MEP10109A - Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof - Google Patents

Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof

Info

Publication number: MEP10109A
Authority: ME; Montenegro
Prior art keywords: alkyl; pyridin; thi; therapeutic use; pyrrolizine
Prior art date: 2006-09-22

Application number

MEP-101/09A

Other languages

Bosnian (bs)

English (en)

Croatian (hr)

Inventor

Gihad Dargazanli

Genevieve Estenne-Bouhtou

Florence Medaisko

Maria Carmen Renones

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-22

Filing date

2007-09-21

Publication date

2011-12-20

2007-09-21 Application filed filed Critical

2011-12-20 Publication of MEP10109A publication Critical patent/MEP10109A/xx

Links

230000001225 therapeutic effect Effects 0.000 title abstract 2
125000002152 1H-pyrrolizinyl group Chemical class C1(C=CN2C=CC=C12)* 0.000 title 1
GDRVFDDBLLKWRI-UHFFFAOYSA-N 4H-quinolizine Chemical compound C1=CC=CN2CC=CC=C21 GDRVFDDBLLKWRI-UHFFFAOYSA-N 0.000 title 1
HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical compound C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 title 1
-1 price Chemical group 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Indole Compounds (AREA)

MEP-101/09A 2006-09-22 2007-09-21 Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof MEP10109A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0608348A FR2906251B1 (fr)	2006-09-22	2006-09-22	Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
PCT/FR2007/001545 WO2008037881A2 (fr)	2006-09-22	2007-09-21	Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number	Publication Date
MEP10109A true MEP10109A (en)	2011-12-20

Family

ID=37897398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-101/09A MEP10109A (en)	2006-09-22	2007-09-21	Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof

Country Status (29)

Country	Link
US (2)	US7776880B2 (pt)
EP (1)	EP2077837A2 (pt)
JP (1)	JP2010504311A (pt)
KR (1)	KR20090080947A (pt)
CN (1)	CN101573113A (pt)
AR (1)	AR062896A1 (pt)
AU (1)	AU2007301880A1 (pt)
BR (1)	BRPI0717100A2 (pt)
CA (1)	CA2663080A1 (pt)
CL (1)	CL2007002732A1 (pt)
CO (1)	CO6160309A2 (pt)
CR (1)	CR10658A (pt)
EA (1)	EA015974B1 (pt)
FR (1)	FR2906251B1 (pt)
GT (1)	GT200900061A (pt)
HN (1)	HN2009000504A (pt)
IL (1)	IL197500A0 (pt)
MA (1)	MA30790B1 (pt)
ME (1)	MEP10109A (pt)
MX (1)	MX2009003083A (pt)
NO (1)	NO20091351L (pt)
NZ (1)	NZ575573A (pt)
PE (1)	PE20081376A1 (pt)
SV (1)	SV2009003191A (pt)
TN (1)	TN2009000082A1 (pt)
TW (1)	TW200819455A (pt)
UY (1)	UY30604A1 (pt)
WO (1)	WO2008037881A2 (pt)
ZA (1)	ZA200901850B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2842804B1 (fr)	2002-07-29	2004-09-03	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) *	2003-10-17	2006-04-07	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
WO2010087761A1 (en) *	2009-01-28	2010-08-05	Astrazeneca Ab	2-aza-bicyclo[2.2.2]octane compounds and uses thereof
UY32397A (es) *	2009-01-28	2010-08-31	Astrazeneca Ab	Compuestos de 2-aza-biciclo [2,2,1] heptano y sus usos
US8338441B2 (en)	2009-05-15	2012-12-25	Gilead Sciences, Inc.	Inhibitors of human immunodeficiency virus replication
US8143273B2 (en) *	2010-06-22	2012-03-27	Hoffman-La Roche Inc.	Quinolizidine and indolizidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3801636A (en) *	1971-08-13	1974-04-02	Abbott Lab	3,4,5-tri-substituted cinnamides
US4409225A (en) *	1981-03-16	1983-10-11	Beecham Group Limited	Substituted benzamides
WO1993005040A1 (en) *	1991-09-12	1993-03-18	Smithkline Beecham Plc	Azabicyclic compounds as 5-ht4 receptor antagonists
CZ284456B6 (cs)	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
EP1326863A2 (en) *	2000-09-22	2003-07-16	Ortho-McNeil Pharmaceutical, Inc.	Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
FR2861073B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

2006
- 2006-09-22 FR FR0608348A patent/FR2906251B1/fr not_active Expired - Fee Related
2007
- 2007-09-13 TW TW096134256A patent/TW200819455A/zh unknown
- 2007-09-19 AR ARP070104135A patent/AR062896A1/es unknown
- 2007-09-20 PE PE2007001267A patent/PE20081376A1/es not_active Application Discontinuation
- 2007-09-21 CA CA002663080A patent/CA2663080A1/fr not_active Abandoned
- 2007-09-21 CN CNA2007800392487A patent/CN101573113A/zh active Pending
- 2007-09-21 UY UY30604A patent/UY30604A1/es not_active Application Discontinuation
- 2007-09-21 JP JP2009528756A patent/JP2010504311A/ja not_active Withdrawn
- 2007-09-21 WO PCT/FR2007/001545 patent/WO2008037881A2/fr not_active Ceased
- 2007-09-21 EA EA200970312A patent/EA015974B1/ru not_active IP Right Cessation
- 2007-09-21 ZA ZA200901850A patent/ZA200901850B/xx unknown
- 2007-09-21 CL CL200702732A patent/CL2007002732A1/es unknown
- 2007-09-21 MX MX2009003083A patent/MX2009003083A/es active IP Right Grant
- 2007-09-21 EP EP07848274A patent/EP2077837A2/fr not_active Withdrawn
- 2007-09-21 BR BRPI0717100-5A patent/BRPI0717100A2/pt not_active IP Right Cessation
- 2007-09-21 KR KR1020097008124A patent/KR20090080947A/ko not_active Withdrawn
- 2007-09-21 NZ NZ575573A patent/NZ575573A/en not_active IP Right Cessation
- 2007-09-21 AU AU2007301880A patent/AU2007301880A1/en not_active Abandoned
- 2007-09-21 ME MEP-101/09A patent/MEP10109A/xx unknown
2009
- 2009-03-09 IL IL197500A patent/IL197500A0/en unknown
- 2009-03-10 TN TN2009000082A patent/TN2009000082A1/fr unknown
- 2009-03-11 CR CR10658A patent/CR10658A/es not_active Application Discontinuation
- 2009-03-16 GT GT200900061A patent/GT200900061A/es unknown
- 2009-03-18 HN HN2009000504A patent/HN2009000504A/es unknown
- 2009-03-19 SV SV2009003191A patent/SV2009003191A/es active IP Right Grant
- 2009-03-19 CO CO09028765A patent/CO6160309A2/es unknown
- 2009-03-19 US US12/407,276 patent/US7776880B2/en not_active Expired - Fee Related
- 2009-04-01 NO NO20091351A patent/NO20091351L/no not_active Application Discontinuation
- 2009-04-16 MA MA31786A patent/MA30790B1/fr unknown
2010
- 2010-06-30 US US12/827,614 patent/US20100267766A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2663080A1 (fr)	2008-04-03
SV2009003191A (es)	2009-10-27
CR10658A (es)	2009-06-24
MA30790B1 (fr)	2009-10-01
EP2077837A2 (fr)	2009-07-15
US20100267766A1 (en)	2010-10-21
US7776880B2 (en)	2010-08-17
IL197500A0 (en)	2009-12-24
AU2007301880A1 (en)	2008-04-03
AR062896A1 (es)	2008-12-10
KR20090080947A (ko)	2009-07-27
NZ575573A (en)	2011-12-22
ZA200901850B (en)	2010-06-30
UY30604A1 (es)	2008-05-02
PE20081376A1 (es)	2008-11-07
CL2007002732A1 (es)	2008-04-18
HN2009000504A (es)	2011-10-20
TW200819455A (en)	2008-05-01
CN101573113A (zh)	2009-11-04
CO6160309A2 (es)	2010-05-20
TN2009000082A1 (en)	2010-08-19
JP2010504311A (ja)	2010-02-12
US20090258899A1 (en)	2009-10-15
EA015974B1 (ru)	2012-01-30
NO20091351L (no)	2009-06-22
MX2009003083A (es)	2009-04-02
WO2008037881A2 (fr)	2008-04-03
BRPI0717100A2 (pt)	2013-10-15
FR2906251A1 (fr)	2008-03-28
WO2008037881A3 (fr)	2008-05-22
EA200970312A1 (ru)	2009-12-30
GT200900061A (es)	2010-06-21
FR2906251B1 (fr)	2008-11-07

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