MX2013014239A - Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo. - Google Patents

Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo.

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Publication number
MX2013014239A
MX2013014239A MX2013014239A MX2013014239A MX2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A
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Mexico
Prior art keywords
viral
pharmaceutically acceptable
active ingredient
composition containing
pharmaceutical composition
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MX2013014239A
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English (en)
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MX355498B (es
Inventor
Johan Neyts
Young Sik Jung
Chong Kgo Lee
Hae Soon Kim
Pil Ho Kim
Soo Bong Han
Hendrik Jan Thibaut
Ihl Young Choi
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Univ Leuven Kath
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Publication of MX2013014239A publication Critical patent/MX2013014239A/es
Publication of MX355498B publication Critical patent/MX355498B/es

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Abstract

Se describe derivados de 1,3-Dioxoindeno, sales farmacéuticamente aceptables de los mismos o enantiómeros, un método de preparación de los mismos, y una composición farmacéutica para la prevención o tratamiento de enfermedades virales, que comprenden los mismos como un ingrediente activo. Los derivados de 1,3-Dioxoindeno tienen excelente actividad inhibitoria contra picornavirus incluyendo virus coxsackie, enterovirus, ecovirus, poliovirus y rinovirus, así como exhiben baja citotoxicidad, de modo que pueden ser útiles como un ingrediente activo de una composición farmacéutica para la prevención y tratamiento de enfermedades virales incluyendo poliomielitis, parálisis, conjuntivitis hemorrágica aguda, meningitis viral, enfermedad de manos pies y boca, enfermedad vesicular, hepatitis A, miositis, miocarditis, pancreatitis, diabetes, mialgia epidémica, encefalitis, resfriado, herpangina, enfermedad de pies y boca, asma, enfermedad pulmonar obstructiva crónica, neumonía, sinusitis u otitis media.
MX2013014239A 2011-06-16 2012-06-18 Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo. MX355498B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110058704 2011-06-16
PCT/KR2012/004804 WO2012173447A2 (ko) 2011-06-16 2012-06-18 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물
KR1020120065023A KR101391745B1 (ko) 2011-06-16 2012-06-18 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물

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MX2013014239A true MX2013014239A (es) 2014-05-14
MX355498B MX355498B (es) 2018-04-20

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CN (1) CN103748060B (es)
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PT3882244T (pt) * 2012-12-14 2025-04-04 Univ Leuven Kath Composto, sal farmaceuticamente aceitável ou isómero ótico do mesmo, método para a sua preparação e composição farmacêutica para prevenção ou tratamento de doenças virais que contenha o mesmo como ingrediente ativo
CN104557559B (zh) * 2015-01-14 2016-08-17 成都中医药大学 茚满二酮手性环己烷螺环化合物及其制备方法与用途
KR102067858B1 (ko) 2016-05-24 2020-01-17 주식회사 엘지화학 화합물 및 이를 포함하는 색재 조성물 및 이를 포함하는 수지 조성물
KR102894005B1 (ko) 2020-04-20 2025-12-03 노파르티스 아게 항바이러스 1,3-다이-옥소-인덴 화합물
CN115916763B (zh) * 2020-04-20 2025-06-03 诺华股份有限公司 抗病毒素1,3-二氧代茚化合物

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GB1425295A (en) * 1974-01-23 1976-02-18 Rizh Politekhn I Alpha-aminoylidenephthalides and processes for their preparation
GB1533388A (en) * 1975-02-07 1978-11-22 Creat Ninhydrin-phenol condensation products their preparation and use as therapeutic agents
FR2392951A2 (fr) * 1975-02-07 1978-12-29 Creat Lab Nouveaux derives de la ninhydrine, leurs procedes de preparation et medicaments contenant ces derives
GB8327598D0 (en) * 1983-10-14 1983-11-16 Akzo Nv Pharmacologically active diarylindane-13-diones
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
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ATE277017T1 (de) * 1999-08-30 2004-10-15 Maruishi Pharma 1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen
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RU2566761C2 (ru) 2015-10-27
AU2012270310A1 (en) 2012-12-20
PT2722322T (pt) 2019-09-27
WO2012173447A2 (ko) 2012-12-20
EA025384B1 (ru) 2016-12-30
EP2722322A2 (en) 2014-04-23
KR101391745B1 (ko) 2014-05-07
CN103748060A (zh) 2014-04-23
EP2722322B8 (en) 2020-03-11
EP4360710A2 (en) 2024-05-01
EP4360710A3 (en) 2024-08-07
CA2838680C (en) 2018-01-02
AU2012270310B2 (en) 2016-01-28
MX355498B (es) 2018-04-20
EP2722322A4 (en) 2014-12-17
BR112013032273A2 (pt) 2016-12-20
US9346749B2 (en) 2016-05-24
WO2012173447A3 (ko) 2013-04-04
US9833423B2 (en) 2017-12-05
US20160272564A1 (en) 2016-09-22
US20140121187A1 (en) 2014-05-01
JP2014523416A (ja) 2014-09-11
SI2722322T1 (sl) 2019-11-29
EA201490025A1 (ru) 2014-05-30
EP2722322B1 (en) 2019-06-12
PL2722322T3 (pl) 2020-02-28
JP2016185967A (ja) 2016-10-27
JP5941142B2 (ja) 2016-06-29
JP6373297B2 (ja) 2018-08-15
CA2838680A1 (en) 2012-12-20
EP3611158B1 (en) 2023-12-20
AU2012270310A8 (en) 2014-01-23
RU2014101179A (ru) 2015-07-27
CN103748060B (zh) 2016-04-13
BR112013032273B1 (pt) 2020-11-17
KR20120139606A (ko) 2012-12-27
ES2744982T3 (es) 2020-02-27

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