MA55976A - Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide - Google Patents

Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide

Info

Publication number
MA55976A
MA55976A MA055976A MA55976A MA55976A MA 55976 A MA55976 A MA 55976A MA 055976 A MA055976 A MA 055976A MA 55976 A MA55976 A MA 55976A MA 55976 A MA55976 A MA 55976A
Authority
MA
Morocco
Prior art keywords
fluorocyclopropyl
oxadiazol
imidazo
carboxamide
methylphenyl
Prior art date
Application number
MA055976A
Other languages
English (en)
Inventor
Andreas Kordikowski
Xiaoyang Wang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA55976A publication Critical patent/MA55976A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA055976A 2019-05-13 2020-05-13 Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide MA55976A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2019086582 2019-05-13

Publications (1)

Publication Number Publication Date
MA55976A true MA55976A (fr) 2022-03-23

Family

ID=73289607

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055976A MA55976A (fr) 2019-05-13 2020-05-13 Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide

Country Status (14)

Country Link
US (1) US20220194936A1 (fr)
EP (1) EP3969453A4 (fr)
JP (1) JP2022533340A (fr)
KR (1) KR20220007650A (fr)
CN (1) CN114096538A (fr)
AU (1) AU2020274564A1 (fr)
BR (1) BR112021022685A2 (fr)
CA (1) CA3139552A1 (fr)
IL (1) IL287877A (fr)
MA (1) MA55976A (fr)
MX (1) MX2021013814A (fr)
SG (1) SG11202112281UA (fr)
TW (1) TW202108581A (fr)
WO (1) WO2020228746A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11767319B2 (en) * 2020-07-15 2023-09-26 Third Harmonic Bio, Inc. Crystalline forms of a selective c-kit kinase inhibitor
US20220175740A1 (en) * 2020-11-19 2022-06-09 Novartis Ag Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
US11744823B2 (en) * 2020-11-19 2023-09-05 Third Harmonic Bio, Inc. Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
EP4626884A1 (fr) 2022-11-30 2025-10-08 Blueprint Medicines Corporation Dérivés de n-phényl-pyrazolo[1,5-a]pyridine-3-carboxamide utilisés en tant qu'inhibiteurs de kinase c-kit de type sauvage pour le traitement de l'urticaire
WO2025146196A1 (fr) * 2024-01-04 2025-07-10 上海翰森生物医药科技有限公司 Inhibiteur à dérivé polycyclique, son procédé de préparation et son utilisation
WO2025256609A1 (fr) * 2024-06-13 2025-12-18 Third Harmonic Bio, Inc. Formes cristallines d'un inhibiteur sélectif de kinase c-kit

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012302176A1 (en) * 2011-09-01 2014-04-17 Irm Llc Compounds and compositions as c-kit kinase inhibitors
US9199981B2 (en) * 2011-09-01 2015-12-01 Novartis Ag Compounds and compositions as C-kit kinase inhibitors
JP6134319B2 (ja) * 2011-09-01 2017-05-24 ノバルティス アーゲー ｃ−ｋｉｔキナーゼインヒビターとしての化合物及び組成物
US20150051206A1 (en) * 2011-09-01 2015-02-19 Irm Llc Compounds and compositions as c-kit kinase inhibitors

Also Published As

Publication number Publication date
SG11202112281UA (en) 2021-12-30
MX2021013814A (es) 2022-02-10
WO2020228746A1 (fr) 2020-11-19
IL287877A (en) 2022-01-01
JP2022533340A (ja) 2022-07-22
EP3969453A1 (fr) 2022-03-23
BR112021022685A2 (pt) 2022-03-29
US20220194936A1 (en) 2022-06-23
CA3139552A1 (fr) 2020-11-19
CN114096538A (zh) 2022-02-25
KR20220007650A (ko) 2022-01-18
AU2020274564A1 (en) 2021-12-09
EP3969453A4 (fr) 2023-01-18
TW202108581A (zh) 2021-03-01

Similar Documents

Publication Publication Date Title
MA55976A (fr) Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide
DK3464285T3 (da) Fremgangsmåde til fremstilling af n-(5-(3-(7-(3-fluorphenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamid
MA54755A (fr) Dérivés d'imidazo[1,2-a]pyridinyle servant d'inhibiteurs d'irak4
IL281127A (en) Pyrazolo[3,4-b]pyridine compounds as inhibitors of tam and met kinases
DK3800189T3 (da) Fremstilling af (s)-n-(5-((r)-2-(2,5-difluorphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid
DK2361609T3 (da) Formulering af småmolekylære lægemidler med forsinket frigivelse
AR078766A1 (es) Formas solidas de n-(4-(7-azabiciclo(2.2.1) heptan-7-il)-2-( trifluorometil) fenil)-4-oxo-5-(trifluorometil)-1,4- dihidroquinolina-3-carboxamida
EA201990518A1 (ru) Производные пиразолопиридина, обладающие эффектом агониста рецептора glp-1
ATE541845T1 (de) 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen
SMT201300098B (it) Forme solide di N-(4-(7-azabiciclo[2.2.1]eptan-7-il)-2-(trifluorometil)fenil-4-osso-5-trifluorometil)-1,4-diidrochinolina-3-carbossammide
GT200900014A (es) Derivados de i-(-d-glucopiranosil)-3-(4-ciclopropilfenilmetil)-4-halogeno indoly uso de los mismos como inhibidores de los transportadores de glucosa dependientes de sodio.
IL259387A (en) Mesoionic halogenated 3-(acetyl)-1-[(1,3-thiazol-5-yl)methyl]-1h-imidazo[1,2-a]pyridin-4-ium-2-olate derivatives and related compounds as insecticides
DK3880678T3 (da) Krystallinske former af p2x3-modulator methyl(s)-2-((2-(2,6-difluoro-4-(methylcarbamoyl )phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholin-4-carboxylat
DK2146991T3 (da) Triazolopyridin-carboxamid-derivater, fremstilling af samme samt terapeutisk anvendelse deraf
EA201270359A1 (ru) Терапевтическое средство от расстройств настроения
CY1122290T1 (el) Παραγωγο 2-ακυλαμινοθειαζολιου για χρηση στην προληψη ή αντιμετωπιση νοσων της ουροδοχου κυστης/του ουροποιητικου συστηματος
MX391445B (es) Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
DK3840832T3 (da) Imidazo[1,2-b]pyridaziner som trk-inhibitorer
EA202190405A1 (ru) КРИСТАЛЛИЧЕСКИЙ ПОЛИМОРФ 8-БРОМ-2-(1-МЕТИЛПИПЕРИДИН-4-ИЛАМИНО)-4-(4-ФЕНОКСИФЕНИЛАМИНО)ПИРИДО[4,3-d]ПИРИМИДИН-5(6H)-ОН ГИДРОХЛОРИДА И СПОСОБ ЕГО ПОЛУЧЕНИЯ
IL283823A (en) 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease
PE20190204A1 (es) [8-(fenilsulfonil)-3,8-diazabiciclo[3.2.1]oct-3-il](1h-1,2,3-triazol-4-il)metanonas
PL3924351T3 (pl) Postać krystaliczna chlorowodorku 2-((1r,4r)-4-((3-(3-(trifluorometylo)fenylo)imidazo[1,2-b]pirydazyn-6-ylo)amino)cykloheksylo)propan-2-olu dziedzina
DK3737684T3 (da) 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-on-derivater og relaterede forbindelser som c5a-receptormodulatorer til behandling af vaskulitis og inflammatoriske sygdomme
IL281025A (en) Processes for the preparation of 4-{8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl]imidazo[1,5-a]-pyrazin-1-yl}n-(pyridin-2-yl)-benzamide
DK3823972T3 (da) Imidazo[1,2-b]pyridazinderivater som trk-inhibitorer