MX2009005773A - Proceso para la produccion de acido clavulanico. - Google Patents

Proceso para la produccion de acido clavulanico.

Info

Publication number
MX2009005773A
MX2009005773A MX2009005773A MX2009005773A MX2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A MX 2009005773 A MX2009005773 A MX 2009005773A
Authority
MX
Mexico
Prior art keywords
clavulanic acid
metal
acid containing
salt
insoluble
Prior art date
Application number
MX2009005773A
Other languages
English (en)
Inventor
Piotr Wnukowski
Thomas Van Der Does
Bengt Olof Mathias Danielsson
Harold Monro Moody
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2009005773A publication Critical patent/MX2009005773A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con un proceso para la preparación de una sal metálica farmacéuticamente aceptable del ácido clavulánico que comprende las etapas de (a) fermentar con un microorganismo capaz de producir y excretar el ácido clavulánico en el caldo; (b) remover la biomasa y otro material sólido del caldo de fermentación que contiene el ácido clavulánico obtenido en la etapa (a); (c) acidificar la solución obtenida después de la etapa (b) a un pH entre 1 y 3 y extraer la solución acidificada con un solvente parcial o totalmente inmiscible con agua y separar el extracto que contiene el ácido clavulánico; (d) mezclar el extracto que contiene el ácido clavulánico obtenido en la etapa (c) con un donador de metal y al menos un cosolvente adicional para producir una sal metálica de clavulanato preferiblemente cristalina, insoluble, con un rendimiento de al menos 80%; y (e) separar la sal metálica de clavulanato, preferiblemente cristalina, insoluble de la mezcla obtenida en la etapa (d).
MX2009005773A 2006-12-01 2007-11-29 Proceso para la produccion de acido clavulanico. MX2009005773A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125246 2006-12-01
PCT/EP2007/062994 WO2008065160A1 (en) 2006-12-01 2007-11-29 Process for the production of clavulanic acid

Publications (1)

Publication Number Publication Date
MX2009005773A true MX2009005773A (es) 2009-06-08

Family

ID=38030243

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005773A MX2009005773A (es) 2006-12-01 2007-11-29 Proceso para la produccion de acido clavulanico.

Country Status (7)

Country Link
US (1) US20100055749A1 (es)
EP (1) EP2106448A1 (es)
KR (1) KR20090094261A (es)
CN (1) CN101548018A (es)
CA (1) CA2669931A1 (es)
MX (1) MX2009005773A (es)
WO (1) WO2008065160A1 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid
PT867515E (pt) * 1997-03-24 2000-05-31 Cipan Companhia Ind P De Antib Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel
PT101992A (pt) * 1997-04-14 1998-11-30 Cipan Comp Ind Produtora De An Processo de isolamento de um sal de um metal alcalino do acido clavulanico farmaceuticamente aceitavel
CN1312814A (zh) * 1998-07-16 2001-09-12 Dsm公司 制备棒酸盐类及其酯类的改进方法
AU2004283440A1 (en) * 2003-10-10 2005-05-06 Dsm Ip Assets B.V. Activated carbon treatment

Also Published As

Publication number Publication date
WO2008065160A1 (en) 2008-06-05
CN101548018A (zh) 2009-09-30
EP2106448A1 (en) 2009-10-07
US20100055749A1 (en) 2010-03-04
CA2669931A1 (en) 2008-06-05
KR20090094261A (ko) 2009-09-04

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Legal Events

Date Code Title Description
HH Correction or change in general
FA Abandonment or withdrawal