MX2008009727A - Procesos para la preparacion de 9-haloacetamidominociclinas. - Google Patents

Procesos para la preparacion de 9-haloacetamidominociclinas.

Info

Publication number
MX2008009727A
MX2008009727A MX2008009727A MX2008009727A MX2008009727A MX 2008009727 A MX2008009727 A MX 2008009727A MX 2008009727 A MX2008009727 A MX 2008009727A MX 2008009727 A MX2008009727 A MX 2008009727A MX 2008009727 A MX2008009727 A MX 2008009727A
Authority
MX
Mexico
Prior art keywords
preparation
haloacetamidominocyclines
processes
haloacetomidominocyclines
glycylcyclines
Prior art date
Application number
MX2008009727A
Other languages
English (en)
Inventor
Judith Aronhime
Tamas Koltai
Evgeny Tsiperman
Slavik Yurkovski
Sofia Gorohovsky-Rosenberg
Sergei Fine
Gorohovsky-Rosenberg Sofia
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of MX2008009727A publication Critical patent/MX2008009727A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención proporciona intermedios sustancialmente puros, 9-haloacetomidominociclinas, y procesos para la preparación de los mismos que son eficaces para la preparación de glicilciclinas, específicamente Tigeciclina.
MX2008009727A 2006-11-30 2007-11-30 Procesos para la preparacion de 9-haloacetamidominociclinas. MX2008009727A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87203306P 2006-11-30 2006-11-30
PCT/US2007/024649 WO2008066908A1 (en) 2006-11-30 2007-11-30 Processes for preparation of 9-haloacetamidominocyclines

Publications (1)

Publication Number Publication Date
MX2008009727A true MX2008009727A (es) 2009-01-09

Family

ID=39262814

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008009727A MX2008009727A (es) 2006-11-30 2007-11-30 Procesos para la preparacion de 9-haloacetamidominociclinas.

Country Status (6)

Country Link
US (1) US20080234504A1 (es)
EP (1) EP2084126A1 (es)
BR (1) BRPI0706517A2 (es)
IL (1) IL198836A0 (es)
MX (1) MX2008009727A (es)
WO (1) WO2008066908A1 (es)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
DE2442829A1 (de) * 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
BRPI0607353A2 (pt) * 2005-02-15 2009-09-01 Wyeth Corp composto de fórmula (i); composição farmacêutica; uso do composto para o tratamento ou controle de infecções bacterianas em animais de sangue quente; processo para a preparação de tetraciclinas 9-(n-substituìdas-n-substituìdas-glicil) de fórmulas 5; 7; 10; e tetraciclina 9-(n-substituìda-n-substituìda glicil) de fómulas 5; 7; 10
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR055336A1 (es) * 2005-06-16 2007-08-22 Wyeth Corp Proeso de elaboracion para la produccion de tigeciclina como un polvo reconstituible, polvo de tigeciclina liofilizado y producto hecho mediante el proceso

Also Published As

Publication number Publication date
EP2084126A1 (en) 2009-08-05
US20080234504A1 (en) 2008-09-25
WO2008066908A1 (en) 2008-06-05
IL198836A0 (en) 2010-02-17
BRPI0706517A2 (pt) 2011-03-29

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal