MA55380A - Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace - Google Patents

Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace

Info

Publication number
MA55380A
MA55380A MA055380A MA55380A MA55380A MA 55380 A MA55380 A MA 55380A MA 055380 A MA055380 A MA 055380A MA 55380 A MA55380 A MA 55380A MA 55380 A MA55380 A MA 55380A
Authority
MA
Morocco
Prior art keywords
production
pharmaceutical composition
effective constituent
heteroaryl derivative
heteroaryl
Prior art date
Application number
MA055380A
Other languages
English (en)
Inventor
Hwan Geun Choi
Ah Reum Han
Dong Keun Hwang
Ju Hee Kang
Se In Kang
Da Eun Kim
Hwan Kim
Nam Doo Kim
Seung Su Kim
Eun Hwa Ko
Yi Kyung Ko
Sun Hwa Lee
Youn Ho Lee
Min Seok Ryu
Ji Yoon Seok
Jung Beom Son
Original Assignee
B2Sbio Inc
Voronoi Inc
Voronoibio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B2Sbio Inc, Voronoi Inc, Voronoibio Inc filed Critical B2Sbio Inc
Publication of MA55380A publication Critical patent/MA55380A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA055380A 2019-03-19 2020-03-19 Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace MA55380A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190031269 2019-03-19
KR20190134472 2019-10-28

Publications (1)

Publication Number Publication Date
MA55380A true MA55380A (fr) 2022-01-26

Family

ID=72521153

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055380A MA55380A (fr) 2019-03-19 2020-03-19 Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace

Country Status (22)

Country Link
US (2) US12152021B2 (fr)
EP (2) EP4631507A3 (fr)
JP (2) JP7109013B2 (fr)
KR (2) KR102318875B1 (fr)
CN (3) CN113993866B (fr)
AU (2) AU2020240382B2 (fr)
BR (1) BR112021018704B1 (fr)
CA (1) CA3134261A1 (fr)
DK (1) DK3943491T3 (fr)
ES (1) ES3036467T3 (fr)
FI (1) FI3943491T3 (fr)
HU (1) HUE073283T2 (fr)
IL (2) IL299831B2 (fr)
MA (1) MA55380A (fr)
MX (1) MX2021011160A (fr)
NZ (2) NZ781366A (fr)
PL (1) PL3943491T3 (fr)
PT (1) PT3943491T (fr)
SG (1) SG11202110376XA (fr)
SI (1) SI3943491T1 (fr)
WO (1) WO2020190119A1 (fr)
ZA (1) ZA202107889B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020240382B2 (en) 2019-03-19 2022-08-25 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
US12157730B2 (en) 2019-03-19 2024-12-03 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
TW202227425A (zh) * 2020-09-18 2022-07-16 南韓商沃若諾伊生物公司 雜芳基衍生物、彼之製法、及包含彼作為活性成份之藥學組成物
KR20220085735A (ko) * 2020-12-14 2022-06-22 보로노이바이오 주식회사 아이소옥사졸리딘 유도체 화합물 및 이의 용도
CA3213079A1 (fr) 2021-04-13 2022-10-20 Kristin Lynne ANDREWS Heterocycles amino-substitues pour le traitement de cancers avec des mutations egfr
JP2024516721A (ja) * 2021-05-07 2024-04-16 ボロノイ インコーポレイテッド ヘテロアリール誘導体、これを製造する方法、およびこれを有効成分として含む薬学的組成物
AU2022271388A1 (en) * 2021-05-17 2022-12-01 Voronoi Inc. Heteroaryl derivative compounds, and uses thereof
KR102563834B1 (ko) * 2021-06-28 2023-08-04 순천대학교 산학협력단 세포자멸사를 유도하는 신규한 화합물 및 이를 포함하는 항암용 조성물
CN117430600A (zh) * 2022-07-20 2024-01-23 上海和誉生物医药科技有限公司 一种选择性egfr抑制剂及其制备方法和在药学上的应用
JP7852427B2 (ja) 2022-08-05 2026-04-28 三菱マテリアル株式会社 切削工具
EP4612147A1 (fr) * 2022-11-03 2025-09-10 Voronoi Inc. Sels de fumarate, tartrate, malate et de citrate d'un inhibiteur d'egfr
WO2024097848A1 (fr) * 2022-11-03 2024-05-10 Oric Pharmaceuticals, Inc. Sels de malonate et de glycolate d'un inhibiteur d'egfr
WO2024106914A1 (fr) * 2022-11-15 2024-05-23 Voronoi Inc. Composé dérivé hétéroaryle et ses utilisations
MX2025012495A (es) 2023-05-05 2026-02-03 Oric Pharmaceuticals Inc Inhibidor del receptor del factor de crecimiento epidérmico (egfr) para tratamiento de cánceres con mutaciones atípicas del factor de crecimiento epidérmico
WO2026080372A1 (fr) 2024-10-07 2026-04-16 Oric Pharmaceuticals, Inc. Traitement de cancers comprenant des mutations extracellulaires et transmembranaires d'egfr

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1415987B1 (fr) 2000-10-20 2007-02-28 Eisai R&D Management Co., Ltd. Composes heteroaromatiques azotes pour le traitement des maladies de cancer
EP1678147B1 (fr) 2003-09-15 2012-08-08 Lead Discovery Center GmbH Derives d'aminopyrimidine a disubstitution 4,6 actifs sur le plan pharmaceutique en tant que modulateurs des proteine kinases
JP2008542219A (ja) 2005-05-25 2008-11-27 インゲニウム ファーマシューティカルズ ジーエムビーエイチ 疼痛処置法
TW200804364A (en) 2006-02-22 2008-01-16 Boehringer Ingelheim Int New compounds
CN101686675A (zh) 2007-03-20 2010-03-31 史密丝克莱恩比彻姆公司 化合物
TWI377944B (en) 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
JP2011102241A (ja) 2008-03-04 2011-05-26 Dainippon Sumitomo Pharma Co Ltd 新規１−アミノカルボニルピペリジン誘導体
NZ598262A (en) 2009-08-17 2014-05-30 Sloan Kettering Inst Cancer Heat shock protein binding compounds, compositions, and methods for making and using same
KR101401664B1 (ko) 2011-11-15 2014-06-11 중앙대학교 산학협력단 신경줄기세포 분화조절제용 신규 피리미딘-2,4-디아민 유도체 및 이의 의학적 용도
CA2863517C (fr) 2012-01-20 2019-11-05 Genosco Composes de type pyrimidine substituee et leur utilisation en tant qu'inhibiteurs des kinases syk
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
CA2887435A1 (fr) 2012-10-04 2014-04-10 University Of Utah Research Foundation Analogues de n-(3-(pyrimidin-4-yl)phenyl) substitue utilises en tant qu'inhibiteurs de recepteur tyrosine kinase btk
EP2769722A1 (fr) 2013-02-22 2014-08-27 Ruprecht-Karls-Universität Heidelberg Composés utilisés pour inhiber un assemblage de capside du VIH
KR20150131224A (ko) 2013-03-14 2015-11-24 노파르티스 아게 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온
BR112016003247B1 (pt) 2013-08-22 2022-05-10 Taiho Pharmaceutical Co., Ltd Composto substituído por quinolina, composição farmacêutica compreendendo o referido composto e seu uso
KR20160063366A (ko) 2013-10-21 2016-06-03 메르크 파텐트 게엠베하 Btk 저해제로서 헤테로아릴 화합물 및 이들의 용도
KR20150047855A (ko) 2013-10-25 2015-05-06 한미약품 주식회사 단백질 카이네이즈 억제 효과를 갖는 2-사이아노-아크릴아마이드 유도체
JP6468611B2 (ja) 2014-05-13 2019-02-13 アリアド ファーマシューティカルズ， インコーポレイテッド キナーゼ阻害のためのヘテロアリール化合物
MY186839A (en) 2014-06-19 2021-08-25 Takeda Pharmaceuticals Co Heteroaryl compounds for kinase inhibition
PL3205650T3 (pl) 2014-10-11 2021-12-06 Shanghai Hansoh Biomedical Co., Ltd. Inhibitor EGFR i jego otrzymywanie i zastosowanie
NZ730012A (en) * 2014-10-13 2019-06-28 Yuhan Corp Compounds and compositions for modulating egfr mutant kinase activities
EP3206691B1 (fr) 2014-10-14 2018-09-19 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryle substitués et leurs méthodes d'utilisation
US10266517B2 (en) 2014-12-23 2019-04-23 Dana-Farber Cancer Institute, Inc. Pyrimidines as EGFR inhibitors and methods of treating disorders
CA2992317A1 (fr) 2015-07-16 2017-01-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Derives d'aniline pyrimidine et leurs utilisations
CN106478607B (zh) * 2015-08-28 2019-05-24 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
CN106132957B (zh) 2015-08-31 2018-06-12 无锡双良生物科技有限公司 2-芳胺基吡啶、嘧啶或三嗪衍生物及其制备方法和用途
CN108602809B (zh) 2015-12-04 2022-09-30 戴纳立制药公司 异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂
TWI726968B (zh) 2016-01-07 2021-05-11 開曼群島商Ｃｓ醫藥技術公司 Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑
WO2017156527A1 (fr) 2016-03-11 2017-09-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibiteurs des kinases aurora et des janus kinases pour la prévention de la maladie du greffon contre l'hôte
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
CN108707139B (zh) 2017-06-13 2021-04-06 北京鞍石生物科技有限责任公司 氨基嘧啶类化合物及其制备方法和应用
KR20200028966A (ko) 2017-07-05 2020-03-17 씨에스 파마테크 리미티드 Efgr 티로신 키나제의 임상적으로 중요한 돌연변이체의 선택적 억제제
CA3079786A1 (fr) 2017-10-24 2019-05-02 The Broad Institute, Inc. Derives de 4h-pyrrolo[3,2-c]pyridin-4-one
CN108191774B (zh) 2018-01-31 2022-05-24 中国药科大学 一类杂环化合物、其制备方法和用途
TWI798334B (zh) 2018-01-31 2023-04-11 大陸商迪哲（江蘇）醫藥股份有限公司 Ｅｒｂｂ／ｂｔｋ抑制劑
WO2019177375A1 (fr) 2018-03-13 2019-09-19 포로노이바이오 주식회사 Dérivés de pyrimidine substitués en positions 2, 4 et 5, leur procédé de préparation et composition pharmaceutique pour la prévention ou le traitement du cancer les contenant en tant que principe actif
KR102901976B1 (ko) 2018-03-13 2025-12-24 보로노이 주식회사 2,4,5-치환된 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 또는 염증질환의 예방 또는 치료용 약학적 조성물
EP4234547A3 (fr) 2018-05-14 2023-11-01 Takeda Pharmaceutical Company Limited Sels pharmaceutiques de dérivés de pyrimidine et méthode de traitement d'affections
CN109280048A (zh) 2018-11-16 2019-01-29 江西科技师范大学 一种含取代苯基丙烯酰胺结构的嘧啶类化合物及其应用
CN109608394A (zh) 2018-12-03 2019-04-12 湖南大学 氮杂芳胺类化合物的合成方法和氮杂芳胺类化合物
US12157730B2 (en) 2019-03-19 2024-12-03 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
AU2020240382B2 (en) * 2019-03-19 2022-08-25 Voronoi Inc. Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component

Also Published As

Publication number Publication date
EP4631507A2 (fr) 2025-10-15
US20220073505A1 (en) 2022-03-10
ES3036467T3 (en) 2025-09-19
EP3943491B1 (fr) 2025-06-18
SI3943491T1 (sl) 2025-08-29
BR112021018704A2 (fr) 2021-11-23
AU2022211789A1 (en) 2022-08-25
MX2021011160A (es) 2022-02-10
AU2020240382A1 (en) 2021-11-11
US11466000B2 (en) 2022-10-11
DK3943491T3 (da) 2025-07-14
KR20210130123A (ko) 2021-10-29
IL299831B1 (en) 2025-08-01
NZ790920A (en) 2026-02-27
HUE073283T2 (hu) 2026-01-28
CN114605400A (zh) 2022-06-10
CA3134261A1 (fr) 2020-09-24
IL286471B1 (en) 2023-04-01
AU2020240382B2 (en) 2022-08-25
CN115838369A (zh) 2023-03-24
PL3943491T3 (pl) 2025-11-17
CN113993866A (zh) 2022-01-28
CN113993866B (zh) 2022-10-28
PT3943491T (pt) 2025-07-28
BR112021018704B1 (pt) 2023-01-10
US12152021B2 (en) 2024-11-26
CN114605400B (zh) 2024-09-10
EP3943491A1 (fr) 2022-01-26
EP4631507A3 (fr) 2025-12-24
KR102318875B1 (ko) 2021-11-01
NZ781366A (en) 2022-08-26
SG11202110376XA (en) 2021-10-28
JP2022522250A (ja) 2022-04-14
IL286471A (en) 2021-12-01
AU2022211789B2 (en) 2024-06-27
IL299831A (en) 2023-03-01
JP2022125283A (ja) 2022-08-26
JP7394298B2 (ja) 2023-12-08
FI3943491T3 (fi) 2025-07-31
IL286471B2 (en) 2023-08-01
JP7109013B2 (ja) 2022-07-29
US20220162203A1 (en) 2022-05-26
WO2020190119A1 (fr) 2020-09-24
ZA202107889B (en) 2024-02-28
KR102564533B1 (ko) 2023-08-08
IL299831B2 (en) 2025-12-01
KR20200111644A (ko) 2020-09-29
EP3943491A4 (fr) 2022-11-23

Similar Documents

Publication Publication Date Title
EP3943491A4 (fr) Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace
EP3750887A4 (fr) Dérivé de biaryle, son procédé de préparation, et son application pharmaceutique
EP3978496A4 (fr) Dérivé de cycle inhibiteur de btk, son procédé de préparation et son application pharmaceutique
EP3450423A4 (fr) Dérivé de benzylphényl éther, son procédé de préparation et composition pharmaceutique et utilisations associées
EP3459940A4 (fr) Dérivé de 5-aminopyrazole carboxamide en tant qu'inhibiteur de la btk, son procédé de préparation et composition pharmaceutique associée
EP3357491A4 (fr) Composition pharmaceutique contenant un médicament anionique, et son procédé de préparation
EP3909982A4 (fr) Anticorps cd73, son procédé de préparation et son application
EP3486242A4 (fr) Dérivé d'oxopicolinamide, son procédé de préparation et son utilisation pharmaceutique
EP3398939A4 (fr) Dérivé d'acrylanilide, son procédé de préparation et ses applications en pharmacie
EP4079734A4 (fr) Dérivé de triazolopyridazine, son procédé de préparation, composition pharmaceutique associée et utilisation correspondante
EP3524603A4 (fr) Inhibiteur de fgfr4, son procédé de préparation et son utilisation pharmaceutique
EP4056571A4 (fr) Dérivé de dihydroimidazopyrimidone tricyclique, son procédé de préparation, composition pharmaceutique et son utilisation
EP3744316A4 (fr) Composition pharmaceutique ophtalmique, son procédé de préparation et son application
EP3404024A4 (fr) Dérivé de quinazolinone, son procédé de préparation, composition pharmaceutique, et applications associées
BR112017019287A2 (pt) composto, composição farmaceuticamente aceitável, método de tratamento de câncer, processo para preparar o composto da fórmula i, método para tratar câncer, e kit
EP4056177A4 (fr) Préparation de nanomicelles de cannabinoïde et son procédé de préparation
EP3805231A4 (fr) Inhibiteur contenant un dérivé tricyclique, son procédé de préparation et son application
EP3352006A4 (fr) Composition d'étanchéité, panneau d'affichage et son procédé de préparation, et appareil d'affichage
EP3498716A4 (fr) Composé thiénopyrimidine, son procédé de préparation, composition pharmaceutique et applications associées
EP3466946A4 (fr) Thiophène, son procédé de fabrication, et application pharmaceutique correspondante
EP3943089A4 (fr) Formulation lyophilisée, procédé de préparation et application correspondante
EP3653202A4 (fr) Préparation pharmaceutique et son procédé de préparation
EP3398615A4 (fr) Composition pharmaceutique mucoadhésive et son procédé de préparation
EP3556769A4 (fr) Dérivé de polyximine, procédé de préparation et application associés
EP3623503A4 (fr) Médicament protéique multispécifique et bibliothèque associée, procédé de préparation associé et application associée