MX2007016172A - O-desmetilvenlafaxina sustancialmente pura y procesos para prepararla. - Google Patents

O-desmetilvenlafaxina sustancialmente pura y procesos para prepararla.

Info

Publication number: MX2007016172A
Authority: MX; Mexico
Prior art keywords: substantially pure; preparing; desmethylvenlafaxine; demethylvenlafaxine; mixture
Prior art date: 2006-04-17

Application number

MX2007016172A

Other languages

English (en)

Spanish (es)

Inventor

Valerie Niddam-Hildesheim

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-17

Filing date

2007-04-17

Publication date

2008-03-10

2007-04-17 Application filed by Teva Pharma filed Critical Teva Pharma

2008-03-10 Publication of MX2007016172A publication Critical patent/MX2007016172A/es

Links

KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 title claims abstract description 68
238000000034 method Methods 0.000 title claims abstract description 42
239000000203 mixture Substances 0.000 claims description 100
238000004519 manufacturing process Methods 0.000 claims description 77
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 66
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 62
238000004128 high performance liquid chromatography Methods 0.000 claims description 54
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 52
229960004688 venlafaxine Drugs 0.000 claims description 52
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 51
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 claims description 42
239000012535 impurity Substances 0.000 claims description 39
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 36
239000003480 eluent Substances 0.000 claims description 35
239000000725 suspension Substances 0.000 claims description 35
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 24
239000002904 solvent Substances 0.000 claims description 21
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 19
239000003960 organic solvent Substances 0.000 claims description 17
239000000546 pharmaceutical excipient Substances 0.000 claims description 17
239000000243 solution Substances 0.000 claims description 17
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 15
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 15
239000002585 base Substances 0.000 claims description 13
239000003054 catalyst Substances 0.000 claims description 13
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 12
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 11
229910052979 sodium sulfide Inorganic materials 0.000 claims description 11
GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims description 11
239000000126 substance Substances 0.000 claims description 11
238000012360 testing method Methods 0.000 claims description 11
239000002253 acid Substances 0.000 claims description 10
238000009835 boiling Methods 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 10
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
238000004458 analytical method Methods 0.000 claims description 9
239000000843 powder Substances 0.000 claims description 9
238000003756 stirring Methods 0.000 claims description 9
BHCUWXACHAFFSK-UHFFFAOYSA-N 4-[2-amino-1-(1-hydroxycyclohexyl)ethyl]phenol Chemical compound C1CCCCC1(O)C(CN)C1=CC=C(O)C=C1 BHCUWXACHAFFSK-UHFFFAOYSA-N 0.000 claims description 8
238000010438 heat treatment Methods 0.000 claims description 8
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical group [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
238000001556 precipitation Methods 0.000 claims description 8
238000011084 recovery Methods 0.000 claims description 8
150000007944 thiolates Chemical class 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 7
239000003153 chemical reaction reagent Substances 0.000 claims description 7
239000001384 succinic acid Substances 0.000 claims description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
-1 alkyl thiolate Chemical class 0.000 claims description 6
150000007524 organic acids Chemical class 0.000 claims description 6
229910000027 potassium carbonate Inorganic materials 0.000 claims description 6
239000012279 sodium borohydride Substances 0.000 claims description 6
229910000033 sodium borohydride Inorganic materials 0.000 claims description 6
239000012296 anti-solvent Substances 0.000 claims description 5
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
239000012298 atmosphere Substances 0.000 claims description 4
238000002425 crystallisation Methods 0.000 claims description 4
230000008025 crystallization Effects 0.000 claims description 4
239000011734 sodium Substances 0.000 claims description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
239000007900 aqueous suspension Substances 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 3
238000000634 powder X-ray diffraction Methods 0.000 claims description 3
230000005855 radiation Effects 0.000 claims description 3
229910052708 sodium Inorganic materials 0.000 claims description 3
239000012321 sodium triacetoxyborohydride Substances 0.000 claims description 3
DVVGIUUJYPYENY-UHFFFAOYSA-N 1-methylpyridin-2-one Chemical compound CN1C=CC=CC1=O DVVGIUUJYPYENY-UHFFFAOYSA-N 0.000 claims description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
150000001338 aliphatic hydrocarbons Chemical class 0.000 claims description 2
150000008280 chlorinated hydrocarbons Chemical class 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
150000002576 ketones Chemical class 0.000 claims description 2
150000007522 mineralic acids Chemical class 0.000 claims description 2
239000003921 oil Substances 0.000 claims description 2
229910052710 silicon Inorganic materials 0.000 claims description 2
239000010703 silicon Substances 0.000 claims description 2
XRZRPHKMCVBSLA-UHFFFAOYSA-M sodium;dodecane-1-thiolate Chemical group [Na+].CCCCCCCCCCCC[S-] XRZRPHKMCVBSLA-UHFFFAOYSA-M 0.000 claims description 2
229910000288 alkali metal carbonate Inorganic materials 0.000 claims 3
150000008041 alkali metal carbonates Chemical class 0.000 claims 3
239000011877 solvent mixture Substances 0.000 claims 2
230000001335 demethylating effect Effects 0.000 claims 1
238000001514 detection method Methods 0.000 claims 1
235000005985 organic acids Nutrition 0.000 claims 1
239000007787 solid Substances 0.000 description 30
239000011541 reaction mixture Substances 0.000 description 23
239000003826 tablet Substances 0.000 description 16
238000003556 assay Methods 0.000 description 14
239000007788 liquid Substances 0.000 description 14
238000002360 preparation method Methods 0.000 description 13
239000008186 active pharmaceutical agent Substances 0.000 description 12
235000019441 ethanol Nutrition 0.000 description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
239000002552 dosage form Substances 0.000 description 10
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
239000000047 product Substances 0.000 description 9
239000004480 active ingredient Substances 0.000 description 8
239000008187 granular material Substances 0.000 description 8
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
239000002775 capsule Substances 0.000 description 6
229920002472 Starch Polymers 0.000 description 5
239000006227 byproduct Substances 0.000 description 5
238000007907 direct compression Methods 0.000 description 5
239000000796 flavoring agent Substances 0.000 description 5
229910052757 nitrogen Inorganic materials 0.000 description 5
239000008107 starch Substances 0.000 description 5
235000019698 starch Nutrition 0.000 description 5
108010010803 Gelatin Proteins 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
229920002125 Sokalan® Polymers 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
235000013355 food flavoring agent Nutrition 0.000 description 4
229920000159 gelatin Polymers 0.000 description 4
239000008273 gelatin Substances 0.000 description 4
229940014259 gelatin Drugs 0.000 description 4
235000019322 gelatine Nutrition 0.000 description 4
235000011852 gelatine desserts Nutrition 0.000 description 4
239000000463 material Substances 0.000 description 4
229920000609 methyl cellulose Polymers 0.000 description 4
235000010981 methylcellulose Nutrition 0.000 description 4
239000001923 methylcellulose Substances 0.000 description 4
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
QJDUDPQVDAASMV-UHFFFAOYSA-M sodium;ethanethiolate Chemical compound [Na+].CC[S-] QJDUDPQVDAASMV-UHFFFAOYSA-M 0.000 description 4
229940032147 starch Drugs 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 3
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
229920002907 Guar gum Polymers 0.000 description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
235000010643 Leucaena leucocephala Nutrition 0.000 description 3
240000007472 Leucaena leucocephala Species 0.000 description 3
239000005913 Maltodextrin Substances 0.000 description 3
229920002774 Maltodextrin Polymers 0.000 description 3
229920000168 Microcrystalline cellulose Polymers 0.000 description 3
229920000881 Modified starch Polymers 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
235000010443 alginic acid Nutrition 0.000 description 3
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150000004781 alginic acids Chemical class 0.000 description 3
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150000001875 compounds Chemical class 0.000 description 3
230000017858 demethylation Effects 0.000 description 3
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239000003085 diluting agent Substances 0.000 description 3
239000003814 drug Substances 0.000 description 3
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VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 3
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235000019814 powdered cellulose Nutrition 0.000 description 3
235000010413 sodium alginate Nutrition 0.000 description 3
239000000661 sodium alginate Substances 0.000 description 3
229940005550 sodium alginate Drugs 0.000 description 3
239000008247 solid mixture Substances 0.000 description 3
239000000600 sorbitol Substances 0.000 description 3
235000010356 sorbitol Nutrition 0.000 description 3
239000000454 talc Substances 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
229940033134 talc Drugs 0.000 description 3
235000012222 talc Nutrition 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
241000416162 Astragalus gummifer Species 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
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WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
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244000290333 Vanilla fragrans Species 0.000 description 2
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235000012036 Vanilla tahitensis Nutrition 0.000 description 2
235000011054 acetic acid Nutrition 0.000 description 2
229910052783 alkali metal Inorganic materials 0.000 description 2
150000001340 alkali metals Chemical group 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical compound CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 description 2
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BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

MX2007016172A 2006-04-17 2007-04-17 O-desmetilvenlafaxina sustancialmente pura y procesos para prepararla. MX2007016172A (es)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US79280106P	2006-04-17	2006-04-17
US79673906P	2006-05-01	2006-05-01
US87295506P	2006-12-04	2006-12-04
US89916607P	2007-02-01	2007-02-01
US90241807P	2007-02-20	2007-02-20
US90398807P	2007-02-27	2007-02-27
PCT/US2007/009558 WO2007120923A1 (fr)	2006-04-17	2007-04-17	O-desméthylvenlafaxine essentiellement pure et ses procédés de préparation

Publications (1)

Publication Number	Publication Date
MX2007016172A true MX2007016172A (es)	2008-03-10

Family

ID=39750904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX2007016172A MX2007016172A (es)	2006-04-17	2007-04-17	O-desmetilvenlafaxina sustancialmente pura y procesos para prepararla.

Country Status (6)

Country	Link
EP (1)	EP2007708A1 (fr)
JP (1)	JP2008546718A (fr)
CA (1)	CA2646368A1 (fr)
IL (1)	IL193398A0 (fr)
MX (1)	MX2007016172A (fr)
WO (1)	WO2007120923A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2007016179A (es)	2006-04-17	2008-03-11	Teva Pharma	Formas cristalinas de o-desmetilvenlafaxina.
WO2008035369A2 (fr) *	2006-06-30	2008-03-27	Alembic Limited	Nouvelle forme de o-desméthyl venlafaxine
US20080183016A1 (en)	2006-07-26	2008-07-31	Valerie Niddam-Hildesheim	Process for the synthesis of O-desmethylvenlafaxine
WO2008013995A2 (fr) *	2006-07-26	2008-01-31	Teva Pharmaceutical Industries Ltd.	Procédés pour synthétiser le composé o-desméthylvenlafaxine
US20090069601A1 (en) *	2006-07-26	2009-03-12	Valerie Niddam-Hildesheim	Processes for the synthesis of O-desmethylvenlafaxine
ES2334765B1 (es) *	2006-08-04	2010-12-20	Medichem, S.A.	Proceso mejorado para sintetizar la base libre de la desvenlafaxina ysales o solvatos de la misma.
WO2008112313A2 (fr) *	2007-03-14	2008-09-18	Teva Pharmaceutical Industries Ltd.	Procédés pour préparer des états solides de succinate d'o-desméthylvenlafaxine
US20110118357A1 (en) *	2007-10-26	2011-05-19	Generics Limited	Process for preparing o-desmethylvenlafaxine
KR101343027B1 (ko)	2007-11-26	2013-12-18	테바 파마슈티컬 인더스트리즈 리미티드	Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
WO2009084038A2 (fr) *	2007-12-28	2009-07-09	Ind-Swift Laboratories Limited	Procédé amélioré d'élaboration d'o-desméthyl venlafaxine
EP2252574A1 (fr) *	2008-03-06	2010-11-24	Teva Pharmaceutical Industries Ltd.	Procédés de préparation de la o-desméthylvenlafaxine, exempte de ses impuretés dimères
CZ301503B6 (cs)	2008-11-27	2010-03-24	Zentiva, A. S.	Zpusob prípravy desvenlafaxinu a jeho solí
ES2343050B1 (es) *	2008-12-16	2011-06-14	Chemo Iberica, S.A.	Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables.
CZ301820B6 (cs)	2009-02-06	2010-06-30	Zentiva, K.S.	Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs)	2009-07-15	2010-11-10	Zentiva, K. S.	Zpusob prípravy desvenlafaxinu a jeho solí
CA2795023A1 (fr)	2010-03-29	2011-10-06	Pliva Hrvatska D.O.O.	Formes cristallines du fumarate de o-desmethylvenlafaxine
CZ303249B6 (cs)	2010-04-06	2012-06-20	Zentiva, K.S.	Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
US10464873B2 (en)	2017-02-09	2019-11-05	R L Finechem Private Limited	Process for preparation of 1-[2-(dimethyl amino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6197828B1 (en) *	1998-12-01	2001-03-06	Sepracor, Inc.	Derivatives of (+)-venlafaxine and methods of preparing and using the same
CA2368083A1 (fr)	1999-04-06	2000-10-12	Sepracor Inc.	Derives de la venlafaxine et leurs procedes de preparation et utilisation
EA011451B1 (ru)	2001-02-12	2009-04-28	Уайт	Новая соль сукцинат о-десметилвенлафаксина
UA80543C2 (en) *	2001-12-04	2007-10-10	Wyeth Corp	Method for the preparation of o-desmethylvenlafaxine
WO2007071404A1 (fr) *	2005-12-20	2007-06-28	Synthon B.V.	Procédé de fabrication de la desvenlafaxine

2007
- 2007-04-17 EP EP07755727A patent/EP2007708A1/fr not_active Withdrawn
- 2007-04-17 CA CA002646368A patent/CA2646368A1/fr not_active Abandoned
- 2007-04-17 WO PCT/US2007/009558 patent/WO2007120923A1/fr not_active Ceased
- 2007-04-17 JP JP2008517241A patent/JP2008546718A/ja active Pending
- 2007-04-17 MX MX2007016172A patent/MX2007016172A/es unknown
2008
- 2008-08-12 IL IL193398A patent/IL193398A0/en unknown

Also Published As

Publication number	Publication date
WO2007120923A1 (fr)	2007-10-25
EP2007708A1 (fr)	2008-12-31
JP2008546718A (ja)	2008-12-25
IL193398A0 (en)	2009-05-04
CA2646368A1 (fr)	2007-10-25

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EP2007708A1 (fr)	2008-12-31	O-desméthylvenlafaxine essentiellement pure et ses procédés de préparation
US20090292142A1 (en)	2009-11-26	Substantially pure O-desmethylvenlafaxine and processes for preparing it
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US20030191347A1 (en)	2003-10-09	Venlafaxine base
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US20100035994A1 (en)	2010-02-11	Novel hydrate form of o-desmethyl venlafaxine succinate
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US20090012182A1 (en)	2009-01-08	Crystal forms of O-desmethylvenlafaxine succinate
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