MA71390A - Compositions pharmaceutiques comprenant des inhibiteurs de l'hélicase wrn - Google Patents

Compositions pharmaceutiques comprenant des inhibiteurs de l'hélicase wrn

Info

Publication number
MA71390A
MA71390A MA71390A MA71390A MA71390A MA 71390 A MA71390 A MA 71390A MA 71390 A MA71390 A MA 71390A MA 71390 A MA71390 A MA 71390A MA 71390 A MA71390 A MA 71390A
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
helicase inhibitors
wrn helicase
wrn
inhibitors
Prior art date
Application number
MA71390A
Other languages
English (en)
Inventor
Betty Lam
Shota Kikuchi
Jason Green
Don ROGNESS
David Weinstein
Larry Burgess
Benjamin HORNING
Kelsey LAMB
Zachary Owyang
Robert MALMSTROM
Original Assignee
Vividion Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vividion Therapeutics, Inc. filed Critical Vividion Therapeutics, Inc.
Publication of MA71390A publication Critical patent/MA71390A/fr

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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MA71390A 2022-07-06 2023-07-05 Compositions pharmaceutiques comprenant des inhibiteurs de l'hélicase wrn MA71390A (fr)

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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025072451A1 (fr) * 2023-09-27 2025-04-03 Vividion Therapeutics, Inc. Inhibiteurs de ras-pi3k pour le traitement du cancer et de maladies immunologiques
WO2025067429A1 (fr) * 2023-09-28 2025-04-03 InventisBio Co., Ltd. Composés, leurs procédés de préparation et leurs utilisations
WO2025073792A1 (fr) 2023-10-02 2025-04-10 Forx Therapeutics Ag Composés inhibiteurs de wrn
WO2025096957A1 (fr) * 2023-11-03 2025-05-08 Vividion Therapeutics, Inc. Inhibiteurs de ras-pi3k et leurs utilisations
WO2025133395A1 (fr) 2023-12-22 2025-06-26 Forx Therapeutics Ag Composés inhibiteurs bicycliques (hétéro)arylène wrn
WO2025149547A1 (fr) * 2024-01-11 2025-07-17 F. Hoffmann-La Roche Ag Nouvelles formes solides de n-[(1s,2e)-1-cyclopropyl-3-(méthanesulfonyl)prop-2-en-1-yl]-2-(1,1-difluoroéthyl)-4-phénoxypyrimidine-5-carboxamide
WO2025149544A1 (fr) * 2024-01-11 2025-07-17 F. Hoffmann-La Roche Ag Procédé de préparation de n-[(1s,2e)-1-cyclopropyl-3-(méthanesulfonyl)prop-2-en-1-yl]-2-(1,1-difluoroéthyl)-4-phénoxypyrimidine-5-carboxamide
WO2025191176A1 (fr) 2024-03-14 2025-09-18 Forx Therapeutics Ag Composés inhibiteurs de wrn
WO2025190405A1 (fr) * 2024-03-15 2025-09-18 南京再明医药有限公司 Composé inhibiteur de wrn contenant de l'azote et son utilisation
WO2025191054A1 (fr) 2024-03-15 2025-09-18 F. Hoffmann-La Roche Ag (s,e)-n-(1-cyclopropyl-3-(méthylsulfonyl)allyl)-2-(1,1-difluoroéthyl)-4-phénoxypyrimidine-5-carboxamide pour le traitement du cancer
TW202600531A (zh) * 2024-04-26 2026-01-01 大陸商上海濟煜醫藥科技有限公司 作為wrn解旋酶抑制劑的芳香族醯胺類化合物及其製備方法和應用
WO2025232693A1 (fr) * 2024-05-08 2025-11-13 Nuphase Therapeutics (Shanghai) Limited., Co. Nouveaux composés, compositions les comprenant et leurs utilisations
WO2025247373A1 (fr) * 2024-05-31 2025-12-04 Laekna Pharmaceutical Ningbo Co., Ltd. Composés cycliques fusionnés et leur utilisation en tant qu'inhibiteurs de l'hélicase wrn
WO2025261470A1 (fr) * 2024-06-21 2025-12-26 南京再明医药有限公司 Composé sulfonyle et son utilisation
WO2025261481A1 (fr) * 2024-06-21 2025-12-26 南京再明医药有限公司 Composé hétéroaromatique à cinq chaînons et son utilisation
WO2025261486A1 (fr) * 2024-06-22 2025-12-26 InventisBio Co., Ltd. Composés, leurs procédés de préparation et leurs utilisations
WO2026003380A1 (fr) 2024-06-28 2026-01-02 Forx Therapeutics Ag Composés inhibiteurs de wrn
WO2026002176A1 (fr) * 2024-06-28 2026-01-02 武汉人福创新药物研发中心有限公司 Composé contenant un cycle aromatique utilisé en tant qu'inhibiteur de wrn et son utilisation
WO2026006805A1 (fr) * 2024-06-28 2026-01-02 Amgen Inc. Composés à noyau à 6 chaînons utilisés comme modulateurs de l'hélicase à adn recq du syndrome de werner et leurs utilisations
WO2026010876A1 (fr) 2024-07-01 2026-01-08 Moma Therapeutics, Inc. Modulateurs d'hélicase wrn et leurs procédés d'utilisation
CN121627616A (zh) * 2024-08-30 2026-03-10 广州科恩泰生物医药科技有限公司 一种抑制wrn解旋酶的含氮化合物、含其的药物组合物及其应用
CN119039191B (zh) * 2024-09-20 2026-03-10 上海信诺维生物医药有限公司 一类含有亚砜结构的化合物
CN119039190B (zh) * 2024-09-20 2026-03-10 上海信诺维生物医药有限公司 一种wrn抑制剂

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
CA2406864A1 (fr) 2000-02-24 2001-08-30 Life Technologies Corporation Stimulation et concentration simultanees de cellules
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
EP1761629A2 (fr) * 2004-05-19 2007-03-14 Trustees Of Boston University Modulation de signalisation cellulaire initiee par telomere medie par wrn
GB0609498D0 (en) 2006-05-12 2006-06-21 Oncomethylome Sciences S A Novel methylation marker
MX2020013120A (es) 2018-06-04 2021-07-21 Broad Inst Inc Tratamiento terapéutico de cánceres de microsatélites inestables.
WO2019241802A2 (fr) * 2018-06-15 2019-12-19 Ideaya Biosciences, Inc. Procédés d'inhibition de cellules prolifératives
CA3118752A1 (fr) * 2018-11-09 2020-05-14 Vivace Therapeutics, Inc. Composes bicycliques
WO2022006534A1 (fr) * 2020-07-02 2022-01-06 The Brigham And Women's Hospital, Inc. Ciblage de serpine b9 dans le cancer
WO2023062575A1 (fr) * 2021-10-14 2023-04-20 Ideaya Biosciences, Inc. Composés de sulfone de vinyle cyclique utilisés en tant qu'inhibiteurs de wrn

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US20250188040A1 (en) 2025-06-12
CL2024004021A1 (es) 2025-05-16
MX2024015753A (es) 2025-04-02
AU2023305006A1 (en) 2024-12-19
JP2025118686A (ja) 2025-08-13
WO2024010782A1 (fr) 2024-01-11
TW202409001A (zh) 2024-03-01
JP7818138B2 (ja) 2026-02-19
JP2025522911A (ja) 2025-07-17
PE20251109A1 (es) 2025-04-22
IL317985A (en) 2025-02-01
US20240140915A1 (en) 2024-05-02
CN119677716A (zh) 2025-03-21
CA3259658A1 (fr) 2024-01-11
AR129853A1 (es) 2024-10-02
CR20240549A (es) 2025-05-09
US12187685B2 (en) 2025-01-07

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