MX2009013169A - Benzamide mglur5 positive allosteric modulators and methods of making and using same. - Google Patents

Benzamide mglur5 positive allosteric modulators and methods of making and using same.

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Publication number
MX2009013169A
MX2009013169A MX2009013169A MX2009013169A MX2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A
Authority
MX
Mexico
Prior art keywords
methods
compounds
making
positive allosteric
allosteric modulators
Prior art date
Application number
MX2009013169A
Other languages
Spanish (es)
Inventor
P Jeffrey Conn
Craig W Lindsley
Charles David Weaver
Alice L Rodriguez
Colleen M Niswender
Carrie K Jones
Richard Williams
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of MX2009013169A publication Critical patent/MX2009013169A/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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Abstract

In one aspect, the invention relates to compounds, including benzamide derivatives and cyclic benzamide derivatives, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
MX2009013169A 2007-06-03 2008-06-03 Benzamide mglur5 positive allosteric modulators and methods of making and using same. MX2009013169A (en)

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Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2109364A4 (en) 2006-12-15 2010-04-14 Abbott Lab Novel oxadiazole compounds
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers
US8389536B2 (en) 2009-10-27 2013-03-05 Hoffmann-La Roche Inc. Positive allosteric modulators (PAM)
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
US8772301B2 (en) 2009-12-18 2014-07-08 Sunovion Pharmaceuticals, Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
CN102666551B (en) 2009-12-18 2014-12-10 詹森药业有限公司 Bicyclic thiazoles as allosteric modulators of MGLUR5 receptors
WO2011073339A1 (en) 2009-12-18 2011-06-23 Janssen Pharmaceutica Nv Bicyclic thiazoles as allosteric modulators of mglur5 receptors
NZ601267A (en) 2009-12-23 2014-03-28 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
US8420661B2 (en) 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
WO2011149963A1 (en) * 2010-05-24 2011-12-01 Vanderbilt University Substituted-6-methylnicotinamides as mglur5 positive allosteric modulators
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US8772300B2 (en) * 2011-04-19 2014-07-08 Hoffmann-La Roche Inc. Phenyl or pyridinyl-ethynyl derivatives
HRP20150555T1 (en) * 2011-04-26 2015-07-03 F. Hoffmann - La Roche Ag Ethynyl derivatives as positive allosteric modulators of the mglur5
EP2702050B1 (en) 2011-04-26 2016-05-18 F.Hoffmann-La Roche Ag Pyrazolidin-3-one derivatives
EP2723739B1 (en) 2011-06-22 2016-08-24 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (en) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Ethinyl derivatives as allosteric modulators of metabotropic glutamate receptor 5 mglur
UA110995C2 (en) 2011-10-07 2016-03-10 Ф. Хоффманн-Ля Рош Аг ETHINYL DERIVATIVES AS MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR
BR112014015197A8 (en) * 2011-12-21 2017-06-13 Novira Therapeutics Inc hepatitis b antiviral agents
RS58514B1 (en) 2012-06-13 2019-04-30 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
AU2013292142B2 (en) 2012-07-17 2017-03-09 F. Hoffmann-La Roche Ag Arylethynyl derivatives
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
UA113223C2 (en) 2012-08-13 2016-12-26 ARYLETINYLPYRIMIDINE
EP2900659B1 (en) 2012-09-27 2016-08-24 F. Hoffmann-La Roche AG Arylethynyl derivatives
CN104718191B (en) * 2012-10-18 2016-06-29 霍夫曼-拉罗奇有限公司 Ethynyl derivatives serving as MGLUR5 receptor activity modulators
WO2014060398A1 (en) * 2012-10-18 2014-04-24 F. Hoffmann-La Roche Ag Ethynyl derivatives as modulators of mglur5 receptor activity
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
PH12015502383B1 (en) 2013-04-19 2023-02-03 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
EA029352B1 (en) * 2013-09-25 2018-03-30 Ф. Хоффманн-Ля Рош Аг Ethynyl derivatives
TWI649310B (en) * 2014-01-10 2019-02-01 赫孚孟拉羅股份公司 Acetylene derivative
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
TWI712601B (en) 2015-02-20 2020-12-11 美商英塞特公司 Bicyclic heterocycles as fgfr inhibitors
TWI713497B (en) 2015-02-26 2020-12-21 南韓商愛思開生物製藥股份有限公司 Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
CN106146391A (en) * 2015-04-15 2016-11-23 中国科学院上海药物研究所 Substituted benzamide compound of 5-fragrance alkynyl and preparation method thereof, pharmaceutical composition and purposes
RS60199B1 (en) 2015-06-03 2020-06-30 Hoffmann La Roche Ethynyl derivatives
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
WO2017007756A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc Hetero-halo inhibitors of histone deacetylase
UA120463C2 (en) 2015-07-15 2019-12-10 Ф. Хоффманн-Ля Рош Аг ETHYNILE DERIVATIVES AS MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
WO2018015235A1 (en) 2016-07-18 2018-01-25 F. Hoffmann-La Roche Ag Ethynyl derivatives
HUE057849T2 (en) 2017-01-11 2022-06-28 Alkermes Inc Bicyclic inhibitors of histone deacetylase
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
LT3664802T (en) 2017-08-07 2022-06-27 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
HRP20241288T1 (en) 2018-05-04 2024-12-06 Incyte Corporation Solid forms of an fgfr inhibitor and processes for preparing the same
AU2019262579B2 (en) 2018-05-04 2024-09-12 Incyte Corporation Salts of an FGFR inhibitor
DE102019200805A1 (en) * 2019-01-23 2020-07-23 Henkel Ag & Co. Kgaa New fluorescent materials based on phthalimides
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3157361A1 (en) 2019-10-14 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
JP7832891B2 (en) 2019-12-04 2026-03-18 インサイト・コーポレイション Derivatives of FGFR inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
CR20230057A (en) 2020-07-02 2023-08-15 Incyte Corp Tricyclic urea compounds as jak2 v617f inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
EP4190770A4 (en) * 2020-07-29 2024-07-31 Vivozon, Inc. DUAL REGULATOR FOR MGLUR5 AND 5-HT2A RECEPTORS AND ITS USE
JP2023539463A (en) 2020-08-17 2023-09-14 アリゴス セラピューティクス インコーポレイテッド Methods and compositions for targeting PD-L1
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
IL302906A (en) * 2020-11-20 2023-07-01 Denali Therapeutics Inc Compounds, preparations and methods
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
AR125273A1 (en) 2021-02-25 2023-07-05 Incyte Corp SPIROCYCLIC LACTAMS AS JAK2 INHIBITORS V617F
WO2022221170A1 (en) 2021-04-12 2022-10-20 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
CA3220155A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN116514790A (en) * 2022-01-24 2023-08-01 华东师范大学 Tri-aromatic heterocyclic piperazine small molecular organic compound targeting STAT3 and application thereof
CA3247765A1 (en) * 2022-01-27 2025-07-10 Vivozon,Inc. Pharmaceutical composition for prevention or treating mental disorder
AU2023235313A1 (en) 2022-03-17 2024-10-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
WO2026072192A1 (en) * 2024-09-27 2026-04-02 Alto Neuroscience, Inc. Effective treatment of depression in patients having poor cognition or impaired learning and/or memory with a mglur5 positive allosteric modulator

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
JP4425628B2 (en) * 2001-07-23 2010-03-03 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド Cytoprotective compounds, pharmaceutical and cosmetic formulations and methods
WO2004009549A2 (en) * 2002-07-18 2004-01-29 Actelion Pharmaceuticals Ltd Piperidines useful for the treatment of central nervous system disorders
CA2519954A1 (en) * 2003-03-26 2004-10-14 Merck & Co., Inc. Benzamide modulators of metabotropic glutamate receptors
MXPA06003951A (en) * 2003-10-07 2006-06-27 Renovis Inc Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same.
GB0324159D0 (en) * 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
JPWO2005108399A1 (en) * 2004-05-10 2008-03-21 萬有製薬株式会社 Imidazopyridine compounds
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
EP1853269A4 (en) * 2005-02-28 2011-09-07 Renovis Inc Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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