MA54901A - Inhibiteur de 15-pgdh - Google Patents

Inhibiteur de 15-pgdh

Info

Publication number
MA54901A
MA54901A MA054901A MA54901A MA54901A MA 54901 A MA54901 A MA 54901A MA 054901 A MA054901 A MA 054901A MA 54901 A MA54901 A MA 54901A MA 54901 A MA54901 A MA 54901A
Authority
MA
Morocco
Prior art keywords
pgdh inhibitor
pgdh
inhibitor
Prior art date
Application number
MA054901A
Other languages
English (en)
Inventor
Haruaki Kurasaki
Yoshifumi Saito
Shigeki Seto
Hitomi Yamada
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of MA54901A publication Critical patent/MA54901A/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7604067B2 (ja) * 2020-11-26 2024-12-23 エルジー・ケム・リミテッド ジアシルグリセロールキナーゼ阻害剤としての複素環化合物及びその用途
JP2023552832A (ja) * 2020-12-09 2023-12-19 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 関節の構造および機能を改善するためのプロスタグランジン分解酵素１５－ｐｇｄｈの阻害法
GB202106871D0 (en) * 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds
AU2022319753A1 (en) * 2021-07-28 2024-02-22 Epirium Bio Inc. Pyrrolo[2,3-b]pyridine pgdh inhibitors and methods of making and using
CN116120285A (zh) * 2021-11-08 2023-05-16 武汉人福创新药物研发中心有限公司 杂环类化合物及其制备方法和用途
TWI926139B (zh) * 2021-11-18 2026-05-21 大陸商武漢人福創新藥物研發中心有限公司 15-pgdh抑制劑及用途
CA3243368A1 (fr) * 2022-01-28 2025-01-16 Scinnohub Pharmaceutical Co., Ltd. Composé pour réguler et contrôler l'activité de 15-pgdh et son procédé de préparation
US20250250283A1 (en) * 2022-04-13 2025-08-07 Scinnohub Pharmaceutical Co., Ltd. Compound capable of regulating and controlling activity of 15-pgdh, and preparation method therefor
CA3260935A1 (fr) * 2022-07-22 2025-03-31 Scinnohub Pharmaceutical Co., Ltd Composé pour réguler et contrôler l’activité de l’15-pgdh et son procédé de préparation
WO2024067463A1 (fr) * 2022-09-27 2024-04-04 苏州阿尔脉生物科技有限公司 Dérivé de benzo[7]annulène, composition pharmaceutique le comprenant, et utilisations médicales associées
WO2024099429A1 (fr) * 2022-11-11 2024-05-16 赛诺哈勃药业（成都）有限公司 Composé pour réguler et contrôler l'activité de 15-pgdh et son procédé de préparation
JP2026503081A (ja) * 2023-01-20 2026-01-27 イノボ テラピュティクス インク 新規な複素環化合物
CN118908977A (zh) * 2023-05-08 2024-11-08 武汉人福创新药物研发中心有限公司 杂环化合物的晶型、其盐、其盐的晶型及应用
TW202446380A (zh) * 2023-05-19 2024-12-01 大陸商成都倍特藥業股份有限公司 一種調控15-pgdh活性的化合物、包含其的藥物組合物及它們的用途
WO2024254599A1 (fr) * 2023-06-09 2024-12-12 Nimbus Discovery, Inc. Inhibiteurs de hpgd et leurs utilisations
WO2024254601A1 (fr) * 2023-06-09 2024-12-12 Nimbus Discovery, Inc. Inhibiteurs de hpgd et leurs utilisations
WO2026006830A1 (fr) * 2024-06-28 2026-01-02 Case Western Reserve University Compositions et méthodes de traitement de maladies et de troubles caractérisés par une détérioration de la barrière hémato-encéphalique ou la génération d'espèces réactives de l'oxygène
US20260125398A1 (en) * 2024-11-04 2026-05-07 Amgen Inc. 5,6-fused bicyclic alcohol compounds as 15-prostaglandin dehydrogenase modulators
CN121987634A (zh) * 2024-11-07 2026-05-08 湖北生物医药产业技术研究院有限公司 含杂环化合物或其与药学上可接受盐形成的复合物的制剂及其制备方法和应用

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033866A1 (fr) 1996-03-11 1997-09-18 Ube Industries, Ltd. COMPOSES DE β-ANILINOETHANETHIOL, LEUR PROCEDE DE PREPARATION ET PROCEDE DE PREPARATION DE COMPOSES 3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE A PARTIR DE CEUX-CI
US6245760B1 (en) 1997-05-28 2001-06-12 Aventis Pharmaceuticals Products, Inc Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6303627B1 (en) 1998-06-19 2001-10-16 Eli Lilly And Company Inhibitors of serotonin reuptake
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
AU7360700A (en) * 1999-09-09 2001-04-10 Androsolutions, Inc. Methods and compositions for preventing and treating urinary tract disorders
DE60124730T2 (de) 2000-03-03 2007-10-04 Eisai R&D Management Co., Ltd. Neue methoden unter verwendung von cholinesteraseinhibitoren
SI1397364T1 (sl) 2001-05-24 2007-12-31 Lilly Co Eli Novi pirolni derivati kot farmacevtske uäśinkovine
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
AU2002340282B2 (en) 2001-10-23 2007-08-09 Merck Serono Sa Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors
US7320967B2 (en) 2002-04-23 2008-01-22 L'oreal Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair
EP1358868A3 (fr) 2002-04-23 2003-11-19 L'oreal Composition cosmétique pour favoriser la pousse et/ou empecher ou retarder la chute des cheveux
WO2004034963A2 (fr) 2002-05-17 2004-04-29 Eisai Co., Ltd. Methodes et compositions utilisant des inhibiteurs de la cholinesterase
EP1594438B1 (fr) 2003-02-12 2013-07-17 L'Oréal Utilisation d'un inhibiteur de 15-hydroxy prostaglandine déshydrogénase pour favoriser la pigmentation de la peau ou des phanères
WO2004089416A2 (fr) 2003-04-11 2004-10-21 Novo Nordisk A/S Polytherapie utilisant un inhibiteur de type 1 de la 11beta-hydroxysteroide deshydrogenase et un agent hypotenseur dans le traitement du syndrome metabolique et des troubles et maladies associes
GB0320320D0 (en) 2003-08-29 2003-10-01 Glaxo Group Ltd Novel compounds
FR2869224B1 (fr) 2004-04-22 2006-06-09 Oreal Compose 2-oxy-acetamide, ses utilisations et compositions pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute
AR051780A1 (es) 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP1851203A2 (fr) 2005-02-08 2007-11-07 Merck & Co., Inc. Inhibiteurs de kinases de controle
US20090111805A1 (en) 2005-02-24 2009-04-30 Pfizer Inc. Bicyclic heteroaromatic derivatives useful as anticancer agents
EP1896461A2 (fr) 2005-06-30 2008-03-12 Amgen Inc. Inhibiteurs de bis-aryl kinase et leur utilisation pour le traitement de l'inflammation, de l'angiogenese et du cancer
FR2891457B1 (fr) 2005-10-05 2007-11-23 Oreal Utilisation de composes phenyl-furyl-methyl-thiazolidine-2,4 dione ou phenyl-thienyl-methyl-thiazolidine-2,4-diones pour favoriser et/ou induire et/ou stimuler la pigmentation des matieres keratiniques et/ou limiter leur depigmentation et/
US20070077215A1 (en) 2005-10-05 2007-04-05 L'oreal Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening
AU2007214594B2 (en) 2006-02-13 2010-11-11 F. Hoffmann-La Roche Ag Heterobicyclic sulfonamide derivatives for the treatment of diabetes
US20080305169A1 (en) 2006-05-26 2008-12-11 Japan Tobacco Inc. Pharmaceutical Compositions Comprising Nitrogen-Containing Fused Ring Coumpounds
US20080064871A1 (en) 2006-05-26 2008-03-13 Japan Tobacco Inc. Production Method of Nitrogen-Containing Fused Ring Compounds
GB0611759D0 (en) 2006-06-14 2006-07-26 Victrex Mfg Ltd Polymeric material
WO2008001076A1 (fr) 2006-06-26 2008-01-03 Ucb Pharma S.A. Dérivés de thiazole à cycle fusionnés en tant qu'inhibiteurs de kinase
EA019103B1 (ru) 2007-03-20 2014-01-30 Кьюрис, Инк. Конденсированный аминопиридин в качестве ингибиторов hsp90
WO2009017838A2 (fr) 2007-08-01 2009-02-05 Exelixis, Inc. Combinaisons d'inhibiteurs jak-2 et d'autres agents
US7960376B2 (en) 2007-09-14 2011-06-14 Cara Therapeutics, Inc. Benzo-fused heterocycles
KR101536021B1 (ko) 2007-10-16 2015-07-10 다이이찌 산쿄 가부시키가이샤 피리미딜 인돌린 화합물
CN101939288A (zh) 2008-02-05 2011-01-05 阿斯特兰德英国有限公司 用于治疗高眼压的二氟联苯酰胺衍生物
TWI386204B (zh) 2008-04-10 2013-02-21 Mitsubishi Tanabe Pharma Corp 高半胱胺酸合成酶抑制劑
EP2341052A4 (fr) 2008-09-05 2011-10-12 Shionogi & Co Derive de morpholine à cycles condensés ayant une activite inhibitrice de pi3k
EP2210891A1 (fr) 2009-01-26 2010-07-28 Domain Therapeutics Nouveaux ligands du récepteur de l'adénosine et leurs utilisations
RU2558141C2 (ru) * 2009-04-22 2015-07-27 Янссен Фармацевтика Нв Гетероароматические и ароматические пиперазинилазетидиниламиды в качестве ингибиторов моноацилглицеринлипазы
EP2322176A1 (fr) 2009-11-11 2011-05-18 Almirall, S.A. Nouveaux dérivés de 7-phényl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
BR112013010958A8 (pt) * 2010-10-22 2017-10-03 Api Genesis Llc Métodos para elevar a solubilidade de compostos pouco solúveis e métodos para fabricação e para uso de formulações de tais compostos
WO2012094462A2 (fr) * 2011-01-05 2012-07-12 Bioenergenix Composés hétérocycliques pour l'inhibition de la pask
USRE47009E1 (en) 2011-02-01 2018-08-28 The Children's Hospital Of Philadelphia HDAC inhibitors and therapeutic methods using the same
JP2014518267A (ja) 2011-06-27 2014-07-28 杏林製薬株式会社 細菌感染症の治療のための架橋二環式化合物
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
WO2016144958A1 (fr) 2015-03-08 2016-09-15 Case Western Reserve University Inhibiteurs de l'activité de la déshydrogénase à chaîne courte pour le traitement de la fibrose
CA2870666A1 (fr) 2012-04-16 2013-10-24 Case Western Reserve University Compositions et methodes pour moduler l'activite 15-pgdh
EA029892B1 (ru) 2012-04-25 2018-05-31 Такеда Фармасьютикал Компани Лимитед Азотсодержащее гетероциклическое соединение
KR20150022789A (ko) 2012-06-04 2015-03-04 키에시 파르마슈티시 엣스. 피. 에이. 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체
FR2992316A1 (fr) 2012-06-22 2013-12-27 Sanofi Sa Derives de pyrimidinones, leur preparation et leur application en therapeutique
CA2927730A1 (fr) * 2013-10-15 2015-05-07 Case Western Reserve University Compositions et procedes de modulation de l'activite de la deshydrogenase a chaine courte
WO2015115673A1 (fr) 2014-01-31 2015-08-06 Ono Pharmaceutical Co., Ltd. Composés d'imidazole condensés
KR101551313B1 (ko) 2014-07-28 2015-09-09 충남대학교산학협력단 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물
CA2971413A1 (fr) 2014-12-16 2016-06-23 Axovant Sciences Gmbh Composes amide de quinuclidine a substituants geminal, en tant qu'agonistes des recepteurs nicotiniques de l'acetylcholine ?7
HK1247813A1 (zh) 2015-02-24 2018-10-05 Pitney Pharmaceuticals Pty Limited 一种含有氨基乙腈化合物作为活性成分的抗癌剂
KR101663277B1 (ko) 2015-03-30 2016-10-06 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물
EP3283074A4 (fr) 2015-04-14 2018-12-05 Case Western Reserve University Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
EP3372601B1 (fr) 2015-10-22 2022-09-21 Mitsubishi Tanabe Pharma Corporation Nouveau composé hétérocyclique bicyclique
SG11201803242TA (en) 2015-10-29 2018-05-30 Effector Therapeutics Inc Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2
WO2017147328A1 (fr) 2016-02-23 2017-08-31 Portola Pharmaceuticals, Inc. Composés se liant à la proprotéine convertase subtilisine/kexine de type 9 (pcsk9)
CA3031091A1 (fr) 2016-07-18 2018-01-25 Case Western Reserve University Inhibiteurs de l'activite deshydrogenase a chaine courte pour favoriser la neurogenese et inhiber la mort des cellules nerveuses
EP3548035A4 (fr) * 2016-11-30 2020-07-22 Case Western Reserve University Combinaisons d'inhibiteurs de 15-pgdh avec des corcostéroïdes et/ou des inhibiteurs du tnf et leurs utilisations
CN110573154A (zh) 2017-02-06 2019-12-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
US12138263B2 (en) 2018-03-21 2024-11-12 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof
JP7677983B2 (ja) 2020-01-23 2025-05-15 マイオフォルテ セラピューティクス，インク． Ｐｇｄｈ阻害剤、およびその作製と使用の方法

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IL283608A (en) 2021-07-29
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AU2020207089A1 (en) 2021-06-24
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