MD990158A - Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol - Google Patents

Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol

Info

Publication number
MD990158A
MD990158A MD99-0158A MD990158A MD990158A MD 990158 A MD990158 A MD 990158A MD 990158 A MD990158 A MD 990158A MD 990158 A MD990158 A MD 990158A
Authority
MD
Moldova
Prior art keywords
hydrochloride
chlor
dimethylaminoethanol
phenoxyacetate
amidosulphonyl
Prior art date
Application number
MD99-0158A
Other languages
English (en)
Russian (ru)
Inventor
Корнелиу ОНИСКУ
Bibian Stefan Paul Cilianu
Dumitru Dobrescu
Lucian Srgiu HARLES
Ioana Virginia Ducu
Gabriela Funieru
Alexandru Carstea
Original Assignee
Societatea Comerciala Sintofarm S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societatea Comerciala Sintofarm S. A. filed Critical Societatea Comerciala Sintofarm S. A.
Publication of MD990158A publication Critical patent/MD990158A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la domeniul chimiei, în particular la un procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol cu formula (I):care este principiul activ al remediului ROMENER (Meclosulfonat) cu acţiune psihoenergizantă şi anticonvulsivantă.Procedeul de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol include transesterificarea la temperatura de 100°C, timp de 4 ore, a 2-clor-4-dimetil-amidosulfonil-fenoxiacetatului de metil cu N,N-dimetilaminoetanol în prezenţa N,N-dimetilaminoetoxidului de sodiu în calitate de catalizator, separarea uleiului esteric din mediul de reacţie, extracţia şi anhidrizarea lui în benzen la temperatura de până la 10°C, tratarea soluţiei benzenice anhidre cu clorură de hidrogen gazoasă la rece, purificarea produsului final prin recristalizare dintr-un amestec de etanol şi dimetilformamidă.
MD99-0158A 1997-06-30 1998-06-23 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol MD990158A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RO97-01207A RO117318B1 (ro) 1997-06-30 1997-06-30 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amido-sulfonil-fenoxiacetat de n,n-dimetilaminoetanol
PCT/RO1998/000009 WO1999000358A1 (en) 1997-06-30 1998-06-23 Procedure to prepare n,n-dimethylaminoethanol 2-chlor-4-dimethyl-amidosulfonyl-fenoxyacetate hydrochloride

Publications (1)

Publication Number Publication Date
MD990158A true MD990158A (ro) 2000-09-30

Family

ID=20105274

Family Applications (1)

Application Number Title Priority Date Filing Date
MD99-0158A MD990158A (ro) 1997-06-30 1998-06-23 Procedeu de preparare a clorhidratului de 2-clor-4-dimetil-amidosulfonil-fenoxiacetat de N,N-dimetilaminoetanol

Country Status (4)

Country Link
EP (1) EP0922026A1 (ro)
MD (1) MD990158A (ro)
RO (1) RO117318B1 (ro)
WO (1) WO1999000358A1 (ro)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103214382B (zh) * 2013-04-24 2014-04-02 四川省惠达药业有限公司 一种盐酸甲氯芬酯化合物及其药物组合物
CN105106189A (zh) * 2015-09-30 2015-12-02 杨献美 一种促进脑能量代谢的药物盐酸甲氯芬酯组合物
CN105106190A (zh) * 2015-10-09 2015-12-02 杨献美 一种中枢兴奋药盐酸甲氯芬酯组合物
CN105287410A (zh) * 2015-12-01 2016-02-03 青岛华之草医药科技有限公司 治疗外伤性昏迷的药物盐酸甲氯芬酯组合物冻干粉针剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO61526A2 (ro) * 1974-11-22 1977-01-15
RO78977A2 (ro) * 1980-09-20 1982-04-12 Institutul De Cercetari Chimico-Farmaceutice,Ro Procedeu de obtinere a esterilor dimetilaminoetilici ai acizilor amidosulfonilfenoxiacetici
RO110060B1 (ro) * 1993-07-19 1995-01-30 Sc Sintofarm Sa Procedeu de obținere a clorhidraților esterilor dimetilaminoetilici ai acizilor amidosulfonilfenoxiacetici

Also Published As

Publication number Publication date
RO117318B1 (ro) 2002-01-30
WO1999000358A1 (en) 1999-01-07
EP0922026A1 (en) 1999-06-16

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