MA66371B1 - Dérivés de s-alaninate substitués - Google Patents

Dérivés de s-alaninate substitués

Info

Publication number
MA66371B1
MA66371B1 MA66371A MA66371A MA66371B1 MA 66371 B1 MA66371 B1 MA 66371B1 MA 66371 A MA66371 A MA 66371A MA 66371 A MA66371 A MA 66371A MA 66371 B1 MA66371 B1 MA 66371B1
Authority
MA
Morocco
Prior art keywords
alaninate
derivatives
substituted
preparation
thrombotic
Prior art date
Application number
MA66371A
Other languages
English (en)
Inventor
Markus Follmann
Alexandros Vakalopoulos
Adrian Tersteegen
Alexander Hillisch
Stefan Heitmeier
Anja BUCHMÜLLER
Christoph Gerdes
Kersten Matthias Gericke
Frank SÜSSMEIER
Lars BÄRFACKER
Hartmut Beck
Guillaume Levilain
Stefanie Zimmermann
Lutz Lehmann
Stefanie MESCH
Nils PFAFF
Elisabeth KERSTEN
Katrin PARTIKEL
Andreas Peter BROEHL
Julia DIETZE-TORRES
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of MA66371B1 publication Critical patent/MA66371B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des dérivés de S-alaninate substitués et des procédés pour leur préparation, et également leur utilisation pour la préparation de médicaments pour le traitement et/ou la prophylaxie de maladies, en particulier de troubles vasculaires, de préférence de troubles thrombotiques ou thromboemboliques et/ou de complications thrombotiques ou thromboemboliques.
MA66371A 2021-09-03 2022-08-29 Dérivés de s-alaninate substitués MA66371B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21194781 2021-09-03
EP22769666.3A EP4396183B1 (fr) 2021-09-03 2022-08-29 Dérivés de s-alaninate substitués
PCT/EP2022/073889 WO2023031083A1 (fr) 2021-09-03 2022-08-29 Dérivés de s-alaninate substitués

Publications (1)

Publication Number Publication Date
MA66371B1 true MA66371B1 (fr) 2025-12-31

Family

ID=77640441

Family Applications (1)

Application Number Title Priority Date Filing Date
MA66371A MA66371B1 (fr) 2021-09-03 2022-08-29 Dérivés de s-alaninate substitués

Country Status (31)

Country Link
US (2) US20250002483A1 (fr)
EP (1) EP4396183B1 (fr)
JP (1) JP7546172B2 (fr)
KR (1) KR20240055043A (fr)
CN (1) CN117916236A (fr)
AR (1) AR126980A1 (fr)
AU (1) AU2022338082A1 (fr)
CA (1) CA3230721A1 (fr)
CL (1) CL2024000638A1 (fr)
CO (1) CO2024002668A2 (fr)
CR (1) CR20240114A (fr)
DK (1) DK4396183T3 (fr)
DO (1) DOP2024000024A (fr)
EC (1) ECSP24024658A (fr)
ES (1) ES3055022T3 (fr)
FI (1) FI4396183T3 (fr)
GE (2) GEAP202416491A (fr)
HR (1) HRP20251414T1 (fr)
IL (1) IL310777A (fr)
JO (1) JOP20240043A1 (fr)
LT (1) LT4396183T (fr)
MA (1) MA66371B1 (fr)
MX (1) MX2024002750A (fr)
PE (1) PE20240798A1 (fr)
PL (1) PL4396183T3 (fr)
PT (1) PT4396183T (fr)
RS (1) RS67431B1 (fr)
SI (1) SI4396183T1 (fr)
TW (1) TW202320754A (fr)
WO (1) WO2023031083A1 (fr)
ZA (1) ZA202402553B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4669644A1 (fr) * 2023-02-21 2025-12-31 Bayer Aktiengesellschaft Dérivés de s-alaninate substitués
WO2025237307A1 (fr) * 2024-05-14 2025-11-20 苏州康宁杰瑞生物科技有限公司 Inhibiteur du facteur de coagulation sanguine fxi/fxia pour le traitement de l'hypertension pulmonaire et/ou de l'hypertension
CN119366487A (zh) * 2024-10-30 2025-01-28 健帆生物科技集团股份有限公司 一种用于血液灌流器对内毒素吸附性能的评价方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042675A1 (fr) 1980-06-20 1981-12-30 Norton Company Procédé pour fixer une meule sur un arbre
CN102015675B (zh) * 2008-02-21 2014-07-02 赛诺菲 作为凝血因子Xa和凝血酶的抑制剂的氯噻吩-酰胺
US9637479B2 (en) 2013-04-26 2017-05-02 Sanofi Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide

Also Published As

Publication number Publication date
AR126980A1 (es) 2023-12-06
US20230391761A1 (en) 2023-12-07
US11912692B2 (en) 2024-02-27
SI4396183T1 (sl) 2026-01-30
JP2024509511A (ja) 2024-03-04
GEAP202416491A (en) 2024-05-10
CN117916236A (zh) 2024-04-19
ES3055022T3 (en) 2026-02-09
CR20240114A (es) 2024-05-22
GEP20257776B (en) 2025-06-25
JOP20240043A1 (ar) 2024-02-29
PE20240798A1 (es) 2024-04-18
EP4396183B1 (fr) 2025-09-03
PT4396183T (pt) 2025-11-25
ECSP24024658A (es) 2024-04-30
DK4396183T3 (da) 2025-11-17
CA3230721A1 (fr) 2023-03-09
WO2023031083A1 (fr) 2023-03-09
CO2024002668A2 (es) 2024-03-07
KR20240055043A (ko) 2024-04-26
HRP20251414T1 (hr) 2026-01-02
US20250002483A1 (en) 2025-01-02
RS67431B1 (sr) 2025-12-31
DOP2024000024A (es) 2024-03-28
CL2024000638A1 (es) 2024-07-05
MX2024002750A (es) 2024-03-27
EP4396183A1 (fr) 2024-07-10
IL310777A (en) 2024-04-01
LT4396183T (lt) 2025-11-25
AU2022338082A1 (en) 2024-02-15
TW202320754A (zh) 2023-06-01
JP7546172B2 (ja) 2024-09-05
FI4396183T3 (fi) 2025-12-04
ZA202402553B (en) 2025-09-25
PL4396183T3 (pl) 2026-02-09

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