MD113C2 - Method of obtaining of phenylkylamine or of salts of this compounds - Google Patents
Method of obtaining of phenylkylamine or of salts of this compoundsInfo
- Publication number
- MD113C2 MD113C2 MD94-0331A MD940331A MD113C2 MD 113 C2 MD113 C2 MD 113C2 MD 940331 A MD940331 A MD 940331A MD 113 C2 MD113 C2 MD 113C2
- Authority
- MD
- Moldova
- Prior art keywords
- alkyl
- carbon atoms
- general formula
- linear
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- -1 sulphonic acid ester Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the organic synthesis and concerns the obtaining of new phenylalkylamines with a biological activity and which may be used in pharmaceutical preparations which stimulate nervous system. The purpose of invention consists in the prepairation of stimulators with a new spectrum of actions.The method of obtaining phenylalkylamines is of general formula 1:wherein R1 represents C2-C8-alkyl with linear or branched chain, C7-C10-phenylalkyl, cycloalkyl C3-C8-phenyl, R2 represents C1-C8 alkyl with linear or branched chain, C1-C8-alkyl, substitutes by H, OH atom, with alkoxygroup which consists of 1 to 4 carbon atoms, alkyl with 3 carbon atoms and C3-C8-cycloalkyl substituted by phenyl provided that R1 and R2 groups contain together at least 5 carbon atoms and when R1 represents ethyl, R2 can not be isobutyl, or salts of these compounds by interaction of amine with general formula II:wherein R1 has the above indicated meaning with a compound of general formula III:wherein X represents halogen atom or the residue of sulphonic acid ester, R3 represents H atom or C1-C7-alkyl with linear or branched chain, C1-C7-alkyl substituted by halogen atom, OH, alkoxygroup with 1-4 carbon atoms, alkyl with 2 carbon atoms, substituted by phenyl:R4 represents H or R3 and B4 represents alkyl provided that R3 and R4 contain together no more than 7 carbon atoms, or R3 and R4 together with CH can form cycloalkyl nucleus with 3-8 carbon atoms. As agent with fixed acide is used an amino excess, organic base or unorganic or alkaline ion exchanger.The product separates in free form or under the shape of salt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864101A HU207280B (en) | 1986-09-25 | 1986-09-25 | Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them |
| PCT/HU1987/000040 WO1988002254A1 (en) | 1986-09-25 | 1987-09-25 | New psychostimulant agent |
| SU904830945A RU2015960C1 (en) | 1986-09-25 | 1990-09-10 | Process for preparing phenylkylamines or salts of these compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD113B1 MD113B1 (en) | 1994-12-31 |
| MD113C2 true MD113C2 (en) | 1995-11-30 |
Family
ID=26317738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0331A MD113C2 (en) | 1986-09-25 | 1994-08-25 | Method of obtaining of phenylkylamine or of salts of this compounds |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD113C2 (en) |
-
1994
- 1994-08-25 MD MD94-0331A patent/MD113C2/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| М.Д. Машковский. Лекарсвтенные средства. vol. I, М. Медицина, 1986, р. 110. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD113B1 (en) | 1994-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 1M4A | Expiration of terms |