MA69856B1 - Formes de sel citrate d'un agoniste du récepteur muscarinique - Google Patents
Formes de sel citrate d'un agoniste du récepteur muscariniqueInfo
- Publication number
- MA69856B1 MA69856B1 MA69856A MA69856A MA69856B1 MA 69856 B1 MA69856 B1 MA 69856B1 MA 69856 A MA69856 A MA 69856A MA 69856 A MA69856 A MA 69856A MA 69856 B1 MA69856 B1 MA 69856B1
- Authority
- MA
- Morocco
- Prior art keywords
- muscarinic receptor
- receptor agonist
- salts
- compounds
- salt forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés et des sels de ceux-ci qui sont des agonistes du récepteur muscarinique et qui sont utiles dans le traitement de maladies médiées par le récepteur muscarinique. L'invention concerne également des formes cristallines des composés et des sels de ceux-ci ; des compositions pharmaceutiques contenant les composés et les sels de ceux-ci, ou des formes cristallines associées ; des utilisations thérapeutiques des composés et des sels de ceux-ci, ou des formes cristallines associées ; des procédés de synthèse associés ; et des intermédiaires utiles pour lesdits procédés de synthèse.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2211399.7A GB202211399D0 (en) | 2022-08-04 | 2022-08-04 | Muscarinic receptor agonists |
| GBGB2305444.8A GB202305444D0 (en) | 2023-04-13 | 2023-04-13 | Muscarinic receptor agonists |
| GBGB2309615.9A GB202309615D0 (en) | 2023-06-26 | 2023-06-26 | Muscarinic receptor agonists |
| PCT/EP2023/071591 WO2024028458A2 (fr) | 2022-08-04 | 2023-08-03 | Agonistes du récepteur muscarinique |
| EP23757194.8A EP4508045B1 (fr) | 2022-08-04 | 2023-08-03 | Formes de sel citrate d'un agoniste du récepteur muscarinique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA69856B1 true MA69856B1 (fr) | 2025-10-31 |
Family
ID=87696205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA69856A MA69856B1 (fr) | 2022-08-04 | 2023-08-03 | Formes de sel citrate d'un agoniste du récepteur muscarinique |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20250340531A1 (fr) |
| EP (2) | EP4663190A3 (fr) |
| JP (1) | JP2025526601A (fr) |
| KR (1) | KR20250041066A (fr) |
| CN (1) | CN119866336A (fr) |
| AR (1) | AR130114A1 (fr) |
| AU (1) | AU2023317835A1 (fr) |
| CA (1) | CA3263797A1 (fr) |
| CL (1) | CL2025000299A1 (fr) |
| CO (1) | CO2025002413A2 (fr) |
| CR (1) | CR20250069A (fr) |
| DK (1) | DK4508045T3 (fr) |
| DO (1) | DOP2025000015A (fr) |
| ES (1) | ES3050097T3 (fr) |
| FI (1) | FI4508045T3 (fr) |
| HR (1) | HRP20251427T1 (fr) |
| IL (1) | IL318739A (fr) |
| JO (1) | JOP20250025A1 (fr) |
| LT (1) | LT4508045T (fr) |
| MA (1) | MA69856B1 (fr) |
| MD (1) | MD4508045T2 (fr) |
| MX (1) | MX2025001312A (fr) |
| PE (1) | PE20251236A1 (fr) |
| PL (1) | PL4508045T3 (fr) |
| PT (1) | PT4508045T (fr) |
| RS (1) | RS67422B1 (fr) |
| SI (1) | SI4508045T1 (fr) |
| SM (1) | SMT202600140T1 (fr) |
| TW (1) | TW202416955A (fr) |
| WO (1) | WO2024028458A2 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20260046441A (ko) * | 2023-08-03 | 2026-04-07 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 합성 방법 |
| WO2026050225A1 (fr) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Méthode de traitement d'une maladie ou d'un trouble neurologique ou psychiatrique |
| TW202615016A (zh) | 2024-08-27 | 2026-04-16 | 美商紐羅克里生物科學有限公司 | 醫藥調配物 |
| TW202615015A (zh) | 2024-08-27 | 2026-04-16 | 美商紐羅克里生物科學有限公司 | 特定毒蕈鹼受體激動劑之投與方法 |
| TW202619719A (zh) | 2024-08-27 | 2026-05-16 | 美商紐羅克里生物科學有限公司 | 治療方法 |
| WO2026050238A1 (fr) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Agoniste du récepteur muscarinique destiné à être utilisé dans le traitement d'un trouble neurologique ou psychiatrique |
| WO2026050236A1 (fr) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Agoniste du récepteur muscarinique en combinaison avec un inhibiteur du transporteur vésiculaire de la monoamine 2, destiné à être utilisé dans le traitement d'un trouble neurologique ou psychiatrique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104603124B (zh) * | 2012-08-10 | 2018-04-17 | 勃林格殷格翰国际有限公司 | 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 |
| RU2685230C2 (ru) | 2014-02-06 | 2019-04-17 | Хептарес Терапьютикс Лимитед | Бициклические азотсодержащие соединения как агонисты М1 мускариновых рецепторов |
-
2023
- 2023-08-03 CR CR20250069A patent/CR20250069A/es unknown
- 2023-08-03 MD MDE20250179T patent/MD4508045T2/ro unknown
- 2023-08-03 ES ES23757194T patent/ES3050097T3/es active Active
- 2023-08-03 WO PCT/EP2023/071591 patent/WO2024028458A2/fr not_active Ceased
- 2023-08-03 DK DK23757194.8T patent/DK4508045T3/da active
- 2023-08-03 US US18/867,575 patent/US20250340531A1/en active Pending
- 2023-08-03 SM SM20260140T patent/SMT202600140T1/it unknown
- 2023-08-03 EP EP25198643.6A patent/EP4663190A3/fr active Pending
- 2023-08-03 MA MA69856A patent/MA69856B1/fr unknown
- 2023-08-03 SI SI202330050T patent/SI4508045T1/sl unknown
- 2023-08-03 EP EP23757194.8A patent/EP4508045B1/fr active Active
- 2023-08-03 FI FIEP23757194.8T patent/FI4508045T3/fi active
- 2023-08-03 HR HRP20251427TT patent/HRP20251427T1/hr unknown
- 2023-08-03 AU AU2023317835A patent/AU2023317835A1/en active Pending
- 2023-08-03 IL IL318739A patent/IL318739A/en unknown
- 2023-08-03 CN CN202380057529.4A patent/CN119866336A/zh active Pending
- 2023-08-03 TW TW112129182A patent/TW202416955A/zh unknown
- 2023-08-03 PE PE2025000295A patent/PE20251236A1/es unknown
- 2023-08-03 RS RS20251164A patent/RS67422B1/sr unknown
- 2023-08-03 PT PT237571948T patent/PT4508045T/pt unknown
- 2023-08-03 LT LTEPPCT/EP2023/071591T patent/LT4508045T/lt unknown
- 2023-08-03 AR ARP230102050A patent/AR130114A1/es unknown
- 2023-08-03 JP JP2025505853A patent/JP2025526601A/ja active Pending
- 2023-08-03 KR KR1020257006895A patent/KR20250041066A/ko active Pending
- 2023-08-03 PL PL23757194.8T patent/PL4508045T3/pl unknown
- 2023-08-03 CA CA3263797A patent/CA3263797A1/fr active Pending
-
2025
- 2025-01-30 JO JOJO/P/2025/0025A patent/JOP20250025A1/ar unknown
- 2025-01-31 MX MX2025001312A patent/MX2025001312A/es unknown
- 2025-01-31 DO DO2025000015A patent/DOP2025000015A/es unknown
- 2025-01-31 CL CL2025000299A patent/CL2025000299A1/es unknown
- 2025-02-28 CO CONC2025/0002413A patent/CO2025002413A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023317835A1 (en) | 2025-03-20 |
| RS67422B1 (sr) | 2025-12-31 |
| WO2024028458A2 (fr) | 2024-02-08 |
| KR20250041066A (ko) | 2025-03-25 |
| CN119866336A (zh) | 2025-04-22 |
| WO2024028458A3 (fr) | 2024-03-21 |
| PT4508045T (pt) | 2025-10-29 |
| DK4508045T3 (da) | 2025-10-20 |
| TW202416955A (zh) | 2024-05-01 |
| FI4508045T3 (fi) | 2025-11-13 |
| SMT202600140T1 (it) | 2026-05-12 |
| MX2025001312A (es) | 2025-05-02 |
| EP4663190A3 (fr) | 2026-03-04 |
| US20250340531A1 (en) | 2025-11-06 |
| SI4508045T1 (sl) | 2025-11-28 |
| CA3263797A1 (fr) | 2024-02-08 |
| EP4508045A2 (fr) | 2025-02-19 |
| IL318739A (en) | 2025-03-01 |
| PL4508045T3 (pl) | 2026-03-23 |
| EP4663190A2 (fr) | 2025-12-17 |
| JP2025526601A (ja) | 2025-08-15 |
| AR130114A1 (es) | 2024-11-06 |
| ES3050097T3 (en) | 2025-12-19 |
| CO2025002413A2 (es) | 2025-06-16 |
| PE20251236A1 (es) | 2025-04-29 |
| CL2025000299A1 (es) | 2025-08-08 |
| EP4508045B1 (fr) | 2025-10-01 |
| JOP20250025A1 (ar) | 2025-01-30 |
| HRP20251427T1 (hr) | 2025-12-19 |
| LT4508045T (lt) | 2025-11-25 |
| CR20250069A (es) | 2025-05-26 |
| DOP2025000015A (es) | 2025-04-08 |
| MD4508045T2 (ro) | 2026-01-31 |
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