MA71363A - L'acide 1-hydroxy-4-(trifluorométhyl)-1,3-dihydrobenzo[c] [1,2]oxaborole-6-carboxylique et son utilisation dans la synthèse de dérivés de liaison à l'albumine sensibles au glucose - Google Patents

L'acide 1-hydroxy-4-(trifluorométhyl)-1,3-dihydrobenzo[c] [1,2]oxaborole-6-carboxylique et son utilisation dans la synthèse de dérivés de liaison à l'albumine sensibles au glucose

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Publication number
MA71363A
MA71363A MA71363A MA71363A MA71363A MA 71363 A MA71363 A MA 71363A MA 71363 A MA71363 A MA 71363A MA 71363 A MA71363 A MA 71363A MA 71363 A MA71363 A MA 71363A
Authority
MA
Morocco
Prior art keywords
oxaborole
dihydrobenzo
trifluoromethyl
glucose
hydroxy
Prior art date
Application number
MA71363A
Other languages
English (en)
Inventor
Mikael Kofod-Hansen
Henning THØGERSEN
Thomas Kruse
Per Sauerberg
Carsten Behrens
Vojtech BALSÁNEK
Zuzana DROBNÁKOVÁ
Miroslav HAVRÁNEK
Vladislav KOTEK
Milan STENGL
Ivan Snajdr
Hana VÁNOVÁ
Thomas HØEG-JENSEN
Martin Werner Borchsenius MÜNZEL
Jakob Ewald Rasmussen
Ladislav Droz
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of MA71363A publication Critical patent/MA71363A/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00Condition responsive control processes
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/10Methods of screening libraries by measuring physical properties, e.g. mass
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827Total protein determination, e.g. albumin in urine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA71363A 2017-11-09 2018-11-08 L'acide 1-hydroxy-4-(trifluorométhyl)-1,3-dihydrobenzo[c] [1,2]oxaborole-6-carboxylique et son utilisation dans la synthèse de dérivés de liaison à l'albumine sensibles au glucose MA71363A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17200734 2017-11-09
EP18178294 2018-06-18
EP23172873.4A EP4227313B1 (fr) 2017-11-09 2018-11-08 L'acide 1-hydroxy-4-(trifluorométhyl)-1,3-dihydrobenzo[c] [1,2]oxaborole-6-carboxylique et son utilisation dans la synthèse de dérivés de liaison à l'albumine sensibles au glucose

Publications (1)

Publication Number Publication Date
MA71363A true MA71363A (fr) 2025-04-30

Family

ID=64049277

Family Applications (2)

Application Number Title Priority Date Filing Date
MA71363A MA71363A (fr) 2017-11-09 2018-11-08 L'acide 1-hydroxy-4-(trifluorométhyl)-1,3-dihydrobenzo[c] [1,2]oxaborole-6-carboxylique et son utilisation dans la synthèse de dérivés de liaison à l'albumine sensibles au glucose
MA050552A MA50552A (fr) 2017-11-09 2018-11-08 Dérivés de liaison à l'albumine sensibles au glucose

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA050552A MA50552A (fr) 2017-11-09 2018-11-08 Dérivés de liaison à l'albumine sensibles au glucose

Country Status (7)

Country Link
US (4) US11186595B2 (fr)
EP (2) EP4227313B1 (fr)
JP (3) JP7254792B2 (fr)
CN (2) CN111315751B (fr)
ES (2) ES3056386T3 (fr)
MA (2) MA71363A (fr)
WO (1) WO2019092125A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016179568A1 (fr) 2015-05-06 2016-11-10 Protomer Technologies, Inc. Insulines sensibles au glucose
WO2019092125A1 (fr) * 2017-11-09 2019-05-16 Novo Nordisk A/S Dérivés de liaison à l'albumine sensibles au glucose
EP3946363A2 (fr) * 2019-03-29 2022-02-09 Novo Nordisk A/S Dérivés d'insuline sensibles au glucose
CN112174989B (zh) * 2019-07-02 2023-06-20 江西同和药业股份有限公司 一种克立硼罗的制备方法
JP7834341B2 (ja) * 2019-07-31 2026-03-24 シーエス ファーマシューティカルズ エルエルシー グルコース調節型立体配座スイッチを有するインスリン類似体
EP4126058A1 (fr) * 2020-03-31 2023-02-08 Protomer Technologies Inc. Conjugués pour une réactivité sélective à des diols vicinaux
JP2024500284A (ja) * 2020-11-19 2024-01-09 プロトマー・テクノロジーズ・インコーポレイテッド 芳香族ホウ素含有化合物及びインスリン類似体
EP4255468A4 (fr) * 2020-12-02 2024-06-05 The Regents of University of California Complexe polymère biodégradable injectable pour l'administration d'insuline sensible au glucose
WO2022235691A1 (fr) * 2021-05-03 2022-11-10 The Trustees Of Indiana University Conception moléculaire de capteurs de glucose dans des analogues d'insuline sensibles au glucose
CN114478597B (zh) * 2021-12-29 2023-08-29 宁波大学 一种快速识别葡萄糖手性的试剂及其制备方法和应用
WO2023225534A1 (fr) 2022-05-18 2023-11-23 Protomer Technologies Inc. Composés contenant du bore aromatiques et analogues d'insuline associés
AU2024251658A1 (en) * 2023-04-11 2025-09-18 Protomer Technologies, Inc. Compounds containing one or more diboronates and related insulin analogs
AU2024295902A1 (en) 2023-07-18 2026-01-15 Novo Nordisk A/S Pharmaceutical compositions of insulin derivatives

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628674B2 (en) 1989-10-19 1992-09-17 Nippon Oil And Fats Company, Limited Polymer complexes of a sugar response type
AU2001263775A1 (en) 2000-06-02 2001-12-11 Novo-Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
EP1453860A2 (fr) 2001-12-02 2004-09-08 Novo Nordisk A/S Nouvelles insulines gluco-dependantes
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
AU2003223930A1 (en) 2002-06-14 2003-12-31 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
WO2009112583A2 (fr) 2008-03-14 2009-09-17 Novo Nordisk A/S Analogues de l’insuline stabilisés une protéase
DE102008052314A1 (de) * 2008-10-15 2010-04-22 Syntatec Chemicals Gmbh Aromatische und heteroaromatische Poly-trifluoroborate und Verfahren zur Herstellung
WO2011000823A1 (fr) 2009-06-30 2011-01-06 Novo Nordisk A/S Dérivés de l'insuline
TWI458732B (zh) * 2012-06-27 2014-11-01 國立交通大學 具硼酸基團連接子及含有其之生物感測元件
WO2014093696A2 (fr) 2012-12-12 2014-06-19 Massachusetts Institute Of Technology Dérivés d'insuline pour le traitement du diabète
WO2015097276A1 (fr) * 2013-12-23 2015-07-02 Syngenta Participations Ag Fongicides benzoxaborole
WO2015106292A1 (fr) * 2014-01-13 2015-07-16 Coferon, Inc. Ligands de tyrosine-kinase bcr-abl capables de se dimériser dans une solution aqueuse, et procédés d'utilisation de ceux-ci
AR103397A1 (es) * 2015-01-13 2017-05-10 Syngenta Participations Ag Oxoborazoles microbicidas
JP6914844B2 (ja) 2015-03-13 2021-08-04 ケース ウェスタン リザーブ ユニバーシティCase Western Reserve University グルコース制御立体配座スイッチを含むインスリン類似体
WO2016179568A1 (fr) 2015-05-06 2016-11-10 Protomer Technologies, Inc. Insulines sensibles au glucose
UA121354C2 (uk) * 2016-05-12 2020-05-12 Анакор Фармасутікалз, Інк. Нові сполуки для лікування паразитарних захворювань
US10690675B2 (en) * 2017-04-14 2020-06-23 Georgia Tech Research Corporation Methods for enriching glycopeptides for global analysis of glycoproteins
WO2019092125A1 (fr) * 2017-11-09 2019-05-16 Novo Nordisk A/S Dérivés de liaison à l'albumine sensibles au glucose
EP3781147A4 (fr) 2018-04-16 2022-04-20 University of Utah Research Foundation Insuline sensible au glucose

Also Published As

Publication number Publication date
EP4227313C0 (fr) 2025-10-22
US20220081451A1 (en) 2022-03-17
US11186595B2 (en) 2021-11-30
EP3707145A1 (fr) 2020-09-16
JP2021502372A (ja) 2021-01-28
EP4227313A1 (fr) 2023-08-16
CN117624207A (zh) 2024-03-01
MA50552A (fr) 2020-09-16
ES3056386T3 (en) 2026-02-20
CN111315751B (zh) 2023-12-12
JP7254792B2 (ja) 2023-04-10
US20230331745A1 (en) 2023-10-19
CN111315751A (zh) 2020-06-19
US20250122226A1 (en) 2025-04-17
US20200325160A1 (en) 2020-10-15
US11767332B2 (en) 2023-09-26
JP2023080126A (ja) 2023-06-08
EP4227313B1 (fr) 2025-10-22
EP3707145B1 (fr) 2023-06-21
US12227528B2 (en) 2025-02-18
ES2956032T3 (es) 2023-12-12
JP2025061325A (ja) 2025-04-10
EP3707145C0 (fr) 2023-06-21
JP7622123B2 (ja) 2025-01-27
WO2019092125A1 (fr) 2019-05-16

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