MD4760B1 - Compoziţii şi metode de tratament al infecţiilor provocate de viruşii hepatitei B şi hepatitei D - Google Patents

Compoziţii şi metode de tratament al infecţiilor provocate de viruşii hepatitei B şi hepatitei D Download PDF

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Publication number
MD4760B1
MD4760B1 MDA20170014A MD20170014A MD4760B1 MD 4760 B1 MD4760 B1 MD 4760B1 MD A20170014 A MDA20170014 A MD A20170014A MD 20170014 A MD20170014 A MD 20170014A MD 4760 B1 MD4760 B1 MD 4760B1
Authority
MD
Moldova
Prior art keywords
hepatitis
virus
compositions
treatment
methods
Prior art date
Application number
MDA20170014A
Other languages
English (en)
Russian (ru)
Other versions
MD4760C8 (ro
MD20170014A2 (ro
Inventor
Эндрю Вайан
Original Assignee
Replicor Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55063440&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4760(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Replicor Inc. filed Critical Replicor Inc.
Publication of MD20170014A2 publication Critical patent/MD20170014A2/ro
Publication of MD4760B1 publication Critical patent/MD4760B1/ro
Publication of MD4760C8 publication Critical patent/MD4760C8/ro

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Invenţia se referă la compoziţii şi metode de tratament al infecţiilor provocate de virusul hepatitei B sau de co-infecţia cu virusul hepatitei B şi virusul hepatitei D, care includ administrarea unui subiect ce are nevoie de un astfel de tratament al unui prim agent farmaceutic acceptabil, care conţine un complex chelat al cel puţin unui polimer al acidului nucleic tiofosfat şi al doilea agent farmaceutic acceptabil, care conţine cel puţin un analog nucleozidic/nucleotidic, care inhibă polimerazele HVB.Secvenţe: 20
MDA20170014A 2014-07-10 2015-07-07 Compoziţii şi metode de tratament al infecţiilor provocate de viruşii hepatitei B şi hepatitei D MD4760C8 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022846P 2014-07-10 2014-07-10
US201462091943P 2014-12-15 2014-12-15
PCT/CA2015/050626 WO2016004525A1 (en) 2014-07-10 2015-07-07 Methods for the treatment of hepatitis b and hepatitis d virus infections

Publications (3)

Publication Number Publication Date
MD20170014A2 MD20170014A2 (ro) 2017-07-31
MD4760B1 true MD4760B1 (ro) 2021-07-31
MD4760C8 MD4760C8 (ro) 2022-02-28

Family

ID=55063440

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20170014A MD4760C8 (ro) 2014-07-10 2015-07-07 Compoziţii şi metode de tratament al infecţiilor provocate de viruşii hepatitei B şi hepatitei D

Country Status (34)

Country Link
US (1) US9603865B2 (ro)
EP (1) EP3166615B1 (ro)
JP (2) JP2017521433A (ro)
KR (2) KR20170029577A (ro)
CN (2) CN113750112A (ro)
AU (1) AU2015286199B2 (ro)
BR (1) BR112017000320B1 (ro)
CA (1) CA2954182C (ro)
CL (1) CL2017000008A1 (ro)
CU (1) CU20170001A7 (ro)
CY (1) CY1126361T1 (ro)
DK (1) DK3166615T3 (ro)
DO (1) DOP2017000002A (ro)
EA (1) EA036745B1 (ro)
EC (1) ECSP16097355A (ro)
ES (1) ES2963814T3 (ro)
FI (1) FI3166615T3 (ro)
HK (1) HK1231402A1 (ro)
HR (1) HRP20231400T1 (ro)
HU (1) HUE064449T2 (ro)
IL (1) IL249660B (ro)
LT (1) LT3166615T (ro)
MD (1) MD4760C8 (ro)
MX (1) MX381042B (ro)
MY (1) MY178087A (ro)
PH (1) PH12017500010B1 (ro)
PL (1) PL3166615T3 (ro)
PT (1) PT3166615T (ro)
RS (1) RS64833B1 (ro)
SG (1) SG11201700073PA (ro)
SI (1) SI3166615T1 (ro)
SM (1) SMT202300380T1 (ro)
TW (1) TWI766831B (ro)
WO (1) WO2016004525A1 (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
US20200147124A1 (en) * 2018-11-08 2020-05-14 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
WO2021119325A1 (en) * 2019-12-12 2021-06-17 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
WO2021223398A1 (zh) * 2020-05-07 2021-11-11 西安新通药物研究股份有限公司 治疗肝病的晶型及其应用
CN113651853A (zh) * 2020-05-07 2021-11-16 西安新通药物研究股份有限公司 甲磺酸帕拉德福韦c晶型及其应用
CN114057816B (zh) * 2020-07-30 2025-02-11 浙江柏拉阿图医药科技有限公司 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用
WO2022109129A1 (en) * 2020-11-20 2022-05-27 Aligos Therapeutics, Inc. Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2022152869A1 (en) 2021-01-15 2022-07-21 Janssen Sciences Ireland Unlimited Company Use of oligonucleotides for individuals with hepatic impairment
WO2022261046A1 (en) * 2021-06-07 2022-12-15 Antios Therapeutics, Inc. Compositions and methods of treating hepatitis d and hepatitis b/hepatitis d co-infections with phosphoramidate clevudine prodrugs
CN117616121A (zh) 2021-07-09 2024-02-27 葛兰素史密斯克莱知识产权(第3号)有限公司 寡核苷酸用于具有肾脏损伤的个体的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482836A (en) * 1993-01-14 1996-01-09 The Regents Of The University Of California DNA purification by triplex-affinity capture and affinity capture electrophoresis
EA008940B1 (ru) 2002-09-13 2007-10-26 Репликор, Инк. Антивирусные олигонуклеотиды, не связанные с комплементарностью последовательностей
US9474793B2 (en) * 2005-02-22 2016-10-25 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Vaccines and methods for prevention and treatment of drug-resistant HIV-1 and hepatitis B virus
JP5775581B2 (ja) 2010-08-20 2015-09-09 レプリコール インコーポレーティッド オリゴヌクレオチドキレート錯体
WO2012058210A1 (en) * 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012075114A2 (en) * 2010-12-01 2012-06-07 Ablitech, Inc. Nucleic acid-polymer conjugates and uses thereof
AR091065A1 (es) * 2012-05-18 2014-12-30 Replicor Inc Una formulacion farmaceutica que comprende un quelato de oligonucleotidos antiviral para el tratamiento de una infeccion antiviral
HUE054875T2 (hu) * 2012-05-18 2021-10-28 Replicor Inc Oligonukleotid kelátkomplex-polipeptid készítmények és eljárások
CN104837501B (zh) * 2012-08-30 2018-11-02 里普利科股份有限公司 治疗乙型肝炎及丁型肝炎感染的方法

Also Published As

Publication number Publication date
US9603865B2 (en) 2017-03-28
HRP20231400T1 (hr) 2024-02-16
KR20230070330A (ko) 2023-05-22
AU2015286199B2 (en) 2020-05-14
CA2954182C (en) 2023-08-15
MX2017000053A (es) 2017-05-01
EP3166615A1 (en) 2017-05-17
JP6922030B2 (ja) 2021-08-18
ECSP16097355A (es) 2017-03-31
HUE064449T2 (hu) 2024-03-28
WO2016004525A1 (en) 2016-01-14
KR20170029577A (ko) 2017-03-15
IL249660A0 (en) 2017-02-28
US20160008393A1 (en) 2016-01-14
CU20170001A7 (es) 2017-04-05
IL249660B (en) 2022-02-01
MD4760C8 (ro) 2022-02-28
MX381042B (es) 2025-03-12
CA2954182A1 (en) 2016-01-14
PH12017500010B1 (en) 2022-07-29
PH12017500010A1 (en) 2017-05-15
CL2017000008A1 (es) 2017-06-09
EP3166615A4 (en) 2018-01-17
BR112017000320A2 (pt) 2017-11-07
ES2963814T3 (es) 2024-04-02
KR102734495B1 (ko) 2024-11-25
AU2015286199A1 (en) 2017-02-23
EP3166615B1 (en) 2023-08-09
TWI766831B (zh) 2022-06-11
PL3166615T3 (pl) 2024-02-19
FI3166615T3 (fi) 2023-11-06
CY1126361T1 (el) 2026-02-25
JP2020143065A (ja) 2020-09-10
RS64833B1 (sr) 2023-12-29
CN106659730A (zh) 2017-05-10
MY178087A (en) 2020-10-02
SI3166615T1 (sl) 2023-12-29
LT3166615T (lt) 2024-01-25
SG11201700073PA (en) 2017-02-27
HK1231402A1 (zh) 2017-12-22
TW201613617A (en) 2016-04-16
DOP2017000002A (es) 2017-03-15
SMT202300380T1 (it) 2024-01-10
EA036745B1 (ru) 2020-12-16
MD20170014A2 (ro) 2017-07-31
BR112017000320B1 (pt) 2023-02-07
NZ727583A (en) 2024-08-30
DK3166615T3 (da) 2023-11-13
PT3166615T (pt) 2023-11-13
CN113750112A (zh) 2021-12-07
EA201790160A1 (ru) 2017-06-30
JP2017521433A (ja) 2017-08-03

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