MD1861G2 - Derivaţi ai 6-arilpirido[2,3-d]pirimidinelor şi naftiridinelor, compoziţie farmaceutică pe baza lor, metode de tratament şi de inhibare a proliferării şi migraţiei celulei receptorului tirozinkinazei - Google Patents

Derivaţi ai 6-arilpirido[2,3-d]pirimidinelor şi naftiridinelor, compoziţie farmaceutică pe baza lor, metode de tratament şi de inhibare a proliferării şi migraţiei celulei receptorului tirozinkinazei Download PDF

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Publication number
MD1861G2
MD1861G2 MD97-0187A MD970187A MD1861G2 MD 1861 G2 MD1861 G2 MD 1861G2 MD 970187 A MD970187 A MD 970187A MD 1861 G2 MD1861 G2 MD 1861G2
Authority
MD
Moldova
Prior art keywords
inhibition
arylpyrido
naphthyridines
pyrimidines
migration
Prior art date
Application number
MD97-0187A
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English (en)
Russian (ru)
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MD1861F2 (ro
MD970187A (ro
Inventor
Клифтон Джон БЛЭНКЛЕЙ
Аннетт Мэриан ДОХЕРТИ
Джеймс Марино Хэмби
Роберт Ли ПАНЕК
Мел Конрад Шрёдер
Говард Дэниел Холлис ШОУОЛТЕР
Клео КОННОЛЛИ
Original Assignee
Уорнер-Ламберт Кампэни
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/539,410 external-priority patent/US5733913A/en
Application filed by Уорнер-Ламберт Кампэни filed Critical Уорнер-Ламберт Кампэни
Publication of MD970187A publication Critical patent/MD970187A/ro
Publication of MD1861F2 publication Critical patent/MD1861F2/ro
Publication of MD1861G2 publication Critical patent/MD1861G2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Invenţia se referă la chimie şi medicină, în particular la inhibarea proteinkinazei.Sunt revendicaţi derivaţii 6-arilpirido[2,3-d]pirimidinelor şi naftiri¬¬dinelor cu formula (I)în care X reprezintă CH sau N;B reprezintă halogen, hidroxil sau NR3 R4.De asemenea, sunt revendicate o compoziţie farmaceutică şi metode de tratament al ateros¬clerozei, res¬tenozei, psoriazisului, infecţiilor bacteriene şi de inhibare a proliferării şi migraţiei celulelor receptorilor tirozinkinazei.
MD97-0187A 1994-11-14 1995-11-13 Derivaţi ai 6-arilpirido[2,3-d]pirimidinelor şi naftiridinelor, compoziţie farmaceutică pe baza lor, metode de tratament şi de inhibare a proliferării şi migraţiei celulei receptorului tirozinkinazei MD1861G2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33905194A 1994-11-14 1994-11-14
US08/539,410 US5733913A (en) 1994-11-14 1995-11-06 6-Aryl pyrido 2,3-d! pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation
PCT/US1995/014700 WO1996015128A2 (en) 1994-11-14 1995-11-13 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION

Publications (3)

Publication Number Publication Date
MD970187A MD970187A (ro) 1999-02-28
MD1861F2 MD1861F2 (ro) 2002-02-28
MD1861G2 true MD1861G2 (ro) 2002-09-30

Family

ID=26991470

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0187A MD1861G2 (ro) 1994-11-14 1995-11-13 Derivaţi ai 6-arilpirido[2,3-d]pirimidinelor şi naftiridinelor, compoziţie farmaceutică pe baza lor, metode de tratament şi de inhibare a proliferării şi migraţiei celulei receptorului tirozinkinazei

Country Status (25)

Country Link
US (1) US5952342A (ro)
EP (1) EP0790997B1 (ro)
CN (1) CN1085666C (ro)
AT (1) ATE190978T1 (ro)
AU (1) AU711426B2 (ro)
BG (1) BG63162B1 (ro)
CZ (1) CZ286160B6 (ro)
DE (1) DE69515898T2 (ro)
DK (1) DK0790997T3 (ro)
ES (1) ES2146782T3 (ro)
FI (1) FI971953A7 (ro)
GE (1) GEP20012444B (ro)
GR (1) GR3033439T3 (ro)
HU (1) HUT76853A (ro)
IL (1) IL115970A (ro)
MD (1) MD1861G2 (ro)
MX (1) MX9702245A (ro)
NO (1) NO308250B1 (ro)
NZ (1) NZ296456A (ro)
PL (1) PL181893B1 (ro)
PT (1) PT790997E (ro)
RU (1) RU2191188C2 (ro)
SK (1) SK281724B6 (ro)
TJ (1) TJ342B (ro)
WO (1) WO1996015128A2 (ro)

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BG63162B1 (bg) 2001-05-31
RU2191188C2 (ru) 2002-10-20
DK0790997T3 (da) 2000-08-21
IL115970A0 (en) 1996-01-31
CZ139097A3 (cs) 1998-02-18
NO972198L (no) 1997-05-13
SK60997A3 (en) 1998-05-06
ATE190978T1 (de) 2000-04-15
AU711426B2 (en) 1999-10-14
WO1996015128A2 (en) 1996-05-23
DE69515898D1 (de) 2000-04-27
NO972198D0 (no) 1997-05-13
MD1861F2 (ro) 2002-02-28
MX9702245A (es) 1997-06-28
NZ296456A (en) 1999-09-29
CN1169726A (zh) 1998-01-07
CN1085666C (zh) 2002-05-29
EP0790997A2 (en) 1997-08-27
PL320169A1 (en) 1997-09-15
WO1996015128A3 (en) 1996-07-11
IL115970A (en) 1999-06-20
CZ286160B6 (cs) 2000-01-12
MD970187A (ro) 1999-02-28
DE69515898T2 (de) 2000-08-17
EP0790997B1 (en) 2000-03-22
US5952342A (en) 1999-09-14
AU4107896A (en) 1996-06-06
NO308250B1 (no) 2000-08-21
BG101326A (bg) 1998-04-30
FI971953A0 (fi) 1997-05-07
HUT76853A (en) 1997-12-29
FI971953L (fi) 1997-05-12
PL181893B1 (pl) 2001-10-31
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SK281724B6 (sk) 2001-07-10

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