MA53939A - Compositions hémostatiques et leurs procédés de fabrication - Google Patents

Compositions hémostatiques et leurs procédés de fabrication

Info

Publication number
MA53939A
MA53939A MA053939A MA53939A MA53939A MA 53939 A MA53939 A MA 53939A MA 053939 A MA053939 A MA 053939A MA 53939 A MA53939 A MA 53939A MA 53939 A MA53939 A MA 53939A
Authority
MA
Morocco
Prior art keywords
making
methods
hemostatic compositions
hemostatic
compositions
Prior art date
Application number
MA053939A
Other languages
English (en)
Inventor
Shuang Chen
Dengmin Feng
Yufu Li
Xiang Wan
Original Assignee
Ethicon Inc
Guangzhou Bioseal Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc, Guangzhou Bioseal Biotech Co Ltd filed Critical Ethicon Inc
Publication of MA53939A publication Critical patent/MA53939A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA053939A 2016-08-15 2017-08-10 Compositions hémostatiques et leurs procédés de fabrication MA53939A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610666290.2A CN107754005B (zh) 2016-08-15 2016-08-15 止血组合物及其制造方法
US15/258,549 US11229720B2 (en) 2016-08-15 2016-09-07 Hemostatic compositions and methods of making thereof

Publications (1)

Publication Number Publication Date
MA53939A true MA53939A (fr) 2021-09-15

Family

ID=61159989

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053939A MA53939A (fr) 2016-08-15 2017-08-10 Compositions hémostatiques et leurs procédés de fabrication

Country Status (13)

Country Link
US (3) US11229720B2 (fr)
EP (2) EP3496769B1 (fr)
JP (1) JP6968870B2 (fr)
CN (1) CN107754005B (fr)
AU (1) AU2017311658B2 (fr)
BR (1) BR112019003015B1 (fr)
CA (1) CA3033932A1 (fr)
ES (1) ES2831854T3 (fr)
IL (1) IL264613B (fr)
MA (1) MA53939A (fr)
PL (1) PL3496769T3 (fr)
RU (1) RU2756891C2 (fr)
WO (1) WO2018033835A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034957B2 (en) 2015-11-06 2018-07-31 Ethicon Llc Compacted hemostatic cellulosic aggregates
US20220111020A1 (en) * 2016-08-15 2022-04-14 Guangzhou Bioseal Biotech Co. Ltd. Hemostatic compositions and methods of making thereof
US11413335B2 (en) * 2018-02-13 2022-08-16 Guangzhou Bioseal Biotech Co. Ltd Hemostatic compositions and methods of making thereof
CN107754005B (zh) 2016-08-15 2021-06-15 广州倍绣生物技术有限公司 止血组合物及其制造方法
BR112020011034A2 (pt) * 2017-12-29 2020-11-17 Baxter International Inc. trombina secada por pulverização e métodos para usar e fabricar trombina secada por pulverização
CN110732037B (zh) 2018-07-20 2023-05-26 广州倍绣生物技术有限公司 止血糊剂及其制备方法
CN112807481B (zh) * 2018-08-20 2022-07-26 稳得希林(杭州)生物科技有限公司 多糖基组织粘合医用胶及其应用
EP3934542B1 (fr) * 2019-03-06 2025-04-23 Gambro Lundia AB Dispositif et procédé de distribution d'un agent d'étanchéité à base de fibrine activé par la thrombine
WO2021109979A1 (fr) 2019-12-06 2021-06-10 Guangzhou Bioseal Biotech Co., Ltd. Pâte de thrombine fibrinogène fluide
US11826028B2 (en) * 2020-06-10 2023-11-28 Ethicon, Inc. Two component sealing systems including synthetic matrices and biosynthetic adhesives for sealing resected surfaces of organs to control bleeding, fluid leaks and air leaks
CN112972755B (zh) * 2021-03-25 2022-07-05 哈尔滨瀚邦医疗科技有限公司 一种基于猪源纤维蛋白原和凝血酶的生物止血材料的制备方法
WO2023196787A2 (fr) * 2022-04-04 2023-10-12 Vascudyne, Inc. Tissu construit amélioré
US20250032666A1 (en) * 2023-07-25 2025-01-30 Ethicon, Inc. Hemostatic Materials Based on Aldehyde-Functional Polysaccharides

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2517772A (en) * 1945-05-11 1950-08-08 Parke Davis & Co Neutralized oxidized cellulose products
US3364200A (en) 1960-03-28 1968-01-16 Johnson & Johnson Oxidized cellulose product and method for preparing the same
ATE20824T1 (de) * 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung.
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
US4626253A (en) 1984-10-05 1986-12-02 Johnson & Johnson Products, Inc. Surgical hemostat comprising oxidized cellulose
DK160809C (da) * 1989-01-09 1995-10-02 Niro Holding As Fremgangsmåde og forstøvningstørringsapparat til fremstilling af stabile partikelagglomerater
US5696191A (en) 1989-09-18 1997-12-09 Kimberly-Clark Worldwide, Inc. Surface-segregatable compositions and nonwoven webs prepared therefrom
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
US7208179B1 (en) * 1990-11-27 2007-04-24 The American National Red Cross Methods for treating disease and forming a supplemented fibrin matrix
US5180398A (en) 1990-12-20 1993-01-19 Johnson & Johnson Medical, Inc. Cellulose oxidation by a perfluorinated hydrocarbon solution of nitrogen dioxide
US6177126B1 (en) 1993-03-31 2001-01-23 Nycomed Arzneimittel Gmbh Process for the production of a material for sealing and healing wounds
ES2227542T3 (es) * 1993-11-03 2005-04-01 Clarion Pharmaceuticals, Inc. Parche hemostatico.
CZ288792B6 (cs) 1993-12-23 2001-09-12 Johnson & Johnson Medical, Inc. Bioabsorbovatelný chirurgický hemostat a způsob jeho výroby
WO1997028832A1 (fr) * 1996-02-06 1997-08-14 New Generation Medical Corporation Composition pour fermer les blessures
WO1997044015A1 (fr) * 1996-05-17 1997-11-27 Andaris Limited Microparticules et utilisation de ces dernieres pour soigner des plaies
GB2314842B (en) 1996-06-28 2001-01-17 Johnson & Johnson Medical Collagen-oxidized regenerated cellulose complexes
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
JP3287798B2 (ja) 1997-12-17 2002-06-04 レンゴー株式会社 球状セルロース微粒子の製造方法
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
JP3578627B2 (ja) 1998-05-15 2004-10-20 株式会社ホギメディカル 創傷患部の治癒を促進する組織シーラント
DE19849589C1 (de) 1998-10-27 2000-06-15 Glatt Process Technology Gmbh Fibrin-Gewebekleber-Formulierung und Verfahren zu dessen Herstellung
DE19859611C2 (de) * 1998-12-23 2003-07-03 Aventis Behring Gmbh Fibrinklebergranulat und Verfahren zu dessen Herstellung
AU754458B2 (en) 1998-12-23 2002-11-14 Csl Behring Gmbh Fibrin-based glue granulate and corresponding production method
GB2354708B (en) 1999-10-01 2004-06-02 Johnson & Johnson Medical Ltd Compositions for the treatment of wound contracture
US6627749B1 (en) 1999-11-12 2003-09-30 University Of Iowa Research Foundation Powdered oxidized cellulose
JP3576063B2 (ja) 2000-02-22 2004-10-13 株式会社ホギメディカル 凝固蛋白質を含む可溶性創傷治癒止血セルロース繊維とその製造方法
US6309454B1 (en) 2000-05-12 2001-10-30 Johnson & Johnson Medical Limited Freeze-dried composite materials and processes for the production thereof
US7094428B2 (en) 2000-06-16 2006-08-22 The University Of Medicine And Dentistry Of New Jersey Hemostatic compositions, devices and methods
US6733774B2 (en) 2001-01-25 2004-05-11 Nycomed Pharma As Carrier with solid fibrinogen and solid thrombin
US7052713B2 (en) 2001-02-13 2006-05-30 Nycomed Pharma As Carrier with solid fibrinogen and solid thrombin
US20030124087A1 (en) 2001-12-26 2003-07-03 Amitie Co. Ltd. Anti-adhesion barrier
US7279177B2 (en) 2002-06-28 2007-10-09 Ethicon, Inc. Hemostatic wound dressings and methods of making same
US20040101546A1 (en) 2002-11-26 2004-05-27 Gorman Anne Jessica Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents
EP1588722A4 (fr) 2003-01-20 2011-03-02 Chemo Sero Therapeut Res Inst Materiaux hemostatiques
RU2235539C1 (ru) * 2003-04-25 2004-09-10 Филатов Владимир Николаевич Способ получения порошкообразного материала для остановки кровотечений
CN1454667A (zh) * 2003-05-07 2003-11-12 徐振彪 使用方便的纤维蛋白封闭剂
US20040265371A1 (en) 2003-06-25 2004-12-30 Looney Dwayne Lee Hemostatic devices and methods of making same
US20070141156A1 (en) 2005-12-21 2007-06-21 Uri Herzberg Compositions and methods for preventing or reducing postoperative ileus and gastric stasis
DK1766003T3 (da) * 2004-06-22 2008-12-08 Zymogenetics Inc Thrombinpræparater
US9358318B2 (en) 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
US7749204B2 (en) 2004-10-20 2010-07-06 Ethicon, Inc. Reinforced absorbable multilayered fabric for use in tissue repair and regeneration
EP1809343B1 (fr) * 2004-10-20 2012-08-15 Ethicon, Inc. Pansement hemostatique multicouche absorbable renforce et son procede de fabrication
US20080027365A1 (en) 2006-06-01 2008-01-31 Huey Raymond J Hemostatic device with oxidized cellulose pad
WO2008117746A1 (fr) 2007-03-22 2008-10-02 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Préparation de fibrinogène solide
GB0811743D0 (en) 2008-06-26 2008-07-30 Hemosol Biopharma Inc Composition
AU2009327592B2 (en) 2008-12-19 2015-02-12 Essity Hygiene And Health Aktiebolag Superabsorbent polymer composite comprising a superabsorbent polymer and cellulosic nanofibrils
CN101716383A (zh) 2009-11-26 2010-06-02 贵州金玖生物技术有限公司 一种止血防粘连材料的制备方法
WO2011083154A1 (fr) 2010-01-08 2011-07-14 Profibrix Bv Adhésif de fibrine en poudre sèche
US8273369B2 (en) * 2010-05-17 2012-09-25 Ethicon, Inc. Reinforced absorbable synthetic matrix for hemostatic applications
US8329211B2 (en) 2010-05-17 2012-12-11 Ethicon, Inc. Reinforced absorbable multi-layered fabric for hemostatic applications
CN101890181B (zh) * 2010-06-12 2014-04-30 广州倍绣生物技术有限公司 一种猪源纤维蛋白胶粉雾剂及其制备方法和应用
RU2013155713A (ru) * 2011-07-06 2015-08-20 Профибрикс Бв Составы для лечения ран
WO2013056116A1 (fr) 2011-10-12 2013-04-18 The Trustees Of Columbia University In The City Of New York Pansement hémostatique pour saignement artériel
US9056092B2 (en) 2011-12-02 2015-06-16 Ethicon, Inc. Hemostatic bioabsorbable device with polyethylene glycol binder
DK2790758T3 (da) 2011-12-16 2017-11-20 Indosys Ltd Kassette til en lægemiddeldosis og tilførselsindretning
US9028851B2 (en) 2011-12-21 2015-05-12 Ethicon, Inc. Hemostatic materials and devices with galvanic particulates
US8815832B2 (en) 2012-05-25 2014-08-26 Ethicon, Inc. Oxidized regenerated cellulose hemostatic powders and methods of making
US9271937B2 (en) * 2012-05-31 2016-03-01 Covidien Lp Oxidized cellulose microspheres
EP2873243A1 (fr) 2012-06-29 2015-05-20 VID SCALE, Inc. Priorisation de trames basée sur des informations de prédiction
WO2014052213A1 (fr) 2012-09-25 2014-04-03 Dow Global Technologies Llc Procédé de production de dérivés de cellulose présentant une masse volumique apparente élevée, une bonne fluidité et/ou dispersibilité dans l'eau froide ainsi qu'une faible couleur en solution
WO2014077854A1 (fr) 2012-11-19 2014-05-22 Washington State University Research Foundation Matériaux de cellulose nanocristalline et procédés pour les préparer
KR101624625B1 (ko) * 2012-12-28 2016-05-26 주식회사 삼양바이오팜 개선된 흡수성 지혈제 및 그 제조방법
BR112015017463A8 (pt) * 2013-03-07 2017-11-28 Profibrix Bv Formulação em pó
US20140274944A1 (en) * 2013-03-15 2014-09-18 Covidien Lp Sprayable Hemostat Using Soluble Oxidized Cellulose With Miniaturized Electrospray System And Method
CN105555299B (zh) * 2013-04-22 2023-03-28 西兰丁姆医疗公司 纤维蛋白原基组织粘合剂贴片
RU2522980C1 (ru) 2013-05-24 2014-07-20 ОАО "Научно-исследовательский институт тесктильных материалов" (ОАО "НИИТМ") Биодеградируемое гемостатическое лекарственное средство
US10765774B2 (en) 2013-07-09 2020-09-08 Ethicon, Inc. Hemostatic pad assembly kit and method
KR101588633B1 (ko) 2013-12-26 2016-01-26 주식회사 삼양바이오팜 지혈 또는 유착방지용 겔 형성용 조성물 및 키트
US10183132B2 (en) * 2014-09-11 2019-01-22 Ethicon Llc Methods and devices for co-delivery of liquid and powdered hemostats and sealants
US9782549B2 (en) * 2014-10-22 2017-10-10 Ethicon, Inc. Distance indicators for medicinal spray devices
US20160193381A1 (en) * 2015-01-06 2016-07-07 St. Teresa Medical, Inc. Hemostatic products
CN104721878B (zh) 2015-04-07 2018-04-06 广州市电纺生物科技有限公司 一种止血材料的制备方法
US10034957B2 (en) 2015-11-06 2018-07-31 Ethicon Llc Compacted hemostatic cellulosic aggregates
CN105536039A (zh) 2015-12-25 2016-05-04 北京大清生物技术有限公司 一种可吸收流体止血材料及其制备方法与应用
CN105617453A (zh) 2016-01-08 2016-06-01 广州市众为生物技术有限公司 一种外科止血生物制品及其使用方法
CN107754005B (zh) 2016-08-15 2021-06-15 广州倍绣生物技术有限公司 止血组合物及其制造方法

Also Published As

Publication number Publication date
CN107754005A (zh) 2018-03-06
EP3766526A1 (fr) 2021-01-20
RU2019107165A3 (fr) 2020-12-14
EP3496769B1 (fr) 2020-09-23
WO2018033835A1 (fr) 2018-02-22
BR112019003015B1 (pt) 2022-10-11
US20180043054A1 (en) 2018-02-15
BR112019003015A2 (pt) 2019-05-14
CN107754005B (zh) 2021-06-15
IL264613A (en) 2019-02-28
PL3496769T3 (pl) 2021-02-22
CA3033932A1 (fr) 2018-02-22
AU2017311658B2 (en) 2021-09-23
US20240269341A1 (en) 2024-08-15
EP3496769A1 (fr) 2019-06-19
IL264613B (en) 2022-03-01
US11229720B2 (en) 2022-01-25
AU2017311658A1 (en) 2019-02-07
RU2019107165A (ru) 2020-09-15
RU2756891C2 (ru) 2021-10-06
US11998656B2 (en) 2024-06-04
JP2019524348A (ja) 2019-09-05
ES2831854T3 (es) 2021-06-09
JP6968870B2 (ja) 2021-11-17
US20220096708A1 (en) 2022-03-31

Similar Documents

Publication Publication Date Title
MA53939A (fr) Compositions hémostatiques et leurs procédés de fabrication
EP3829604A4 (fr) Compositions de plaquettes cryoconservées et leurs procédés de fabrication
EP3823673A4 (fr) Compositions anti-cd112r et procédés
EP3458531A4 (fr) Compositions de revêtement et leurs procédés de préparation
EP3362467A4 (fr) Compositions immunogènes contre le circovirus porcin de type 3 et procédés de fabrication et d'utilisation associés
EP3352774A4 (fr) Compositions de flavonoïdes et procédés d'utilisation
EP3414321A4 (fr) Compositions améliorant vcn et procédés d'utilisation desdites compositions
EP3503879A4 (fr) Compositions et procédés associés
EP3867936A4 (fr) Éponges nano-graphitiques et leurs procédés de fabrication
EP2996694A4 (fr) Compositions de cénicriviroc et leurs procédés de fabrication et d'utilisation
EP3435956A4 (fr) Compositions photo-stabilisées et leurs procédés d'utilisation
IL269334A (en) Improved t cell compositions and methods
EP3341017A4 (fr) Compositions d'immunomodulation et leurs procédés d'utilisation
PT3277270T (pt) Composições e métodos de tratamento de anemia
EP3393655A4 (fr) Compositions de fenfluramine et procédés de préparation de celles-ci
EP3370962A4 (fr) Compositions et procédés de fabrication additive
EP3364986A4 (fr) Compositions de plasma et leurs procédés d'utilisation
EP3310347A4 (fr) Facteurs de coagulation à action prolongée et leurs procédés de production
EP3538628A4 (fr) Compositions oligomères synthétiques et leurs procédés de fabrication
MA45982A (fr) Compositions de neurostéroïdes et leurs procédés d'utilisation
DK3288379T3 (da) Peptidsammensætninger og anvendelsesmåder
EP3393292A4 (fr) Articles de fixation et leurs procédés de fabrication
MA46586A (fr) Compositions de terlipressine et leurs procédés d'utilisation
EP3504546A4 (fr) Compositions de marqueurs et leurs procédés de fabrication et d'utilisation
EP3370737A4 (fr) Compositions anti-vieillissement et leurs procédés d'utilisation