MX2014007719A - Derivados de amida ciclica como inhibidores de 11 -beta-hidroxiesteroide deshidrogenasa y los usos de los mismos. - Google Patents

Derivados de amida ciclica como inhibidores de 11 -beta-hidroxiesteroide deshidrogenasa y los usos de los mismos.

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Publication number
MX2014007719A
MX2014007719A MX2014007719A MX2014007719A MX2014007719A MX 2014007719 A MX2014007719 A MX 2014007719A MX 2014007719 A MX2014007719 A MX 2014007719A MX 2014007719 A MX2014007719 A MX 2014007719A MX 2014007719 A MX2014007719 A MX 2014007719A
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MX
Mexico
Prior art keywords
compounds
treatment
amide derivatives
hydroxysteroid dehydrogenase
inhibitors
Prior art date
Application number
MX2014007719A
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English (en)
Other versions
MX354361B (es
Inventor
Nagarajan Arumugam
Jenson George
Ramamoorthy Kottamalai
Jagannath Madanahalli Ranganath Rao
Uppala Venkatesham
Sivanageswara Rao Doppalapudi
Bommegowda Yadaganahalli Kenchegowda
George Fernand
G R Madhavan
Mohammed Ansari
K Murugavel
Jidugu Pradeep
Sulthan Allavuddeen
K Vijayaramalingam
Hampelingaiah Shiva Prasad
Augustine Michael Raj
S Gnanavel
Naresh M P S Babu
Original Assignee
Connexios Life Sciences Pvt Ltd
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Application filed by Connexios Life Sciences Pvt Ltd filed Critical Connexios Life Sciences Pvt Ltd
Publication of MX2014007719A publication Critical patent/MX2014007719A/es
Publication of MX354361B publication Critical patent/MX354361B/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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Abstract

La presente invención se relaciona a ciertos derivados de amida que tienen la capacidad para inhibir 11-ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD-1) y las cuales son por lo tanto útiles en el tratamiento de ciertos trastornos que pueden prevenirse o tratarse por medio de la inhibición de esta enzima. Además, la invención se relaciona a compuestos, métodos para su preparación, composiciones farmacéuticas que contienen los compuestos y los usos de estos compuestos en el tratamiento de ciertos trastornos. Se espera que los compuestos de la invención encontrará aplicación en el tratamiento de condiciones tales como diabetes mellitus tipo 2 no dependiente a la insulina (NIDDM), resistencia a la insulina, obesidad, glucosa en ayuno disminuida, tolerancia a la glucosa disminuida, trastornos de lípidos tales como dislipidemia, hipertensión y así como otras enfermedades y condiciones.
MX2014007719A 2011-12-22 2012-12-21 Derivados de amida ciclica como inhibidores de 11 -beta-hidroxiesteroide deshidrogenasa y los usos de los mismos. MX354361B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4527CH2011 2011-12-22
PCT/IN2012/000841 WO2013128465A1 (en) 2011-12-22 2012-12-21 Cyclic amide derivatives as inhibitors of 11 - beta - hydroxysteroid dehydrogenase and uses thereof

Publications (2)

Publication Number Publication Date
MX2014007719A true MX2014007719A (es) 2015-03-19
MX354361B MX354361B (es) 2018-02-28

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MX2014007719A MX354361B (es) 2011-12-22 2012-12-21 Derivados de amida ciclica como inhibidores de 11 -beta-hidroxiesteroide deshidrogenasa y los usos de los mismos.

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US (1) US9453014B2 (es)
EP (1) EP2800748B1 (es)
JP (1) JP6118340B2 (es)
KR (1) KR102083040B1 (es)
CN (1) CN104125956B (es)
AU (1) AU2012372019B2 (es)
BR (1) BR112014015301A8 (es)
CA (1) CA2860187C (es)
CL (1) CL2014001704A1 (es)
CO (1) CO7160013A2 (es)
DK (1) DK2800748T3 (es)
ES (1) ES2630309T3 (es)
IL (1) IL233270A0 (es)
MA (1) MA35874B1 (es)
MX (1) MX354361B (es)
MY (1) MY173696A (es)
PH (1) PH12014501442B1 (es)
RU (1) RU2669695C2 (es)
SG (1) SG11201403268QA (es)
WO (1) WO2013128465A1 (es)
ZA (1) ZA201405263B (es)

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WO2013052381A2 (en) 2011-10-05 2013-04-11 Nitto Denko Corporation Wavelength conversion film having pressure sensitive adhesive layer to enhance solar harvesting efficiency
AR089284A1 (es) 2011-12-22 2014-08-13 Galapagos Nv Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
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CA3050635A1 (en) 2017-02-24 2018-03-01 The Regents Of The University Of California Compositions and methods for promoting hair growth with mpc inhibitors
PH12019502776A1 (en) * 2017-06-30 2020-10-26 Univ California Compositions and methods for modulating hair growth
US12559490B2 (en) 2020-06-30 2026-02-24 The Regents Of The University Of California Compositions and methods for modulating hair growth
WO2022013684A1 (en) 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
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ZA201405263B (en) 2016-05-25
CN104125956B (zh) 2019-08-16
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WO2013128465A1 (en) 2013-09-06
KR102083040B1 (ko) 2020-02-28
US20150158860A1 (en) 2015-06-11
PH12014501442A1 (en) 2014-10-08
MY173696A (en) 2020-02-17
CN104125956A (zh) 2014-10-29
CA2860187C (en) 2020-11-10
RU2669695C2 (ru) 2018-10-15
JP6118340B2 (ja) 2017-04-19
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US9453014B2 (en) 2016-09-27
MA35874B1 (fr) 2014-12-01
BR112014015301A8 (pt) 2017-07-04
PH12014501442B1 (en) 2014-10-08
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