MD663G2 - Derivatives of erythromycin, methods for their preparation and use as medicines - Google Patents

Derivatives of erythromycin, methods for their preparation and use as medicines

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
compounds
heteroatoms
formula
saturated
possibly
Prior art date
Application number
MD95-0431A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD663F1 (en
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/en
Publication of MD663G2 publication Critical patent/MD663G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compuşii cu formula generală (I):în care fie că R1 şi R2, care sunt identici sau diferiţi, reprezintă atom de hidrogen sau radical de hidrocarbură, saturat sau nesaturat, conţinând până la 24 atomi de carbon, fiind eventual întrerupt prin unul sau mai mulţi heteroatomi şi având una sau mai multe grupări funcţionale; fie că R1 şi R2, împreună cu atomul de azot, cuplat cu ei, formează un inel heterociclic, ce conţine eventual unul sau mai mulţi heteroatomi, selectaţi dintre azot, oxigen sau sulf; fie că R1 şi R2, luaţi împreună, formează un radical (a), în care R'1 şi R'2, care sunt identici sau diferiţi, reprezintă atom de hidrogen sau radical de hidrocarbură, saturat sau nesaturat, conţinând până la 23 atomi de carbon, fiind eventual întrerupt prin unul sau mai mulţi heteroatomi şi conţinând una sau mai multe grupări funcţionale, şi Z reprezintă un atom de hidrogen sau un rest de acid carboxilic, conţinând până la 18 atomi de carbon, precum şi sărurile lor aditive cu acizii compuşilor cu formula (I). Compuşii cu formula (I) posedă proprietăţi antibiotice valoroase.Compounds of general formula (I): wherein either R 1 and R 2, which are the same or different, represent a saturated or unsaturated hydrogen or hydrocarbon radical containing up to 24 carbon atoms, possibly interrupted by one or more many heteroatoms and having one or more functional groups; or that R 1 and R 2, together with the nitrogen atom, coupled thereto, form a heterocyclic ring, possibly containing one or more heteroatoms, selected from nitrogen, oxygen or sulfur; either R 1 and R 2, taken together, form a radical (a), wherein R 1 and R 2, which are the same or different, represent a saturated or unsaturated hydrogen atom or hydrocarbon radical containing up to 23 atoms. of carbon, possibly interrupted by one or more heteroatoms and containing one or more functional groups, and Z represents a hydrogen atom or a carboxylic acid moiety, containing up to 18 carbon atoms, as well as their additive salts with acids. of compounds of formula (I). The compounds of formula (I) possess valuable antibiotic properties.

MD95-0431A 1994-04-08 1995-04-06 Derivatives of erythromycin, methods for their preparation and use as medicines MD663G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (en) 1994-04-08 1994-04-08 New erythromycin derivatives, their preparation process and their use as drugs.
PCT/FR1995/000441 WO1995027720A1 (en) 1994-04-08 1995-04-06 Novel erythromycin derivatives, method for preparing same and use thereof as drugs

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (en) 1997-01-31
MD663G2 true MD663G2 (en) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (en) 1994-04-08 1995-04-06 Derivatives of erythromycin, methods for their preparation and use as medicines

Country Status (49)

Country Link
US (2) US5656607A (en)
EP (1) EP0676409B1 (en)
JP (1) JP3000023B2 (en)
KR (1) KR100317148B1 (en)
CN (1) CN1059445C (en)
AP (1) AP587A (en)
AT (1) ATE234853T1 (en)
AU (1) AU684939B2 (en)
BG (1) BG61916B1 (en)
BR (1) BR9506147A (en)
CA (1) CA2164638C (en)
CO (1) CO4370097A1 (en)
CZ (1) CZ296005B6 (en)
DE (1) DE69529934T2 (en)
DK (1) DK0676409T3 (en)
DZ (1) DZ1869A1 (en)
EE (1) EE04498B1 (en)
ES (1) ES2189820T3 (en)
FI (1) FI111264B (en)
FR (1) FR2718450B1 (en)
GB (1) GB2288174A (en)
GE (1) GEP19991836B (en)
HR (1) HRP950217B1 (en)
HU (1) HU215396B (en)
IL (1) IL112954A (en)
IS (1) IS1865B (en)
JO (1) JO1850B1 (en)
LV (1) LV11182B (en)
MA (1) MA23501A1 (en)
MD (1) MD663G2 (en)
MY (1) MY114672A (en)
NO (1) NO308361B1 (en)
NZ (1) NZ284498A (en)
OA (1) OA10200A (en)
PE (1) PE2896A1 (en)
PL (1) PL180837B1 (en)
PT (1) PT676409E (en)
RO (1) RO115634B1 (en)
RU (1) RU2141965C1 (en)
SA (1) SA97170757A (en)
SI (1) SI0676409T1 (en)
SK (1) SK284079B6 (en)
SV (1) SV1995000018A (en)
TN (1) TNSN95026A1 (en)
TW (1) TW316908B (en)
UA (1) UA44705C2 (en)
WO (1) WO1995027720A1 (en)
YU (1) YU49221B (en)
ZA (1) ZA952059B (en)

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FR2732023B1 (en) * 1995-03-22 1997-04-30 Roussel Uclaf NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2742757B1 (en) * 1995-12-22 1998-01-30 Roussel Uclaf NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2745289B1 (en) * 1996-02-28 1998-05-29 Roussel Uclaf NOVEL DERIVATIVES OF CARBOXYLIC ACID 1 (2H) QUINOLEIN, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION TO THE SYNTHESIS OF PRODUCTS WITH ANTIBIOTIC PROPERTIES
CA2253451A1 (en) * 1996-05-07 1997-11-13 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (en) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc NEW PROCESS FOR ISOMERIZATION OF RADICAL METHYL IN 10 FROM ERYTHROMYCIN DERIVATIVES
FR2751656B1 (en) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
SK285534B6 (en) * 1996-09-04 2007-03-01 Abbott Laboratories 6-O-Substituted ketolides having antibacterial activity, pharmaceutical composition comprising its, their use, and method for their preparation
UA51730C2 (en) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-0-substituted ketolides having antibacterial activity
FR2757168B1 (en) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2760017B1 (en) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc NOVEL ERYTROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
WO1998040392A1 (en) * 1997-03-10 1998-09-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (en) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998051696A1 (en) * 1997-05-09 1998-11-19 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
CN1259135A (en) * 1997-06-11 2000-07-05 辉瑞产品公司 9-oxime erythromycin derivatives
FR2771008B1 (en) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc USE OF KETOLIDES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR PREVENTING ARTERIAL THROMBOTIC COMPLICATIONS LINKED TO ATHEROSCLEROSIS
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
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FR2786188B1 (en) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
ES2273964T3 (en) 1998-12-10 2007-05-16 Pfizer Products Inc. CARBAMATE AND CETOLID CARBAZATE ANTIBIOTICS.
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
FR2789392B1 (en) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
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US6395710B1 (en) * 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
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JP2006508643A (en) 2002-07-01 2006-03-16 アーキオン ライフ サイエンシーズ エルエルシー ディー／ビー／エー バイオ−テクニカル リソーセズ ディビジョン Processes and materials for the production of glucosamine and N-acetylglucosamine
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
JP2006524702A (en) * 2003-04-25 2006-11-02 カイロン コーポレイション Pyridyl-substituted ketolide antibody
EP1618120A2 (en) * 2003-04-25 2006-01-25 Chiron Corporation Novel ketolide derivatives
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) * 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (en) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド Method for treating malaria, tuberculosis and MAC disease
CN103080122A (en) 2010-03-22 2013-05-01 森普拉制药公司 Crystalline forms of macrolides and their uses
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (en) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド Hydrogen bond forming fluoroketolides for disease treatment
CN104470527B (en) 2012-03-27 2019-05-28 森普拉制药公司 Parenteral formulations for administration of macrolide antibiotics
RU2015138796A (en) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. METHODS AND COMPOSITIONS FOR TREATMENT OF RESPIRATORY DISEASES
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JP6437523B2 (en) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ Macrolides and methods for their preparation and use
US10633407B2 (en) * 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (en) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Process for treating planting material of flowers before planting
JP7199722B2 (en) 2019-12-25 2023-01-06 旭精工株式会社 Coin transport sorting mechanism and coin identification transport device provided with the same

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EP0596802A1 (en) * 1992-11-05 1994-05-11 Roussel Uclaf Erythromycin derivatives, their process of preparation and their application as medicaments

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Also Published As

Publication number Publication date
YU21695A (en) 1997-12-05
GB2288174A (en) 1995-10-11
GB9506856D0 (en) 1995-05-24
BG100150A (en) 1996-06-28
PE2896A1 (en) 1996-02-12
SK284079B6 (en) 2004-09-08
ES2189820T3 (en) 2003-07-16
LV11182B (en) 1997-04-20
NZ284498A (en) 1997-07-27
TNSN95026A1 (en) 1996-02-06
IL112954A0 (en) 1995-06-29
NO954942L (en) 1996-02-07
JO1850B1 (en) 1995-12-27
HRP950217B1 (en) 2004-06-30
GEP19991836B (en) 1999-11-05
FI111264B (en) 2003-06-30
RO115634B1 (en) 2000-04-28
DK0676409T3 (en) 2003-06-23
US5656607A (en) 1997-08-12
EE04498B1 (en) 2005-06-15
SK154695A3 (en) 1996-10-02
PT676409E (en) 2003-08-29
KR100317148B1 (en) 2002-06-22
JP3000023B2 (en) 2000-01-17
HRP950217A2 (en) 1997-08-31
CZ322395A3 (en) 1996-08-14
IS1865B (en) 2003-05-02
EP0676409A1 (en) 1995-10-11
US5760233A (en) 1998-06-02
CA2164638C (en) 2003-12-30
DZ1869A1 (en) 2002-02-17
CA2164638A1 (en) 1995-10-19
JPH07278177A (en) 1995-10-24
FI955913A0 (en) 1995-12-08
CZ296005B6 (en) 2005-12-14
CN1126997A (en) 1996-07-17
FI955913A7 (en) 1995-12-08
OA10200A (en) 1996-12-18
SI0676409T1 (en) 2003-06-30
BG61916B1 (en) 1998-09-30
SA97170757A (en) 2005-12-03
MA23501A1 (en) 1995-12-31
AP587A (en) 1997-04-29
ATE234853T1 (en) 2003-04-15
IL112954A (en) 2000-07-16
YU49221B (en) 2004-11-25
NO954942D0 (en) 1995-12-06
AU2310795A (en) 1995-10-30
RU2141965C1 (en) 1999-11-27
DE69529934T2 (en) 2003-09-04
MY114672A (en) 2002-12-31
CN1059445C (en) 2000-12-13
SV1995000018A (en) 1997-10-24
BR9506147A (en) 1996-04-16
HU215396B (en) 1998-12-28
NO308361B1 (en) 2000-09-04
EP0676409B1 (en) 2003-03-19
WO1995027720A1 (en) 1995-10-19
LV11182A (en) 1996-04-20
PL311871A1 (en) 1996-03-18
ZA952059B (en) 1996-03-13
HU9503505D0 (en) 1996-02-28
CO4370097A1 (en) 1996-10-07
AP9500743A0 (en) 1995-07-31
TW316908B (en) 1997-10-01
FR2718450A1 (en) 1995-10-13
PL180837B1 (en) 2001-04-30
DE69529934D1 (en) 2003-04-24
HUT73772A (en) 1996-09-30
AU684939B2 (en) 1998-01-08
EE9500080A (en) 1996-12-16
IS4309A (en) 1995-11-17
MD663F1 (en) 1997-01-31
UA44705C2 (en) 2002-03-15
FR2718450B1 (en) 1997-01-10

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Legal Events

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FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees