MD1419G2 - Complecşi de incluziune pe bază de SIN-1A şi ciclodextrină, compoziţii farmaceutice şi truse pe baza lor, procedeu de preparare a complecşilor de incluziune şi metodă de tratament - Google Patents
Complecşi de incluziune pe bază de SIN-1A şi ciclodextrină, compoziţii farmaceutice şi truse pe baza lor, procedeu de preparare a complecşilor de incluziune şi metodă de tratament Download PDFInfo
- Publication number
- MD1419G2 MD1419G2 MD95-0440A MD950440A MD1419G2 MD 1419 G2 MD1419 G2 MD 1419G2 MD 950440 A MD950440 A MD 950440A MD 1419 G2 MD1419 G2 MD 1419G2
- Authority
- MD
- Moldova
- Prior art keywords
- complexes
- sin
- cyclodextrin
- base
- kits
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- NCGICGYLBXGBGN-UHFFFAOYSA-N 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride Chemical compound Cl.[N-]1OC(=N)C=[N+]1N1CCOCC1 NCGICGYLBXGBGN-UHFFFAOYSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- GSKDBLIBBOYOFU-UHFFFAOYSA-N oxadiazol-5-amine Chemical compound NC1=CN=NO1 GSKDBLIBBOYOFU-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Invenţia se referă la noi complecşi de incluziune, stabili în stare solidă, obţinuţi din forma deschisă a sidnoniminei SIN-1A şi ciclodextrine sau derivaţii lor, care eventual mai conţin ioni, drept catalizatori sau stabilizatori. Complecşii eliberează oxid de azot la temperatura camerei prin dizolvare în apă sau în sisteme apoase.Sunt revendicate de asemenea compoziţii farmaceutice şi truse care conţin aceşti complecşi. Trusele se utilizează ca standarde de eliberare de NO într-o cantitate şi cu un debit previzibil la dizolvare în medii apoase.Invenţia se referă şi la procedeul de preparare a complecşilor prin supunerea SIN-1 acţiunii catalitice a ionilor la un pH potrivit, pentru a deplasa echilibrul spre formarea a SIN-1A în prezenţa moleculelor-gazdă, care este imediat complexat şi stabilizat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9401183A HU218280B (en) | 1994-04-26 | 1994-04-26 | Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes |
| PCT/HU1995/000011 WO1995029172A1 (en) | 1994-04-26 | 1995-04-25 | N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD950440A MD950440A (ro) | 1997-10-31 |
| MD1419F2 MD1419F2 (ro) | 2000-02-29 |
| MD1419G2 true MD1419G2 (ro) | 2000-11-30 |
Family
ID=10985114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0440A MD1419G2 (ro) | 1994-04-26 | 1995-04-25 | Complecşi de incluziune pe bază de SIN-1A şi ciclodextrină, compoziţii farmaceutice şi truse pe baza lor, procedeu de preparare a complecşilor de incluziune şi metodă de tratament |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5698535A (ro) |
| EP (1) | EP0705255B1 (ro) |
| JP (1) | JP3434828B2 (ro) |
| KR (1) | KR960703404A (ro) |
| CN (1) | CN1060164C (ro) |
| AT (1) | ATE197708T1 (ro) |
| AU (1) | AU694219B2 (ro) |
| BG (1) | BG61974B1 (ro) |
| BR (1) | BR9506155A (ro) |
| CA (1) | CA2163539C (ro) |
| CZ (1) | CZ316395A3 (ro) |
| DE (1) | DE69519463T2 (ro) |
| DK (1) | DK0705255T3 (ro) |
| ES (1) | ES2153897T3 (ro) |
| FI (1) | FI956156A0 (ro) |
| GR (1) | GR3035356T3 (ro) |
| HR (1) | HRP950249A2 (ro) |
| HU (1) | HU218280B (ro) |
| IL (1) | IL113491A (ro) |
| LT (1) | LT4167B (ro) |
| LV (1) | LV11543B (ro) |
| MD (1) | MD1419G2 (ro) |
| NO (1) | NO311030B1 (ro) |
| NZ (1) | NZ285149A (ro) |
| PL (1) | PL312183A1 (ro) |
| PT (1) | PT705255E (ro) |
| RO (1) | RO114449B1 (ro) |
| RU (1) | RU2136698C1 (ro) |
| SI (1) | SI0705255T1 (ro) |
| SK (1) | SK155195A3 (ro) |
| WO (1) | WO1995029172A1 (ro) |
| YU (1) | YU25995A (ro) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
| CA2391008C (en) * | 1999-11-12 | 2009-12-22 | Pitha & Pitha Llc | Crystalline mixtures of partial methyl ethers of beta-cyclodextrin and related compounds |
| FR2805462B1 (fr) * | 2000-02-24 | 2003-08-15 | Therabel Res | Nouvelle forme galenique orale a liberation prolongee de la molsidomine |
| TWI321054B (en) * | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| EP1219306A1 (en) * | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| ES2377318T3 (es) | 2002-09-06 | 2012-03-26 | Cerulean Pharma Inc. | Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos |
| RU2332425C2 (ru) * | 2002-09-06 | 2008-08-27 | Инсёрт Терапьютикс, Инк. | Полимеры на основе циклодекстрина для доставки терапевтических средств |
| KR20050051686A (ko) * | 2002-10-09 | 2005-06-01 | 인설트 테라페틱스, 인코퍼레이티드 | 사이클로덱스트린-기초한 재료, 조성물 및 이의 용도 |
| US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| CN102781237A (zh) * | 2009-11-23 | 2012-11-14 | 天蓝制药公司 | 用于传递治疗剂的基于环糊精的聚合物 |
| US20140094432A1 (en) | 2012-10-02 | 2014-04-03 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | 凍結乾燥方法 |
| CN113597532B (zh) | 2019-03-14 | 2023-02-17 | 泰尔茂比司特生物技术有限公司 | 冻干容器填充固定装置、系统及使用方法 |
| CN116249522A (zh) * | 2020-07-20 | 2023-06-09 | 深圳迈瑞生物医疗电子股份有限公司 | 一种组合物的血小板解聚用途、解聚试剂及解聚方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991014681A1 (en) * | 1990-03-28 | 1991-10-03 | Chinoin Gyógyszer És Vegyészeti Termékek Gyára Rt | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3780180A (en) | 1971-02-04 | 1973-12-18 | Sandoz Ag | N-substituted amino-n-nitroso-aminoace-tonitriles in the treatment of hypertension |
| US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5208233A (en) * | 1989-09-15 | 1993-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5212204A (en) * | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
| WO1993007114A1 (en) * | 1991-09-24 | 1993-04-15 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| US5389675A (en) * | 1992-03-27 | 1995-02-14 | The United States Of America As Represented By The Department Of Health And Human Services | Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents |
-
1994
- 1994-04-26 HU HU9401183A patent/HU218280B/hu not_active IP Right Cessation
-
1995
- 1995-04-25 BR BR9506155A patent/BR9506155A/pt not_active Application Discontinuation
- 1995-04-25 DK DK95918104T patent/DK0705255T3/da active
- 1995-04-25 AT AT95918104T patent/ATE197708T1/de active
- 1995-04-25 HR HRP9401183A patent/HRP950249A2/hr not_active Application Discontinuation
- 1995-04-25 CZ CZ953163A patent/CZ316395A3/cs unknown
- 1995-04-25 JP JP52720795A patent/JP3434828B2/ja not_active Expired - Lifetime
- 1995-04-25 CA CA002163539A patent/CA2163539C/en not_active Expired - Lifetime
- 1995-04-25 ES ES95918104T patent/ES2153897T3/es not_active Expired - Lifetime
- 1995-04-25 CN CN95190353A patent/CN1060164C/zh not_active Expired - Fee Related
- 1995-04-25 NZ NZ285149A patent/NZ285149A/en unknown
- 1995-04-25 MD MD95-0440A patent/MD1419G2/ro unknown
- 1995-04-25 RU RU96100760A patent/RU2136698C1/ru active
- 1995-04-25 PT PT95918104T patent/PT705255E/pt unknown
- 1995-04-25 PL PL95312183A patent/PL312183A1/xx unknown
- 1995-04-25 SI SI9530435T patent/SI0705255T1/xx unknown
- 1995-04-25 AU AU24159/95A patent/AU694219B2/en not_active Expired
- 1995-04-25 IL IL11349195A patent/IL113491A/en not_active IP Right Cessation
- 1995-04-25 RO RO95-02248A patent/RO114449B1/ro unknown
- 1995-04-25 YU YU25995A patent/YU25995A/sh unknown
- 1995-04-25 SK SK1551-95A patent/SK155195A3/sk unknown
- 1995-04-25 DE DE69519463T patent/DE69519463T2/de not_active Expired - Lifetime
- 1995-04-25 WO PCT/HU1995/000011 patent/WO1995029172A1/en not_active Ceased
- 1995-04-25 KR KR1019950705912A patent/KR960703404A/ko not_active Ceased
- 1995-04-25 EP EP95918104A patent/EP0705255B1/en not_active Expired - Lifetime
- 1995-04-25 US US08/571,853 patent/US5698535A/en not_active Expired - Fee Related
- 1995-12-20 FI FI956156A patent/FI956156A0/fi not_active Application Discontinuation
- 1995-12-22 LT LT95-133A patent/LT4167B/lt not_active IP Right Cessation
- 1995-12-22 LV LVP-95-383A patent/LV11543B/en unknown
- 1995-12-22 NO NO19955283A patent/NO311030B1/no not_active IP Right Cessation
-
1996
- 1996-01-26 BG BG100313A patent/BG61974B1/bg unknown
-
2001
- 2001-02-02 GR GR20010400181T patent/GR3035356T3/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991014681A1 (en) * | 1990-03-28 | 1991-10-03 | Chinoin Gyógyszer És Vegyészeti Termékek Gyára Rt | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD99 | Pending application |