MA55206A - Polyribonucléotides circulaires et compositions pharmaceutiques associées - Google Patents

Polyribonucléotides circulaires et compositions pharmaceutiques associées

Info

Publication number
MA55206A
MA55206A MA055206A MA55206A MA55206A MA 55206 A MA55206 A MA 55206A MA 055206 A MA055206 A MA 055206A MA 55206 A MA55206 A MA 55206A MA 55206 A MA55206 A MA 55206A
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
related pharmaceutical
circular polyribonucleotides
polyribonucleotides
circular
Prior art date
Application number
MA055206A
Other languages
English (en)
Inventor
Catherine Cifuentes-Rojas
Boer Alexandra Sophie De
Avak Kahvejian
Michael Donato Melfi
Ki Young Paek
Nicholas Mccartney Plugis
Original Assignee
Flagship Pioneering Innovations Vi Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations Vi Llc filed Critical Flagship Pioneering Innovations Vi Llc
Publication of MA55206A publication Critical patent/MA55206A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA055206A 2019-03-04 2020-03-04 Polyribonucléotides circulaires et compositions pharmaceutiques associées MA55206A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962813666P 2019-03-04 2019-03-04
US201962825683P 2019-03-28 2019-03-28
US201962840174P 2019-04-29 2019-04-29
US202062967545P 2020-01-29 2020-01-29

Publications (1)

Publication Number Publication Date
MA55206A true MA55206A (fr) 2022-01-12

Family

ID=70110338

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055206A MA55206A (fr) 2019-03-04 2020-03-04 Polyribonucléotides circulaires et compositions pharmaceutiques associées

Country Status (10)

Country Link
US (1) US20220143062A1 (fr)
EP (1) EP3935162A1 (fr)
JP (2) JP2022523794A (fr)
KR (1) KR20210135265A (fr)
CN (3) CN121081490A (fr)
AU (1) AU2020233404A1 (fr)
CA (1) CA3128626A1 (fr)
IL (1) IL285906A (fr)
MA (1) MA55206A (fr)
WO (1) WO2020181013A1 (fr)

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BR112020011670A2 (pt) 2017-12-15 2020-11-17 Flagship Pioneering Innovations Vi, Llc. composições compreendendo polirribonucleotídeos circulares e seus usos
CA3131319A1 (fr) 2019-03-25 2020-10-01 Avak Kahvejian Compositions comprenant des polyribonucleotides circulaires modifies et utilisations associees
JP2023553010A (ja) 2020-12-03 2023-12-20 バテル・メモリアル・インスティテュート 非ウイルス性送達のためのポリマーナノ粒子およびｄｎａナノ構造組成物ならびに方法
EP4291229A4 (fr) * 2021-02-09 2025-03-26 Virginia Commonwealth University Thérapies et vaccins à base de mini-arn circulaire et leurs procédés d'utilisation
WO2022204464A1 (fr) * 2021-03-26 2022-09-29 Flagship Pioneering Innovations Vii, Llc Production de polyribonucléotides circulaires dans un système eucaryote
EP4314289A1 (fr) * 2021-03-26 2024-02-07 Flagship Pioneering Innovations VII, LLC Production de polyribonucléotides circulaires dans un système procaryote
EP4314277A1 (fr) * 2021-03-26 2024-02-07 Flagship Pioneering Innovations VII, LLC Compositions et procédés de production de polyribonucléotides circulaires
EP4320233A4 (fr) 2021-04-07 2025-08-13 Battelle Memorial Institute Technologies de conception, de construction, de test et d'apprentissage rapides pour identifier et utiliser des vecteurs non viraux
JP2024523054A (ja) * 2021-05-18 2024-06-26 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 環状ポリリボヌクレオチドを濃縮する方法
EP4341424A1 (fr) * 2021-05-18 2024-03-27 Flagship Pioneering Innovations VI, LLC Procédés d'enrichissement de polyribonucléotides circulaires
JP2024528875A (ja) 2021-07-27 2024-08-01 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 処理のための装置、システム及び方法
AR127073A1 (es) * 2021-09-17 2023-12-13 Flagship Pioneering Innovations Vi Llc Composiciones y métodos para producir polirribonucleótidos circulares
US20250027108A1 (en) * 2021-10-29 2025-01-23 CureVac SE Improved circular rna for expressing therapeutic proteins
KR102488280B1 (ko) * 2021-11-25 2023-01-16 주식회사 뉴클릭스바이오 신규한 부목 dna 및 이의 용도
CN114317684B (zh) * 2021-12-15 2023-12-26 南京大学 一种基于tna分子的细胞内镁离子成像的方法
AU2022413687A1 (en) 2021-12-17 2024-06-27 Flagship Pioneering Innovations Vi, Llc Methods for enrichment of circular rna under denaturing conditions
US20250108134A1 (en) * 2022-01-28 2025-04-03 Beijing Changping Laboratory Circular rna vaccines and methods of use thereof
WO2024097664A1 (fr) * 2022-10-31 2024-05-10 Flagship Pioneering Innovations Vi, Llc Compositions et procédés de purification de polyribonucléotides
EP4648794A2 (fr) 2023-01-09 2025-11-19 Flagship Pioneering Innovations VII, LLC Vaccins et procédés associés
WO2024159172A1 (fr) 2023-01-27 2024-08-02 Senda Biosciences, Inc. Composition lipidique modifiée et ses utilisations
TW202438515A (zh) 2023-02-06 2024-10-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 免疫調節組合物及相關方法
CN116286916B (zh) * 2023-02-24 2025-08-22 北京大学人民医院 一种改良的i型内含子核酶序列用于构建环状rna的方法及应用
TW202517783A (zh) * 2023-06-28 2025-05-01 香港商瑞毅生物科技（香港）有限公司 工程化的rna多核苷酸及其製備方法
WO2025072751A1 (fr) 2023-09-29 2025-04-03 Battelle Memorial Institute Compositions de nanoparticules polymères pour l'expression in vivo de polypeptides
WO2025087301A1 (fr) * 2023-10-24 2025-05-01 Therorna Shanghai Co., Ltd. Arn circulaire codant pour glp-1 et son utilisation
WO2025106915A1 (fr) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Polyribonucléotides circulaires codant le peptide 1 de type glucagon (glp-1) et leurs utilisations
WO2025106930A1 (fr) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Polyribonucléotides circulaires codant le peptide 2 de type glucagon (glp-2) et leurs utilisations
WO2025122954A1 (fr) 2023-12-08 2025-06-12 Battelle Memorial Institute Utilisation de nanostructures d'origami d'adn pour systèmes de stockage de données basés sur des informations moléculaires
WO2025160334A1 (fr) 2024-01-26 2025-07-31 Flagship Pioneering Innovations Vii, Llc Protéines inhibitrices d'immunorécepteurs et procédés associés
WO2025179198A1 (fr) 2024-02-23 2025-08-28 Sail Biomedicines, Inc. Polyribonucléotides circulaires et arn linéaires non modifiés à immunogénicité réduite
WO2025227064A1 (fr) * 2024-04-26 2025-10-30 Renasci Biotechnologies, Inc. Méthodes d'édition génomique pour le traitement d'une maladie cardiovasculaire et compositions destinées à être utilisées dans la mise en œuvre de celles-ci
WO2025240369A2 (fr) * 2024-05-13 2025-11-20 Helix Nanotechnologies Inc Procédés de distribution de polyribonucléotides nus
WO2025240680A1 (fr) 2024-05-16 2025-11-20 Flagship Pioneering Innovations Vii, Llc Protéines inhibitrices d'immunorécepteurs et procédés associés
WO2025245111A1 (fr) 2024-05-22 2025-11-27 Flagship Pioneering Innovations Vii, Llc Protéines de ciblage d'immunorécepteurs et procédés associés
CN118581085A (zh) * 2024-05-24 2024-09-03 国家纳米科学中心 一种翻译调控元件、表达载体、药物组合物、疫苗组合物、构建方法、表达目的蛋白的方法及应用
CN118688370B (zh) * 2024-08-27 2024-12-13 天津辰欣药物研究有限公司 一种抗病毒新药中间体的质量控制方法

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US5773244A (en) 1993-05-19 1998-06-30 Regents Of The University Of California Methods of making circular RNA
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US6429301B1 (en) 1998-04-17 2002-08-06 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
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BR112020011670A2 (pt) * 2017-12-15 2020-11-17 Flagship Pioneering Innovations Vi, Llc. composições compreendendo polirribonucleotídeos circulares e seus usos
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Also Published As

Publication number Publication date
CN113544269A (zh) 2021-10-22
CN121081490A (zh) 2025-12-09
JP2025090772A (ja) 2025-06-17
JP2022523794A (ja) 2022-04-26
CN121081491A (zh) 2025-12-09
WO2020181013A1 (fr) 2020-09-10
US20220143062A1 (en) 2022-05-12
AU2020233404A1 (en) 2021-09-16
IL285906A (en) 2021-10-31
CA3128626A1 (fr) 2020-09-10
KR20210135265A (ko) 2021-11-12
EP3935162A1 (fr) 2022-01-12

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