MD4346818T2 - Forme solide de dozare și regimuri de dozare care cuprind (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-metoxi-fenil)-4,5-dimetil-5-(trifluorometil)tetrahidrofuran- 2-carbonil]amino]piridin-2-carboxamidă - Google Patents

Forme solide de dozare și regimuri de dozare care cuprind (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-metoxi-fenil)-4,5-dimetil-5-(trifluorometil)tetrahidrofuran- 2-carbonil]amino]piridin-2-carboxamidă

Info

Publication number
MD4346818T2
MD4346818T2 MDE20240382T MDE20240382T MD4346818T2 MD 4346818 T2 MD4346818 T2 MD 4346818T2 MD E20240382 T MDE20240382 T MD E20240382T MD E20240382 T MDE20240382 T MD E20240382T MD 4346818 T2 MD4346818 T2 MD 4346818T2
Authority
MD
Moldova
Prior art keywords
difluoro
carboxamide
trifluoromethyl
carbonyl
pyridine
Prior art date
Application number
MDE20240382T
Other languages
English (en)
Inventor
Radhika Karkare
Cathy Chu
Brenda Cirincione
Darin J Correll
Philip Kaj Harder Delff
Kirk Raymond Dinehart
Gallo Paloma Benito
Tanya Louise Hay
Licong Jiang
James B Jones
Katie L Mccarty
Catherine P Metzler
Jonathan M Miller
Mark C Peterson
Rahul Roopwani
John F Staropoli
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MD4346818T2 publication Critical patent/MD4346818T2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Este prezentată o dispersie solidă de (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-metoxi-fenil)-4,5-dimetil-5-(trifluorometil) tetrahidrofuran-2-carbonil]amino]piridin-2-carboxamidă (Compusul 1), definită aşa cum este descrisă aici, sau o sare farmaceutic acceptabilă a acesteia şi o tabletă care conţine dispersia solidă pentru tratarea durerii. De asemenea, este descris aici Compusul 1 sau o sare farmaceutic acceptabilă a acestuia pentru utilizare într-o metodă de tratare a durerii.
MDE20240382T 2021-06-04 2022-06-03 Forme solide de dozare și regimuri de dozare care cuprind (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-metoxi-fenil)-4,5-dimetil-5-(trifluorometil)tetrahidrofuran- 2-carbonil]amino]piridin-2-carboxamidă MD4346818T2 (ro)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163196937P 2021-06-04 2021-06-04
US202163196933P 2021-06-04 2021-06-04
US202163285197P 2021-12-02 2021-12-02
US202163285201P 2021-12-02 2021-12-02
PCT/US2022/032253 WO2022256708A1 (en) 2021-06-04 2022-06-03 Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide

Publications (1)

Publication Number Publication Date
MD4346818T2 true MD4346818T2 (ro) 2026-03-31

Family

ID=82492526

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20240382T MD4346818T2 (ro) 2021-06-04 2022-06-03 Forme solide de dozare și regimuri de dozare care cuprind (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-metoxi-fenil)-4,5-dimetil-5-(trifluorometil)tetrahidrofuran- 2-carbonil]amino]piridin-2-carboxamidă

Country Status (23)

Country Link
US (1) US20240285596A1 (ro)
EP (2) EP4346818B1 (ro)
JP (1) JP2024520649A (ro)
KR (1) KR20240031299A (ro)
AU (1) AU2022284952A1 (ro)
BR (1) BR112023025264A2 (ro)
CA (1) CA3222197A1 (ro)
DK (1) DK4346818T3 (ro)
ES (1) ES3063352T3 (ro)
FI (1) FI4346818T3 (ro)
HR (1) HRP20260068T1 (ro)
IL (1) IL308954A (ro)
LT (1) LT4346818T (ro)
MA (1) MA64856B1 (ro)
MD (1) MD4346818T2 (ro)
MX (1) MX2023014376A (ro)
PL (1) PL4346818T3 (ro)
PT (1) PT4346818T (ro)
RS (1) RS67745B1 (ro)
SI (1) SI4346818T1 (ro)
SM (1) SMT202600064T1 (ro)
TW (1) TW202317108A (ro)
WO (1) WO2022256708A1 (ro)

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EP4346818B1 (en) 2025-12-03
IL308954A (en) 2024-01-01
KR20240031299A (ko) 2024-03-07
MA64856B1 (fr) 2026-02-27
DK4346818T3 (da) 2026-02-02
AU2022284952A1 (en) 2023-12-14
ES3063352T3 (en) 2026-04-16
HRP20260068T1 (hr) 2026-02-27
SI4346818T1 (sl) 2026-03-31
LT4346818T (lt) 2026-03-25
FI4346818T3 (fi) 2026-02-05
TW202317108A (zh) 2023-05-01
SMT202600064T1 (it) 2026-03-09
JP2024520649A (ja) 2024-05-24
EP4346818A1 (en) 2024-04-10
PT4346818T (pt) 2026-02-17
EP4714435A2 (en) 2026-03-25
BR112023025264A2 (pt) 2024-02-20
RS67745B1 (sr) 2026-03-31
US20240285596A1 (en) 2024-08-29
CA3222197A1 (en) 2022-12-08
MX2023014376A (es) 2024-03-04
PL4346818T3 (pl) 2026-03-23
WO2022256708A1 (en) 2022-12-08

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