MD1471F1 - Antibacterial and antifungal medicinal agent - Google Patents
Antibacterial and antifungal medicinal agent Download PDFInfo
- Publication number
- MD1471F1 MD1471F1 MD000026A MD000026A MD1471F1 MD 1471 F1 MD1471 F1 MD 1471F1 MD 000026 A MD000026 A MD 000026A MD 000026 A MD000026 A MD 000026A MD 1471 F1 MD1471 F1 MD 1471F1
- Authority
- MD
- Moldova
- Prior art keywords
- juglone
- hydroxyacid
- alcoholic solution
- polybasic
- polybasic organic
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- KQPYUDDGWXQXHS-UHFFFAOYSA-N juglone Chemical compound O=C1C=CC(=O)C2=C1C=CC=C2O KQPYUDDGWXQXHS-UHFFFAOYSA-N 0.000 abstract 6
- 150000001261 hydroxy acids Chemical class 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- VYTBDSUNRJYVHL-UHFFFAOYSA-N beta-Hydrojuglone Natural products O=C1CCC(=O)C2=C1C=CC=C2O VYTBDSUNRJYVHL-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the pharmaceutics, in particular to the stable agents with fungicidal and bactericidal action at the internal application thereof. Summary of the invention consists in the fact that the juglone (5-hydroxy-1,4-naphthoquinone) alcoholic solution additionally contains pharmaceutically acceptable polybasic organic hydroxyacids, for example, citric, malic or tartaric acid with the following component ratio, mass %: juglone 0,18...0,22 polybasic organic hydroxyacid 0,20...1,50 ethyl alcohol the rest. The presence of the polybasic hydroxyacid into the alcoholic solution in the indicated contents ensures a higher stability in storage (1,5...2,0 years) with the maintenance of the pharmacologic activity of the agent finished form, notwithstanding the water used for dilution, owing to the capacity of the given acids type to strongly complex with the alkali-earth metals ions present into the undistilled water. Claims: 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD000026A MD1471F1 (en) | 2000-01-14 | 2000-01-14 | Antibacterial and antifungal medicinal agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD000026A MD1471F1 (en) | 2000-01-14 | 2000-01-14 | Antibacterial and antifungal medicinal agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD1471F1 true MD1471F1 (en) | 2000-05-31 |
Family
ID=19738461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD000026A MD1471F1 (en) | 2000-01-14 | 2000-01-14 | Antibacterial and antifungal medicinal agent |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD1471F1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023142221A1 (en) * | 2022-01-26 | 2023-08-03 | 上海交通大学 | Disinfection product based on citric acid and natural naphthoquinone compound |
-
2000
- 2000-01-14 MD MD000026A patent/MD1471F1/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023142221A1 (en) * | 2022-01-26 | 2023-08-03 | 上海交通大学 | Disinfection product based on citric acid and natural naphthoquinone compound |
| CN116530515A (en) * | 2022-01-26 | 2023-08-04 | 上海交通大学 | Disinfection product based on citric acid and natural naphthoquinone compounds |
| CN116530515B (en) * | 2022-01-26 | 2025-08-19 | 上海交通大学 | Disinfection product based on citric acid and natural naphthoquinone compounds |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |