MX2015012005A - Inhibidores de bromodominio. - Google Patents

Inhibidores de bromodominio.

Info

Publication number
MX2015012005A
MX2015012005A MX2015012005A MX2015012005A MX2015012005A MX 2015012005 A MX2015012005 A MX 2015012005A MX 2015012005 A MX2015012005 A MX 2015012005A MX 2015012005 A MX2015012005 A MX 2015012005A MX 2015012005 A MX2015012005 A MX 2015012005A
Authority
MX
Mexico
Prior art keywords
bromodomain inhibitors
compounds
formula
diseases
aids
Prior art date
Application number
MX2015012005A
Other languages
English (en)
Inventor
John K Pratt
Kevin R Woller
Keith F Mcdaniel
Dachun Liu
George S Sheppard
Carol K Wada
Lisa A Hasvold
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2015012005A publication Critical patent/MX2015012005A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La presente invención se proporciona para compuesto de la formula (I) en donde R1, R2, A1, A2, A3, A4, X, e Y tienen cualquiera de los valores definidos en la especificación, y sales farmacéuticamente aceptables del mismo, que son útiles como agentes en el tratamiento de enfermedades y afecciones, que incluyen enfermedades inflamatorias, cáncer, y SIDA. También se proporcionan composiciones farmacéuticas que comprenden uno o más compuestos de la formula (I).
MX2015012005A 2013-03-11 2014-03-11 Inhibidores de bromodominio. MX2015012005A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776530P 2013-03-11 2013-03-11
PCT/US2014/023437 WO2014164771A1 (en) 2013-03-11 2014-03-11 Bromodomain inhibitors

Publications (1)

Publication Number Publication Date
MX2015012005A true MX2015012005A (es) 2016-04-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012005A MX2015012005A (es) 2013-03-11 2014-03-11 Inhibidores de bromodominio.

Country Status (9)

Country Link
US (1) US9050346B2 (es)
EP (1) EP2970262A1 (es)
JP (1) JP2016512524A (es)
CN (1) CN105164127A (es)
AU (1) AU2014249025A1 (es)
BR (1) BR112015022861A8 (es)
CA (1) CA2904048A1 (es)
MX (1) MX2015012005A (es)
WO (1) WO2014164771A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
EA035469B1 (ru) 2013-03-15 2020-06-22 Инсайт Холдингс Корпорейшн Трициклические гетероциклы как ингибиторы белков бэт
KR102307566B1 (ko) 2013-06-21 2021-10-05 제니쓰 에피제네틱스 리미티드 신규한 바이사이클릭 브로모도메인 억제제
CN105473581B (zh) 2013-06-21 2019-04-23 齐尼思表观遗传学有限公司 作为溴结构域抑制剂的新取代的双环化合物
EP3019502B1 (en) 2013-07-08 2017-05-17 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
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