MD20170094A2 - Procedeu de fabricare a amestecurilor de pulbere uscată - Google Patents

Procedeu de fabricare a amestecurilor de pulbere uscată Download PDF

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Publication number
MD20170094A2
MD20170094A2 MDA20170094A MD20170094A MD20170094A2 MD 20170094 A2 MD20170094 A2 MD 20170094A2 MD A20170094 A MDA20170094 A MD A20170094A MD 20170094 A MD20170094 A MD 20170094A MD 20170094 A2 MD20170094 A2 MD 20170094A2
Authority
MD
Moldova
Prior art keywords
dry powder
micronized
powder blends
manufacturing dry
excipient
Prior art date
Application number
MDA20170094A
Other languages
English (en)
Russian (ru)
Inventor
Абхишек Гупта
Герберт Кларк ЧОУ
Самиран Де
Францискус Коппенхаген
Сянь-Мин Цзэн
Original Assignee
Lupin Atlantis Holdings Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Atlantis Holdings Sa filed Critical Lupin Atlantis Holdings Sa
Publication of MD20170094A2 publication Critical patent/MD20170094A2/ro

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia se referă la procedee de amestecare a pulberii uscate a particulelor solide farmaceutice şi non-farmaceutice. În particular, invenţia se referă la un procedeu de preparare a unui amestec uscat de pulbere de microparticule, care include unul sau mai multe ingrediente farmaceutice active micronizate (IFA) şi, opţional, unul sau mai mulţi purtători acceptabili farmaceutic micronizaţi sau nemicronizatţi şi/sau excipienţi, în care procedeul include etapele de „amestecare pulsatorie” a ingredientului(elor) farmaceutic(e) activ(e) micronizat(e) şi a purtătorului(ilor) şi/sau a excipientului(ţilor) acceptabil(i) farmaceutic.
MDA20170094A 2015-04-01 2016-04-01 Procedeu de fabricare a amestecurilor de pulbere uscată MD20170094A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN380KO2015 2015-04-01
PCT/IB2016/000418 WO2016156970A1 (en) 2015-04-01 2016-04-01 Process for manufacturing dry powder blends

Publications (1)

Publication Number Publication Date
MD20170094A2 true MD20170094A2 (ro) 2018-04-30

Family

ID=56024334

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20170094A MD20170094A2 (ro) 2015-04-01 2016-04-01 Procedeu de fabricare a amestecurilor de pulbere uscată

Country Status (14)

Country Link
US (1) US10617646B2 (ro)
EP (1) EP3277265A1 (ro)
CN (1) CN107864622A (ro)
AU (1) AU2016241369A1 (ro)
BR (1) BR112017021111A2 (ro)
CA (1) CA2981440A1 (ro)
CL (1) CL2017002470A1 (ro)
CO (1) CO2017011220A2 (ro)
EA (1) EA201792159A1 (ro)
IL (1) IL254814A0 (ro)
MA (1) MA41855A (ro)
MD (1) MD20170094A2 (ro)
MX (1) MX2017012633A (ro)
WO (1) WO2016156970A1 (ro)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019067708A1 (en) * 2017-09-27 2019-04-04 Teva Branded Pharmaceutical Products R&D, Inc. METHOD FOR DECREASING PARTICLE SIZE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324897D0 (en) 2003-10-24 2003-11-26 Glaxo Group Ltd Composition
US20110105449A1 (en) * 2007-11-07 2011-05-05 Astrazeneca R&D Dry powder formulations comprising ascorbic acid derivates
WO2013091006A1 (en) 2011-12-23 2013-06-27 Monash University Process for dry powder blending
GB201205632D0 (en) 2012-03-30 2012-05-16 Vectura Ltd Method and apparatus
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis

Also Published As

Publication number Publication date
CO2017011220A2 (es) 2018-01-16
WO2016156970A1 (en) 2016-10-06
EP3277265A1 (en) 2018-02-07
IL254814A0 (en) 2017-12-31
US10617646B2 (en) 2020-04-14
EA201792159A1 (ru) 2018-01-31
BR112017021111A2 (pt) 2018-07-03
AU2016241369A1 (en) 2017-11-02
MX2017012633A (es) 2018-06-20
CA2981440A1 (en) 2016-10-06
US20180071218A1 (en) 2018-03-15
CL2017002470A1 (es) 2018-04-13
CN107864622A (zh) 2018-03-30
MA41855A (fr) 2021-03-31

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Legal Events

Date Code Title Description
FA9A Abandonment or withdrawal of application (patent for invention)