MEP23708A - 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-acetamide derivatives, preparation and use thereof in medicaments - Google Patents

3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-acetamide derivatives, preparation and use thereof in medicaments

Info

Publication number: MEP23708A
Authority: ME; Montenegro
Prior art keywords: alkyl; preparation; pyridazino; indole; medicaments
Prior art date: 2002-04-03

Application number

MEP-237/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Jacques Froissant

Benoit Marabout

Frank Marguet

Frederic Puech

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-03

Filing date

2003-04-02

Publication date

2010-06-10

2003-04-02 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2010-06-10 Publication of MEP23708A publication Critical patent/MEP23708A/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000005956 isoquinolyl group Chemical group 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Diabetes (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Obesity (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

MEP-237/08A 2002-04-03 2003-04-02 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-acetamide derivatives, preparation and use thereof in medicaments MEP23708A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0204158A FR2838124B1 (fr)	2002-04-03	2002-04-03	Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PCT/FR2003/001027 WO2003082874A2 (fr)	2002-04-03	2003-04-02	DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
YUP-869/04A RS51244B (sr)	2002-04-03	2003-04-02	Derivati 3-heteroaril-3,5-dihidro-4-okso-4h-piridazino(4,5- b)-indol-1-acetamida, njihovo dobijanje i primena u terapiji

Publications (1)

Publication Number	Publication Date
MEP23708A true MEP23708A (en)	2010-06-10

Family

ID=28052083

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MEP-237/08A MEP23708A (en)	2002-04-03	2003-04-02	3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-acetamide derivatives, preparation and use thereof in medicaments
MEP-2008-237A ME00081B (me)	2002-04-03	2003-04-02	Derivati 3-heteroaril-3,5-dihidro-4-okso-4h-piridazino (4,5-b)- indol-1-acetamida, njihovo dobijanje i primjena u terapiji

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
MEP-2008-237A ME00081B (me)	2002-04-03	2003-04-02	Derivati 3-heteroaril-3,5-dihidro-4-okso-4h-piridazino (4,5-b)- indol-1-acetamida, njihovo dobijanje i primjena u terapiji

Country Status (28)

Country	Link
US (4)	US7235554B2 (sr)
EP (1)	EP1492792B1 (sr)
JP (2)	JP4575670B2 (sr)
KR (1)	KR100975999B1 (sr)
CN (2)	CN100406459C (sr)
AT (1)	ATE321763T1 (sr)
AU (1)	AU2003240930B2 (sr)
BR (1)	BR0309018A (sr)
CA (1)	CA2481460C (sr)
CY (1)	CY1104998T1 (sr)
DE (1)	DE60304327T2 (sr)
DK (1)	DK1492792T3 (sr)
EA (1)	EA007219B1 (sr)
ES (1)	ES2261940T3 (sr)
FR (1)	FR2838124B1 (sr)
HR (1)	HRP20040911B1 (sr)
IL (2)	IL164257A0 (sr)
IS (1)	IS2483B (sr)
ME (2)	MEP23708A (sr)
MX (1)	MXPA04009635A (sr)
NO (1)	NO329426B1 (sr)
NZ (1)	NZ535741A (sr)
PL (1)	PL372617A1 (sr)
PT (1)	PT1492792E (sr)
RS (1)	RS51244B (sr)
UA (1)	UA77273C2 (sr)
WO (1)	WO2003082874A2 (sr)
ZA (1)	ZA200407945B (sr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006017932A1 (en) *	2004-08-18	2006-02-23	Genesense Technologies Inc.	Small interfering rna molecules against ribonucleotide reductase and uses thereof
JP2009504752A (ja) *	2005-08-19	2009-02-05	シェーリングコーポレイション	治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト
US20120041211A1 (en) *	2009-01-30	2012-02-16	Sythana Suresh Kumar	Novel process for preparing carboxy-containing pyrazoleamido compounds 597
CN105330665B (zh) *	2015-11-04	2017-10-03	衡阳师范学院	一种抑制激肽释放酶klk7的化合物、制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2754262B1 (fr) *	1996-10-08	1998-10-30	Synthelabo	Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2766823B1 (fr) *	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) *	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) *	1999-01-26	2001-02-23	Synthelabo	Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2811897A1 (fr) *	2000-07-24	2002-01-25	Sanofi Synthelabo	UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) *	2000-07-24	2002-01-25	Sanofi Synthelabo	DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) *	2001-12-21	2004-12-03	Sanofi Synthelabo	DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

2002
- 2002-04-03 FR FR0204158A patent/FR2838124B1/fr not_active Expired - Fee Related
2003
- 2003-02-04 UA UA20041008012A patent/UA77273C2/uk unknown
- 2003-04-02 HR HRP20040911 patent/HRP20040911B1/xx not_active IP Right Cessation
- 2003-04-02 CA CA2481460A patent/CA2481460C/en not_active Expired - Fee Related
- 2003-04-02 PL PL03372617A patent/PL372617A1/xx unknown
- 2003-04-02 ES ES03730299T patent/ES2261940T3/es not_active Expired - Lifetime
- 2003-04-02 PT PT03730299T patent/PT1492792E/pt unknown
- 2003-04-02 IL IL16425703A patent/IL164257A0/xx unknown
- 2003-04-02 KR KR1020047015629A patent/KR100975999B1/ko not_active Expired - Fee Related
- 2003-04-02 US US10/509,695 patent/US7235554B2/en not_active Expired - Lifetime
- 2003-04-02 BR BR0309018-3A patent/BR0309018A/pt not_active IP Right Cessation
- 2003-04-02 AU AU2003240930A patent/AU2003240930B2/en not_active Ceased
- 2003-04-02 RS YUP-869/04A patent/RS51244B/sr unknown
- 2003-04-02 AT AT03730299T patent/ATE321763T1/de active
- 2003-04-02 WO PCT/FR2003/001027 patent/WO2003082874A2/fr not_active Ceased
- 2003-04-02 ME MEP-237/08A patent/MEP23708A/xx unknown
- 2003-04-02 EA EA200401146A patent/EA007219B1/ru not_active IP Right Cessation
- 2003-04-02 DE DE60304327T patent/DE60304327T2/de not_active Expired - Lifetime
- 2003-04-02 JP JP2003580339A patent/JP4575670B2/ja not_active Expired - Fee Related
- 2003-04-02 NZ NZ535741A patent/NZ535741A/en not_active IP Right Cessation
- 2003-04-02 MX MXPA04009635A patent/MXPA04009635A/es active IP Right Grant
- 2003-04-02 CN CNB038122227A patent/CN100406459C/zh not_active Expired - Fee Related
- 2003-04-02 DK DK03730299T patent/DK1492792T3/da active
- 2003-04-02 ME MEP-2008-237A patent/ME00081B/me unknown
- 2003-04-02 EP EP03730299A patent/EP1492792B1/fr not_active Expired - Lifetime
- 2003-04-02 CN CNB2006101003182A patent/CN100543016C/zh not_active Expired - Fee Related
2004
- 2004-09-23 IL IL164257A patent/IL164257A/en not_active IP Right Cessation
- 2004-09-30 NO NO20044153A patent/NO329426B1/no not_active IP Right Cessation
- 2004-09-30 IS IS7478A patent/IS2483B/is unknown
- 2004-10-01 ZA ZA2004/07945A patent/ZA200407945B/en unknown
2006
- 2006-06-29 CY CY20061100885T patent/CY1104998T1/el unknown
2007
- 2007-05-16 US US11/749,342 patent/US7323467B2/en not_active Expired - Lifetime
- 2007-10-04 US US11/867,366 patent/US7405306B2/en not_active Expired - Fee Related
2008
- 2008-06-20 US US12/143,059 patent/US20080255129A1/en not_active Abandoned
2010
- 2010-06-22 JP JP2010141683A patent/JP5277208B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IS7478A (is)	2004-09-30
AU2003240930B2 (en)	2009-07-30
RS51244B (sr)	2010-12-31
KR20040094904A (ko)	2004-11-10
NO329426B1 (no)	2010-10-18
EP1492792B1 (fr)	2006-03-29
US7405306B2 (en)	2008-07-29
US7235554B2 (en)	2007-06-26
JP4575670B2 (ja)	2010-11-04
KR100975999B1 (ko)	2010-08-17
CA2481460A1 (en)	2003-10-09
BR0309018A (pt)	2005-02-01
EP1492792A2 (fr)	2005-01-05
HK1074632A1 (zh)	2005-11-18
ES2261940T3 (es)	2006-11-16
UA77273C2 (en)	2006-11-15
EA007219B1 (ru)	2006-08-25
JP2010248221A (ja)	2010-11-04
NZ535741A (en)	2007-03-30
DE60304327D1 (de)	2006-05-18
WO2003082874A2 (fr)	2003-10-09
JP2005527566A (ja)	2005-09-15
CN1656099A (zh)	2005-08-17
DK1492792T3 (da)	2006-08-14
DE60304327T2 (de)	2006-12-28
JP5277208B2 (ja)	2013-08-28
HK1102371A1 (en)	2007-11-16
US20070219202A1 (en)	2007-09-20
CN100406459C (zh)	2008-07-30
MXPA04009635A (es)	2005-07-13
PT1492792E (pt)	2006-08-31
IS2483B (is)	2008-12-15
FR2838124B1 (fr)	2004-05-28
US7323467B2 (en)	2008-01-29
ZA200407945B (en)	2005-11-30
CN100543016C (zh)	2009-09-23
US20050124615A1 (en)	2005-06-09
CA2481460C (en)	2011-02-15
US20080076775A1 (en)	2008-03-27
CY1104998T1 (el)	2009-11-04
NO20044153L (no)	2004-12-27
HRP20040911A2 (en)	2004-12-31
US20080255129A1 (en)	2008-10-16
HRP20040911B1 (en)	2012-11-30
WO2003082874A3 (fr)	2004-04-01
PL372617A1 (en)	2005-07-25
CN1970538A (zh)	2007-05-30
EA200401146A1 (ru)	2005-06-30
ME00081B (me)	2010-10-10
AU2003240930A1 (en)	2003-10-13
FR2838124A1 (fr)	2003-10-10
ATE321763T1 (de)	2006-04-15
IL164257A (en)	2009-11-18
IL164257A0 (en)	2005-12-18
RS86904A (sr)	2006-12-15

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