | Biogen Ma Inc. | Formes et compositions d'inhibiteurs biaryles de la tyrosine kinase de bruton |
| WO2017059702A1 (fr) | 2015-10-09 | 2017-04-13 | Acea Biosciences, Inc | Sels pharmaceutiques, formes physiques, et compositions d'inhibiteurs pyrrolopyrimidine de kinases, et leurs procédés de préparation |
| SG11201802927VA (en) | 2015-11-04 | 2018-05-30 | Merck Patent Gmbh | Methods for treating cancer using pyrimidine and pyridine compounds with btk inhibitory activity |
| KR20220100719A (ko) | 2015-12-10 | 2022-07-15 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 또는 개선을 위한 조성물 |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| KR102688907B1 (ko) | 2016-01-05 | 2024-07-29 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Btk 키나아제 억제제의 결정질 형태 및 이의 제조 방법 |
| BR112018071347A2 (pt) * | 2016-04-19 | 2019-02-05 | Innate Tumor Immunity Inc | moduladores de nlrp3 |
| IL293621B2 (en) | 2016-06-29 | 2023-09-01 | Principia Biopharma Inc | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile |
| KR101865120B1 (ko) | 2016-06-29 | 2018-06-08 | 숭실대학교 산학협력단 | 테스트 노드 기반의 무선 측위 방법 및 그 장치 |
| EP3272739A1 (fr) | 2016-07-20 | 2018-01-24 | NodThera Limited | Derives de sulfonyluree et leur application en matiere de regulation de l'activite de l'interleukine-1 |
| GB201712282D0 (en) * | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| EP3668843A1 (fr) * | 2017-08-15 | 2020-06-24 | Inflazome Limited | Sulfonylurées et sulfonylthiourées utilisés en tant qu'inhibiteurs de nlrp3 |
| TW201910316A (zh) | 2017-08-15 | 2019-03-16 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
| PE20210050A1 (es) | 2017-11-09 | 2021-01-08 | Inflazome Ltd | Nuevos compuestos de sulfonamida carboxamida |
-
2019
- 2019-07-23 US US17/259,252 patent/US12168012B2/en active Active
- 2019-07-23 JO JOP/2021/0017A patent/JOP20210017A1/ar unknown
- 2019-07-23 PE PE2021000092A patent/PE20210406A1/es unknown
- 2019-07-23 SG SG11202012321PA patent/SG11202012321PA/en unknown
- 2019-07-23 KR KR1020217001895A patent/KR20210038877A/ko not_active Withdrawn
- 2019-07-23 MA MA053388A patent/MA53388A/fr unknown
- 2019-07-23 CU CU2021000009A patent/CU20210009A7/es unknown
- 2019-07-23 CA CA3103943A patent/CA3103943A1/fr active Pending
- 2019-07-23 BR BR112021000964-7A patent/BR112021000964A2/pt not_active Application Discontinuation
- 2019-07-23 EP EP19769892.1A patent/EP3827008B1/fr active Active
- 2019-07-23 CN CN201980047047.4A patent/CN112424207B/zh active Active
- 2019-07-23 CR CR20210045A patent/CR20210045A/es unknown
- 2019-07-23 AU AU2019309727A patent/AU2019309727B2/en not_active Ceased
- 2019-07-23 JP JP2021503752A patent/JP7555327B2/ja active Active
- 2019-07-23 WO PCT/IB2019/056278 patent/WO2020021447A1/fr not_active Ceased
- 2019-07-23 MX MX2021000925A patent/MX2021000925A/es unknown
-
2021
- 2021-01-21 PH PH12021550166A patent/PH12021550166A1/en unknown
- 2021-01-21 IL IL280336A patent/IL280336A/en unknown
- 2021-01-22 EC ECSENADI20214787A patent/ECSP21004787A/es unknown
- 2021-01-22 DO DO2021000019A patent/DOP2021000019A/es unknown
- 2021-01-22 CL CL2021000191A patent/CL2021000191A1/es unknown
- 2021-01-22 CO CONC2021/0000537A patent/CO2021000537A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3103943A1 (fr) | 2020-01-30 |
| WO2020021447A1 (fr) | 2020-01-30 |
| EP3827008B1 (fr) | 2024-07-31 |
| PH12021550166A1 (en) | 2021-09-13 |
| JP2021532124A (ja) | 2021-11-25 |
| JP7555327B2 (ja) | 2024-09-24 |
| CO2021000537A2 (es) | 2021-01-29 |
| US20210308140A1 (en) | 2021-10-07 |
| BR112021000964A2 (pt) | 2021-04-20 |
| IL280336A (en) | 2021-03-01 |
| AU2019309727A1 (en) | 2021-01-07 |
| JOP20210017A1 (ar) | 2021-01-21 |
| CR20210045A (es) | 2021-06-18 |
| PE20210406A1 (es) | 2021-03-02 |
| AU2019309727B2 (en) | 2021-12-23 |
| DOP2021000019A (es) | 2021-02-15 |
| KR20210038877A (ko) | 2021-04-08 |
| CN112424207B (zh) | 2024-03-19 |
| SG11202012321PA (en) | 2021-02-25 |
| CL2021000191A1 (es) | 2021-08-20 |
| CU20210009A7 (es) | 2021-08-06 |
| MX2021000925A (es) | 2021-03-31 |
| ECSP21004787A (es) | 2021-03-31 |
| US12168012B2 (en) | 2024-12-17 |
| CN112424207A (zh) | 2021-02-26 |
| EP3827008A1 (fr) | 2021-06-02 |
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