MA67574A1 - Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires - Google Patents

Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires

Info

Publication number
MA67574A1
MA67574A1 MA67574A MA67574A MA67574A1 MA 67574 A1 MA67574 A1 MA 67574A1 MA 67574 A MA67574 A MA 67574A MA 67574 A MA67574 A MA 67574A MA 67574 A1 MA67574 A1 MA 67574A1
Authority
MA
Morocco
Prior art keywords
screening
inflammatory agents
quinoline
derived compounds
drugs
Prior art date
Application number
MA67574A
Other languages
English (en)
Inventor
Khaoula Mkhayar
Souad Elkhattabi
Kaouakeb Elkhattabi
Samir Chtita
Original Assignee
Université Sidi Mohammed Ben Abdellah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Université Sidi Mohammed Ben Abdellah filed Critical Université Sidi Mohammed Ben Abdellah
Priority to MA67574A priority Critical patent/MA67574A1/fr
Publication of MA67574A1 publication Critical patent/MA67574A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention vise à identifier une méthode de criblage des composés des dérivés de quinoléine autant que agents anti inflammatoire. Cette méthode intégrant des étapes enchainées notamment l'évaluation de la similitude avec les médicaments existants (Drug Likness), l'analyse de l'absorption, de la distribution, du métabolisme, de l'excrétion et de la toxicité (ADMET), ainsi que des études de Docking et de dynamique moléculaire pour teste les interactions entre la protéine phosphodiestérase 4 et le composé. Une base solide pour la poursuite d'expérimentations en vue de l'identification et de la conception de médicaments de nouvelle génération pour la thérapie ciblée contre les maladies inflammatoires.
MA67574A 2024-09-11 2024-09-11 Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires MA67574A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MA67574A MA67574A1 (fr) 2024-09-11 2024-09-11 Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MA67574A MA67574A1 (fr) 2024-09-11 2024-09-11 Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires

Publications (1)

Publication Number Publication Date
MA67574A1 true MA67574A1 (fr) 2026-03-31

Family

ID=99227571

Family Applications (1)

Application Number Title Priority Date Filing Date
MA67574A MA67574A1 (fr) 2024-09-11 2024-09-11 Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires

Country Status (1)

Country Link
MA (1) MA67574A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009087684A2 (fr) * 2008-01-04 2009-07-16 Panjab University Nouvelles tétrahydroquinoléines en tant qu'inhibiteurs d'aromatase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009087684A2 (fr) * 2008-01-04 2009-07-16 Panjab University Nouvelles tétrahydroquinoléines en tant qu'inhibiteurs d'aromatase

Similar Documents

Publication Publication Date Title
Fan et al. Role of homocysteine in the development and progression of Parkinson’s disease
Baran et al. Kynurenine metabolism in Alzheimer's disease
Durham et al. Target engagement in lead generation
EP1604203B1 (fr) Methodes de detection directe de metabolites de methotrexate individuels
US9187481B2 (en) (2S)-2-[[4-[(1R)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amin]pentanedioic acid for the treatment of inflammatory disorders
Daubeuf et al. An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice
CN110437147B (zh) 一种次氯酸双光子荧光探针hcp及其制备方法和应用
Chan et al. Quantification of a novel DNA–protein cross-link product formed by reacting apurinic/apyrimidinic sites in DNA with cysteine residues in protein by liquid chromatography-tandem mass spectrometry coupled with the stable isotope-dilution method
McClay et al. Neurochemical metabolomics reveals disruption to sphingolipid metabolism following chronic haloperidol administration
JP2020512356A (ja) ニコチンアミドｎ−メチルトランスフェラーゼ（ｎｎｍｔ）のキノリン由来小分子阻害剤及びその使用
Kim et al. Inhibitory effect of a 2, 4-bis (4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells
Gao et al. Reduning injection prevents carrageenan-induced inflammation in rats by serum and urine metabolomics analysis
MA67574A1 (fr) Méthode de criblage des composés dérivés de quinoléine autant que agents anti-inflammatoires
Garcia et al. Synthesis of deguelin–biotin conjugates and investigation into deguelin’s interactions
Kadaba et al. Triazolines—XXVII. Δ2-1, 2, 3-triazoline anticonvulsants: Novel ‘built-in’heterocyclic prodrugs with a unique ‘dual-action’mechanism for impairing excitatory amino acid l-glutamate neurotransmission
Bai et al. HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer's disease
EP3174545A1 (fr) Inhibition efficace de hsp27
Wei et al. Gut microbiota-mediated amino acid reprogramming in ketamine-induced neurotoxicity: A novel microbiota-amino acid-mitochondrial axis associated with cognitive deficits
US6391899B1 (en) Compounds and compositions for treating tissue ischemia
US11992497B2 (en) Cannabinoid derivatives and their use
Al-Soufi et al. Evaluating some biochemical parameters after repeated orally administration of levofloxacin in male rats
Ivanova et al. Anti-inflammatory activity of hemantane on peripheral inflammation and lipopolysaccharideinduced neuro-inflammation models
Harris et al. Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate
DE60006663D1 (de) Dihydrat eines purinderivates, medikamente die dieses als aktiven wirkstoff enthalten und zwischenprodukte zu dessen herstellung
Fu et al. Evolocumab (PCSK9 inhibitor) in hereditary spastic paraplegia type 5