MD20200027A2 - Utilizarea derivatului de glutaramidă pentru tratarea afecţiunilor, asociate cu activitatea aberantă a citokinelor - Google Patents
Utilizarea derivatului de glutaramidă pentru tratarea afecţiunilor, asociate cu activitatea aberantă a citokinelor Download PDFInfo
- Publication number
- MD20200027A2 MD20200027A2 MDA20200027A MD20200027A MD20200027A2 MD 20200027 A2 MD20200027 A2 MD 20200027A2 MD A20200027 A MDA20200027 A MD A20200027A MD 20200027 A MD20200027 A MD 20200027A MD 20200027 A2 MD20200027 A2 MD 20200027A2
- Authority
- MD
- Moldova
- Prior art keywords
- treatment
- diseases associated
- compound
- pharmaceutically acceptable
- well
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la medicină, în particular, la terapia afecţiunilor, asociate cu activitatea aberantă a fractalkinei şi a proteinelor chemoatractante monocitare 1-4 (CCL2, CCL7, CCL8, CCL13), preponderent, la terapia sindromului algic, febrei, pneumoniei, bronşitei, bronşiolitei, alveolitei, artritei reumatoide şi psoriazisului, precum şi altor boli, utilizând compusul 1-(2-(1H-imidazol-4-il)etil)piperidin-2,6-dioneisau sarea acceptabilă farmaceutic sau solvatul acestuia.Prezenta invenţie se referă, de asemenea, la compoziţii farmaceutice, care conţin o cantitate eficientă terapeutic de compus, conform invenţiei. Compusul dat, precum şi sărurile sale acceptabile farmaceutic, posedă o eficienţă înaltă în inhibarea activităţii enzimei glutaminilciclază, implicate, în particular, în procesele de modificare post-translaţională a citokinelor menţionate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2017131435 | 2017-09-07 | ||
| PCT/RU2018/000135 WO2019050429A1 (ru) | 2017-09-07 | 2018-03-06 | Применение производного глутаримида для лечения заболеваний, связанных с аберрантной активностью цитокинов |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20200027A2 true MD20200027A2 (ro) | 2020-09-30 |
| MD4788B1 MD4788B1 (ro) | 2022-02-28 |
| MD4788C1 MD4788C1 (ro) | 2022-09-30 |
Family
ID=65634221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20210031A MD4802C1 (ro) | 2017-09-07 | 2018-03-06 | Utilizarea derivatului de glutaramidă pentru tratarea afecţiunilor, asociate cu activitatea aberantă a citokinelor |
| MDA20200027A MD4788C1 (ro) | 2017-09-07 | 2018-03-06 | Utilizarea derivatului de glutarimidă pentru tratarea afecţiunilor, legate de activitatea aberantă a citokinelor |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20210031A MD4802C1 (ro) | 2017-09-07 | 2018-03-06 | Utilizarea derivatului de glutaramidă pentru tratarea afecţiunilor, asociate cu activitatea aberantă a citokinelor |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11439631B2 (ro) |
| CN (1) | CN111093661B (ro) |
| CL (1) | CL2020000554A1 (ro) |
| EA (2) | EA039391B1 (ro) |
| GE (4) | GEP20227402B (ro) |
| MD (2) | MD4802C1 (ro) |
| MY (1) | MY197850A (ro) |
| PH (1) | PH12020500462A1 (ro) |
| WO (1) | WO2019050429A1 (ro) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2712281C1 (ru) * | 2018-11-23 | 2020-01-28 | Общество С Ограниченной Ответственностью "Хемиммьюн Терапьютикс" | Применение производного глутаримида для преодоления резистентности к стероидам и терапии заболеваний, ассоциированных с аберрантным сигналингом интерферона гамма |
| WO2021262040A1 (ru) * | 2020-06-26 | 2021-12-30 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение производного глутаримида для терапии заболеваний, ассоциированных с аберрантной активностью интерлейкина-6 |
| WO2023177329A1 (ru) * | 2022-03-18 | 2023-09-21 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9524157D0 (en) * | 1995-11-25 | 1996-01-24 | Pfizer Ltd | Therapeutic agents |
| DE10002509A1 (de) | 2000-01-21 | 2001-07-26 | Gruenenthal Gmbh | Substituierte Glutarimide |
| MX2007016290A (es) * | 2005-06-30 | 2008-03-10 | Celgene Corp | Procesos para la preparacion de compuestos de 4-amino-2(2,6-dioxopiperidin-3-il)isoindolin-1,3-diona. |
| GB201009603D0 (en) * | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| CN110128406B (zh) * | 2013-04-12 | 2021-08-27 | 制药有限责任公司 | 戊二酰亚胺衍生物、其用途、基于所述衍生物的药物组合物及戊二酰亚胺衍生物的制备方法 |
| RU2552929C1 (ru) | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
| US20160046898A1 (en) * | 2014-08-12 | 2016-02-18 | Pbs Biotech, Inc. | Cell growth macrocarriers for bioreactors |
-
2018
- 2018-03-06 GE GEAP201815309A patent/GEP20227402B/en unknown
- 2018-03-06 US US16/644,899 patent/US11439631B2/en active Active
- 2018-03-06 GE GEAP202215309A patent/GEAP202215309A/en unknown
- 2018-03-06 EA EA201992337A patent/EA039391B1/ru unknown
- 2018-03-06 MD MDA20210031A patent/MD4802C1/ro active IP Right Grant
- 2018-03-06 MD MDA20200027A patent/MD4788C1/ro active IP Right Revival
- 2018-03-06 GE GEAP201815467A patent/GEP20227354B/en unknown
- 2018-03-06 EA EA201992341A patent/EA201992341A8/ru unknown
- 2018-03-06 MY MYPI2020001186A patent/MY197850A/en unknown
- 2018-03-06 CN CN201880057736.9A patent/CN111093661B/zh not_active Expired - Fee Related
- 2018-03-06 WO PCT/RU2018/000135 patent/WO2019050429A1/ru not_active Ceased
- 2018-03-06 GE GEAP202115467A patent/GEAP202115467A/en unknown
-
2020
- 2020-03-05 CL CL2020000554A patent/CL2020000554A1/es unknown
- 2020-03-06 PH PH12020500462A patent/PH12020500462A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MD4802C1 (ro) | 2022-11-30 |
| MD4788C1 (ro) | 2022-09-30 |
| WO2019050429A1 (ru) | 2019-03-14 |
| GEAP202215309A (en) | 2022-04-11 |
| CN111093661A (zh) | 2020-05-01 |
| EA201992341A8 (ru) | 2020-08-11 |
| CL2020000554A1 (es) | 2020-10-23 |
| US11439631B2 (en) | 2022-09-13 |
| EA039391B1 (ru) | 2022-01-21 |
| MY197850A (en) | 2023-07-20 |
| GEP20227402B (en) | 2022-08-10 |
| GEP20227354B (en) | 2022-02-25 |
| US20200188379A1 (en) | 2020-06-18 |
| MD20210031A2 (ro) | 2021-10-31 |
| CN111093661B (zh) | 2023-10-27 |
| MD4802B1 (ro) | 2022-04-30 |
| PH12020500462A1 (en) | 2021-01-11 |
| EA201992341A1 (ru) | 2020-02-28 |
| GEAP202115467A (en) | 2021-10-11 |
| EA201992337A1 (ru) | 2020-02-13 |
| MD4788B1 (ro) | 2022-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD4A | Change of proprietorship (patent for invention) |
Owner name: LTD VALENTA-INTELLEKT, RU UL. RYABINOVAYA, D. 26 BUILDING 10, CAB. 6-26, MOSCOW, 121471, FEDERATIA RUSA;IP NEBOLSIN VLADIMIR EVGHENIEVICH, RU STR. GOLITSYNSKAYA, 457, ISTRINSKIY R-N, D. BORZYE, MOSKOVSKAYA OBL., 143581, FEDERATIA RUSA Free format text: PREVIOUS PROPRIETOR: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES",RU 121205, MOSCOW, MOZHAISKY MUNICIPAL DISTRICT, TERRITORY OF THE SKOLKOVO INNOVATION CENTER, BOLSHOY BOULEVARD, HOUSE 42, BUILDING 1, FLOOR 3, ROOM 1280, FEDERATIA RUSA |
|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| NF4A | Restoration of lapsed patent for invention |