MA56551A - Procédés et intermédiaires pour la production de composés de diazaspiro-lactame - Google Patents

Procédés et intermédiaires pour la production de composés de diazaspiro-lactame

Info

Publication number
MA56551A
MA56551A MA056551A MA56551A MA56551A MA 56551 A MA56551 A MA 56551A MA 056551 A MA056551 A MA 056551A MA 56551 A MA56551 A MA 56551A MA 56551 A MA56551 A MA 56551A
Authority
MA
Morocco
Prior art keywords
diazaspirolactam
intermediates
compounds
production
methods
Prior art date
Application number
MA056551A
Other languages
English (en)
Inventor
Khalid Diker
Danny T Dinh
William R Perrault
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of MA56551A publication Critical patent/MA56551A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA056551A 2019-06-24 2020-06-23 Procédés et intermédiaires pour la production de composés de diazaspiro-lactame MA56551A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962865840P 2019-06-24 2019-06-24

Publications (1)

Publication Number Publication Date
MA56551A true MA56551A (fr) 2022-04-27

Family

ID=74060351

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056551A MA56551A (fr) 2019-06-24 2020-06-23 Procédés et intermédiaires pour la production de composés de diazaspiro-lactame

Country Status (7)

Country Link
US (2) US12215114B2 (fr)
EP (2) EP3986400B1 (fr)
CN (2) CN114269338B (fr)
ES (1) ES2991258T3 (fr)
MA (1) MA56551A (fr)
TW (1) TWI887245B (fr)
WO (1) WO2020263848A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA56550A (fr) * 2019-06-24 2022-04-27 Naurex Inc Formes solides de tert-butyl (s)-2-((2s,3r)-1-amino-3-hydroxy-1-oxobu tan-2-yl)-1-oxo -2, 5-diazaspiro[3,4]octane-5-carboxylate et leurs procédés de préparation
US12215114B2 (en) 2019-06-24 2025-02-04 Naurex Inc. Processes and intermediates for producing diazaspiro lactam compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688787A (en) * 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
BRPI0918868B8 (pt) 2008-09-18 2021-05-25 Naurex Inc compostos moduladores do receptor de nmda e composições compreendendo os mesmos
CA2898863A1 (fr) 2013-01-29 2014-08-07 Naurex, Inc. Modulateurs spirolactames d'un recepteur nmda et leurs utilisations
CA2898861C (fr) 2013-01-29 2021-07-20 Naurex, Inc. Modulateurs spirolactames d'un recepteur nmda et leurs utilisations
CN105026401A (zh) * 2013-01-29 2015-11-04 诺雷克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
PH12015501596B1 (en) * 2013-01-29 2023-12-06 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
US20140238699A1 (en) 2013-02-22 2014-08-28 Vetco Gray Inc. Wellhead annulus seal having a wickered surface
EA201892657A1 (ru) * 2016-05-19 2019-05-31 Аптиникс Инк. Спиролактамовые модуляторы nmda-рецептора и их применение
WO2017201285A1 (fr) * 2016-05-19 2017-11-23 Aptinyx Inc. Modulateurs spirolactames des récepteurs nmda et leurs utilisations
WO2019152696A1 (fr) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactame modulateur de récepteurs nmda et leurs utilisations
MA56550A (fr) * 2019-06-24 2022-04-27 Naurex Inc Formes solides de tert-butyl (s)-2-((2s,3r)-1-amino-3-hydroxy-1-oxobu tan-2-yl)-1-oxo -2, 5-diazaspiro[3,4]octane-5-carboxylate et leurs procédés de préparation
US12215114B2 (en) 2019-06-24 2025-02-04 Naurex Inc. Processes and intermediates for producing diazaspiro lactam compounds

Also Published As

Publication number Publication date
EP3986400B1 (fr) 2024-08-21
CN120004904A (zh) 2025-05-16
EP3986400A4 (fr) 2023-05-17
US20250243211A1 (en) 2025-07-31
CN114269338B (zh) 2025-02-18
CN114269338A (zh) 2022-04-01
US12215114B2 (en) 2025-02-04
EP3986400C0 (fr) 2024-08-21
US20220259217A1 (en) 2022-08-18
TWI887245B (zh) 2025-06-21
ES2991258T3 (es) 2024-12-03
WO2020263848A1 (fr) 2020-12-30
EP3986400A1 (fr) 2022-04-27
EP4484431A2 (fr) 2025-01-01
TW202110852A (zh) 2021-03-16
EP4484431A3 (fr) 2025-03-26

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