MD943G2 - Process for obtaining isothiocyanate benzoic acids - Google Patents
Process for obtaining isothiocyanate benzoic acidsInfo
- Publication number
- MD943G2 MD943G2 MD97-0193A MD970193A MD943G2 MD 943 G2 MD943 G2 MD 943G2 MD 970193 A MD970193 A MD 970193A MD 943 G2 MD943 G2 MD 943G2
- Authority
- MD
- Moldova
- Prior art keywords
- benzoic acids
- isothiocyanate
- dimethylthioureas
- obtaining
- sulfuric acid
- Prior art date
Links
- NVJSJYKWUMOKGE-UHFFFAOYSA-N N=C=S.OC(=O)C1=CC=CC=C1 Chemical class N=C=S.OC(=O)C1=CC=CC=C1 NVJSJYKWUMOKGE-UHFFFAOYSA-N 0.000 title abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 4
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- MTJGVAJYTOXFJH-UHFFFAOYSA-N 3-aminonaphthalene-1,5-disulfonic acid Chemical compound C1=CC=C(S(O)(=O)=O)C2=CC(N)=CC(S(O)(=O)=O)=C21 MTJGVAJYTOXFJH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- -1 aromatic isothiocyanates Chemical class 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 239000000417 fungicide Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 230000001069 nematicidal effect Effects 0.000 abstract 1
- 239000005645 nematicide Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to the chemistry, particularly, to the preparation of the aromatic isothiocyanates, containing the carboxylic group and providing the bactericide, fungicide or nematocide activity, and may be used for new biologic active preparations synthesis.Summary of the invention consists in the fact, that isothiocyanate benzoic acids are prepared by removing the dime-thylamine from the corresponding N-aryl-N',N'-dimethylthioureas with mineral acid in the organic medium and N-carboxyaryl-N',N'-dimethylthioureas are used as starting materials, which are warmed with sulfuric acid in dioxane at 80...100°C and sulfuric acid to thiourea derivative molar ratio in the range of 0.5...1.1.The technical result of the invention consists in the isothiocyanate benzoic acids yield increasing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD97-0193A MD943G2 (en) | 1997-07-10 | 1997-07-10 | Process for obtaining isothiocyanate benzoic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD97-0193A MD943G2 (en) | 1997-07-10 | 1997-07-10 | Process for obtaining isothiocyanate benzoic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD943F1 MD943F1 (en) | 1998-03-31 |
| MD943G2 true MD943G2 (en) | 1999-02-28 |
Family
ID=19739032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD97-0193A MD943G2 (en) | 1997-07-10 | 1997-07-10 | Process for obtaining isothiocyanate benzoic acids |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD943G2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4077C1 (en) * | 2010-01-18 | 2011-07-31 | Государственный Университет Молд0 | Process for obtaining N, N-dimethylthioureidobenzoic acids |
| MD4126C1 (en) * | 2010-11-15 | 2012-04-30 | Государственный Университет Молд0 | N,N'-[4,4'-(perfluoro-1,4-phenylenedioxy)-bis(4,1-phenylene)]-bis[2-(pyridine-2-ilmethylene)hydrazinecarbothioamide] and use thereof as prostate cancer LNCaP cell proliferation inhibitor |
-
1997
- 1997-07-10 MD MD97-0193A patent/MD943G2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Antos K., Hulca A., Kristian P., Drobnica L. Chem. Zwesti, 1959, v.13, 27-31. * |
| Tietze E., Petersen Z., Domagk G. Chem. Ber., 1953, B. 86, Nr. 3, S. 313-315. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4077C1 (en) * | 2010-01-18 | 2011-07-31 | Государственный Университет Молд0 | Process for obtaining N, N-dimethylthioureidobenzoic acids |
| MD4126C1 (en) * | 2010-11-15 | 2012-04-30 | Государственный Университет Молд0 | N,N'-[4,4'-(perfluoro-1,4-phenylenedioxy)-bis(4,1-phenylene)]-bis[2-(pyridine-2-ilmethylene)hydrazinecarbothioamide] and use thereof as prostate cancer LNCaP cell proliferation inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| MD943F1 (en) | 1998-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Granted patent for invention | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20170710 |