MD20140101A2 - Utilizarea concomitentă a unui inhibitor al clusterinei cu un inhibitor al EGFR pentru tratamentul cancerului - Google Patents
Utilizarea concomitentă a unui inhibitor al clusterinei cu un inhibitor al EGFR pentru tratamentul cancerului Download PDFInfo
- Publication number
- MD20140101A2 MD20140101A2 MDA20140101A MD20140101A MD20140101A2 MD 20140101 A2 MD20140101 A2 MD 20140101A2 MD A20140101 A MDA20140101 A MD A20140101A MD 20140101 A MD20140101 A MD 20140101A MD 20140101 A2 MD20140101 A2 MD 20140101A2
- Authority
- MD
- Moldova
- Prior art keywords
- clusterin
- inhibitor
- egfr
- cancer
- cancer cells
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 7
- 201000011510 cancer Diseases 0.000 title abstract 7
- 229940086740 Clusterin inhibitor Drugs 0.000 title abstract 2
- 229940121647 egfr inhibitor Drugs 0.000 title abstract 2
- 102000001301 EGF receptor Human genes 0.000 abstract 3
- 108060006698 EGF receptor Proteins 0.000 abstract 3
- 102000000905 Cadherin Human genes 0.000 abstract 1
- 108050007957 Cadherin Proteins 0.000 abstract 1
- 102000003780 Clusterin Human genes 0.000 abstract 1
- 108090000197 Clusterin Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Invenţia se referă la medicină, în special la oncologie, şi poate fi utilizată pentru tratamentul cancerului.Conform invenţiei, expresia receptorului factorului de creştere epidermică (EGFR) şi fosforilarea se intensifică în celulele canceroase tratate cu anticorpi anti-clusterină. Un astfel de tratament este de asemenea însoţit de reapariţia unui fenotip epitelial al celulelor canceroase, aşa cum este ilustrat printr-o expresie crescută a E-caderinei la suprafaţa celulelor canceroase. Inhibitorii clusterinei pot astfel induce inversarea fenotipului epitelial în cel mezenchimal şi restabili sensibilitatea celulelor canceroase faţă de inhibitorii EGFR. Astfel, în prezenta invenţie sunt oferite combinaţii dintre un inhibitor al clusterinei şi un inhibitor EGFR, precum şi utilizarea acestora pentru tratamentul cancerului.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361601786P | 2013-02-22 | 2013-02-22 | |
| PCT/CA2013/000167 WO2013123588A1 (en) | 2012-02-22 | 2013-02-22 | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD20140101A2 true MD20140101A2 (ro) | 2015-02-28 |
Family
ID=52580519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20140101A MD20140101A2 (ro) | 2013-02-22 | 2013-02-22 | Utilizarea concomitentă a unui inhibitor al clusterinei cu un inhibitor al EGFR pentru tratamentul cancerului |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD20140101A2 (ro) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006056054A1 (en) * | 2004-11-23 | 2006-06-01 | The University Of British Columbia | Treatment of cancer with a combination of an agent that perturbs the egf signaling pathway and an oligonucleotide that reduces clusterin levels |
| WO2007030930A1 (en) * | 2005-09-13 | 2007-03-22 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
-
2013
- 2013-02-22 MD MDA20140101A patent/MD20140101A2/ro not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006056054A1 (en) * | 2004-11-23 | 2006-06-01 | The University Of British Columbia | Treatment of cancer with a combination of an agent that perturbs the egf signaling pathway and an oligonucleotide that reduces clusterin levels |
| WO2007030930A1 (en) * | 2005-09-13 | 2007-03-22 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC9A | Refusal of application (patent for invention) |