MD3655G2 - Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper - Google Patents

Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper Download PDF

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Publication number
MD3655G2
MD3655G2 MDA20070238A MD20070238A MD3655G2 MD 3655 G2 MD3655 G2 MD 3655G2 MD A20070238 A MDA20070238 A MD A20070238A MD 20070238 A MD20070238 A MD 20070238A MD 3655 G2 MD3655 G2 MD 3655G2
Authority
MD
Moldova
Prior art keywords
myeloid leukemia
thiosemicarbazonato
tridecane
tricyclo
inhibitor
Prior art date
Application number
MDA20070238A
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Romanian (ro)
Russian (ru)
Other versions
MD3655F1 (en
Inventor
Аурелиан ГУЛЯ
Тудор РОШУ
Алена КОТОВАЯ
Пойриер ДОНАЛД
Рой ДЖЕННИ
Виктор ЦАПКОВ
Original Assignee
Государственный Университет Молд0
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Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20070238A priority Critical patent/MD3655G2/en
Publication of MD3655F1 publication Critical patent/MD3655F1/en
Publication of MD3655G2 publication Critical patent/MD3655G2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to chemistry, namely to the synthesis of a coordinative compound from the class of thiosemicarbazonates of transition metals and can be applied in medicine for prophylaxis and treatment of myeloid leukemia.Summary of the invention consists in that as inhibitor of human myeloid leukemia is proposed bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper of formula:
MDA20070238A 2007-09-03 2007-09-03 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper MD3655G2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20070238A MD3655G2 (en) 2007-09-03 2007-09-03 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20070238A MD3655G2 (en) 2007-09-03 2007-09-03 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper

Publications (2)

Publication Number Publication Date
MD3655F1 MD3655F1 (en) 2008-07-31
MD3655G2 true MD3655G2 (en) 2009-02-28

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MDA20070238A MD3655G2 (en) 2007-09-03 2007-09-03 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides
MD3995C2 (en) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation
MD4132C1 (en) * 2010-12-13 2012-05-31 Государственный Университет Молд0 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells
MD20110040A1 (en) * 2011-05-10 2012-11-30 Государственный Университет Молд0 Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate
MD4190C1 (en) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper}
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4393C1 (en) * 2015-09-04 2016-08-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper
MD4407C1 (en) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3098G2 (en) * 2006-01-03 2007-02-28 Государственный Университет Молд0 Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3098G2 (en) * 2006-01-03 2007-02-28 Государственный Университет Молд0 Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides
MD3995C2 (en) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation
MD4132C1 (en) * 2010-12-13 2012-05-31 Государственный Университет Молд0 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells
MD20110040A1 (en) * 2011-05-10 2012-11-30 Государственный Университет Молд0 Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate
MD4190C1 (en) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper}
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4407C1 (en) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate
MD4393C1 (en) * 2015-09-04 2016-08-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper

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Publication number Publication date
MD3655F1 (en) 2008-07-31

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees