MC2186A1 - Complexes d'inclusion de 3-morpholino-sydnonimine ou de ses sels ou de son isomere tautomere,procede de preparation de tels complexes et compositions pharmaceutiques contenant de tels complexes - Google Patents

Complexes d'inclusion de 3-morpholino-sydnonimine ou de ses sels ou de son isomere tautomere,procede de preparation de tels complexes et compositions pharmaceutiques contenant de tels complexes

Info

Publication number
MC2186A1
MC2186A1 MC@@@@D MC2186D MC2186A1 MC 2186 A1 MC2186 A1 MC 2186A1 MC 2186 D MC2186 D MC 2186D MC 2186 A1 MC2186 A1 MC 2186A1
Authority
MC
Monaco
Prior art keywords
complexes
sydnonimine
morpholino
salts
pharmaceutical compositions
Prior art date
Application number
MC@@@@D
Other languages
English (en)
Inventor
Vikmon Maria
Szejtli Jozsef
Szente Lajos
Gaal Jozsef
Hermecz Istvan
Hovarth Agnes
Marmarost Katalin
Hovarth Gabor
Munkacsi Iren
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of MC2186A1 publication Critical patent/MC2186A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MC@@@@D 1990-03-28 1991-03-28 Complexes d'inclusion de 3-morpholino-sydnonimine ou de ses sels ou de son isomere tautomere,procede de preparation de tels complexes et compositions pharmaceutiques contenant de tels complexes MC2186A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU901869A HU212730B (en) 1990-03-28 1990-03-28 Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them
PCT/HU1991/000013 WO1991014681A1 (fr) 1990-03-28 1991-03-28 Complexes d'inclusion de 3-morpholino-sydnonimine ou de ses sels ou de son isomere tautomere, procede de preparation de tels complexes et compositions pharmaceutiques contenant de tels complexes

Publications (1)

Publication Number Publication Date
MC2186A1 true MC2186A1 (fr) 1992-09-16

Family

ID=10956597

Family Applications (1)

Application Number Title Priority Date Filing Date
MC@@@@D MC2186A1 (fr) 1990-03-28 1991-03-28 Complexes d'inclusion de 3-morpholino-sydnonimine ou de ses sels ou de son isomere tautomere,procede de preparation de tels complexes et compositions pharmaceutiques contenant de tels complexes

Country Status (32)

Country Link
US (1) US5298496A (fr)
EP (1) EP0478732B1 (fr)
JP (1) JP2549961B2 (fr)
KR (1) KR950004706B1 (fr)
CN (1) CN1051081C (fr)
AT (1) ATE170849T1 (fr)
AU (1) AU635835B2 (fr)
BG (1) BG61812B1 (fr)
BR (1) BR9105137A (fr)
CA (1) CA2054213C (fr)
CZ (1) CZ285695B6 (fr)
DE (1) DE69130146T2 (fr)
DK (1) DK0478732T3 (fr)
ES (1) ES2121780T3 (fr)
FI (1) FI104882B (fr)
GE (1) GEP19991743B (fr)
HR (1) HRP920560B1 (fr)
HU (2) HU211648A9 (fr)
LT (1) LT3257B (fr)
LV (1) LV10087B (fr)
MC (1) MC2186A1 (fr)
MD (1) MD776C2 (fr)
MW (1) MW6891A1 (fr)
NO (1) NO303634B1 (fr)
OA (1) OA09522A (fr)
PL (1) PL165866B1 (fr)
RO (1) RO109336B1 (fr)
RU (1) RU2107695C1 (fr)
SI (1) SI9110909B (fr)
TJ (1) TJ189R3 (fr)
UA (1) UA27242C2 (fr)
WO (1) WO1991014681A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210921B (en) * 1990-03-28 1995-09-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
DE4117249C2 (de) * 1991-05-27 1998-05-14 Christian Dr Stief Linsidomin zur Behandlung erektiler Dysfunktionen
HU213200B (en) 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
HU218280B (en) * 1994-04-26 2000-07-28 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
AU2001255709A1 (en) * 2000-05-11 2001-11-20 Eastman Chemical Company Acylated cyclodextrin guest inclusion complexes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1496056A (fr) * 1964-06-08 1967-09-29 Takeda Chemical Industries Ltd Nouveaux composés chimiques du type sydnonimine
DE3221425A1 (de) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette
DE3346638A1 (de) * 1983-12-23 1985-07-04 Cassella Ag, 6000 Frankfurt Photostabilisierung von molsidomin
DE3346614A1 (de) * 1983-12-23 1985-07-04 Anton Hummel Gmbh Metallwarenfabrik, 7808 Waldkirch Entlueftungsventil insbesondere zum entlueften von heizsystemen
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
DE3522191A1 (de) * 1985-06-21 1987-01-15 Cassella Ag Photostabilisierung von sydnoniminen
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
WO1991015346A1 (fr) * 1990-04-06 1991-10-17 Gerhard Blatt Installation servant au conditionnement de blocs de beton

Also Published As

Publication number Publication date
CN1051081C (zh) 2000-04-05
FI104882B (fi) 2000-04-28
ATE170849T1 (de) 1998-09-15
CA2054213C (fr) 1998-12-01
DK0478732T3 (da) 1999-06-07
LT3257B (en) 1995-05-25
HU211648A9 (en) 1995-12-28
BR9105137A (pt) 1992-08-04
AU7549391A (en) 1991-10-21
AU635835B2 (en) 1993-04-01
PL165866B1 (pl) 1995-02-28
RU2107695C1 (ru) 1998-03-27
CZ85291A3 (en) 1993-11-17
EP0478732B1 (fr) 1998-09-09
SI9110909B (sl) 1999-02-28
HRP920560A2 (hr) 1994-04-30
KR920701183A (ko) 1992-08-11
RO109336B1 (ro) 1995-01-30
TJ189R3 (en) 1998-10-28
UA27242C2 (uk) 2000-08-15
CN1055928A (zh) 1991-11-06
HU212730B (en) 1996-10-28
FI915570A0 (fi) 1991-11-26
JPH04506221A (ja) 1992-10-29
BG61812B1 (bg) 1998-06-30
MD776B2 (en) 1997-07-31
NO914650D0 (no) 1991-11-27
WO1991014681A1 (fr) 1991-10-03
MD776C2 (ro) 1998-05-31
LTIP387A (en) 1994-09-25
DE69130146T2 (de) 1999-04-01
NO914650L (no) 1991-11-27
CA2054213A1 (fr) 1991-09-29
HRP920560B1 (en) 1999-12-31
CZ285695B6 (cs) 1999-10-13
KR950004706B1 (ko) 1995-05-04
NO303634B1 (no) 1998-08-10
LV10087A (lv) 1994-05-10
US5298496A (en) 1994-03-29
MW6891A1 (en) 1993-07-14
HK1011688A1 (en) 1999-07-16
MD940334A (en) 1996-10-31
EP0478732A1 (fr) 1992-04-08
GEP19991743B (en) 1999-09-10
PL293020A1 (en) 1992-12-28
DE69130146D1 (de) 1998-10-15
HU901869D0 (en) 1990-07-28
JP2549961B2 (ja) 1996-10-30
ES2121780T3 (es) 1998-12-16
SI9110909A (sl) 1998-06-30
LV10087B (en) 1995-02-20
HUT58110A (en) 1992-01-28
BG95530A (bg) 1993-12-24
OA09522A (en) 1992-11-15

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