MA62195B1 - Composition ayant une activité antitumoral obtenues à partir de dérivés de molécules d’extrait de la plante d’alfa - Google Patents

Composition ayant une activité antitumoral obtenues à partir de dérivés de molécules d’extrait de la plante d’alfa

Info

Publication number
MA62195B1
MA62195B1 MA62195A MA62195A MA62195B1 MA 62195 B1 MA62195 B1 MA 62195B1 MA 62195 A MA62195 A MA 62195A MA 62195 A MA62195 A MA 62195A MA 62195 B1 MA62195 B1 MA 62195B1
Authority
MA
Morocco
Prior art keywords
composition
alfa
molecules
derivatives
plant extract
Prior art date
Application number
MA62195A
Other languages
English (en)
Other versions
MA62195A1 (fr
Inventor
Mohamed Lahlou
Omar Cherkaoui
Bouchti Mehdi El
Original Assignee
École Supérieure Des Industries Du Textile Et De L'habillement (Esith)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by École Supérieure Des Industries Du Textile Et De L'habillement (Esith) filed Critical École Supérieure Des Industries Du Textile Et De L'habillement (Esith)
Priority to MA62195A priority Critical patent/MA62195B1/fr
Priority to PCT/MA2024/000003 priority patent/WO2025048625A1/fr
Publication of MA62195A1 publication Critical patent/MA62195A1/fr
Publication of MA62195B1 publication Critical patent/MA62195B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une Composition bioactive, à effet antitumoral, obtenue à partir de la transformation par réaction dalkylation et destérification dextrait de la plante de lalfa « Stipa tenacissima L ». Ladite composition comprend au moins un dérivé de lupéol et/ou du β-Sitostérol choisi parmi les formules (III) à (VI) obtenus par réaction dalkylation ou destérification avec un rendement de cytotoxicité très important.
MA62195A 2023-09-01 2023-09-01 Composition ayant une activité antitumoral obtenues à partir de dérivés de molécules d’extrait de la plante d’alfa MA62195B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MA62195A MA62195B1 (fr) 2023-09-01 2023-09-01 Composition ayant une activité antitumoral obtenues à partir de dérivés de molécules d’extrait de la plante d’alfa
PCT/MA2024/000003 WO2025048625A1 (fr) 2023-09-01 2024-02-14 Composition comprenant un derive de lupeol ou du beta-sitosterol pour son utilisation dans le traitement du cancer du sein ou du colon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MA62195A MA62195B1 (fr) 2023-09-01 2023-09-01 Composition ayant une activité antitumoral obtenues à partir de dérivés de molécules d’extrait de la plante d’alfa

Publications (2)

Publication Number Publication Date
MA62195A1 MA62195A1 (fr) 2025-03-28
MA62195B1 true MA62195B1 (fr) 2025-07-31

Family

ID=91960510

Family Applications (1)

Application Number Title Priority Date Filing Date
MA62195A MA62195B1 (fr) 2023-09-01 2023-09-01 Composition ayant une activité antitumoral obtenues à partir de dérivés de molécules d’extrait de la plante d’alfa

Country Status (2)

Country Link
MA (1) MA62195B1 (fr)
WO (1) WO2025048625A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119954885A (zh) * 2025-04-10 2025-05-09 中国中医科学院中医基础理论研究所 一种羽扇豆醇衍生物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53187A1 (fr) * 2021-05-03 2022-10-31 Ecole Superieure Des Ind Du Textile Et De Lhabillement Esith Composition bioactive à partir d'extraits de plante d'alfa à effet antitumoral et antioxydant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
KR102170307B1 (ko) * 2012-11-15 2020-10-26 주식회사 알엔에스 탈모방지 및 모발성장 촉진제 조성물
WO2020061317A1 (fr) * 2018-09-19 2020-03-26 Modernatx, Inc. Purification de stérol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53187A1 (fr) * 2021-05-03 2022-10-31 Ecole Superieure Des Ind Du Textile Et De Lhabillement Esith Composition bioactive à partir d'extraits de plante d'alfa à effet antitumoral et antioxydant

Also Published As

Publication number Publication date
MA62195A1 (fr) 2025-03-28
WO2025048625A1 (fr) 2025-03-06

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