MX2016014875A - Vesiculas extracelulares gigantes inmunogenicas de protozoos parasitos y metodos para su induccion y purificacion. - Google Patents
Vesiculas extracelulares gigantes inmunogenicas de protozoos parasitos y metodos para su induccion y purificacion.Info
- Publication number
- MX2016014875A MX2016014875A MX2016014875A MX2016014875A MX2016014875A MX 2016014875 A MX2016014875 A MX 2016014875A MX 2016014875 A MX2016014875 A MX 2016014875A MX 2016014875 A MX2016014875 A MX 2016014875A MX 2016014875 A MX2016014875 A MX 2016014875A
- Authority
- MX
- Mexico
- Prior art keywords
- vesicles
- vegs
- induction
- purification
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/10—Protozoa; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a vesículas secretadas (extracelulares) gigantes (que denominamos VEGs) que están asociadas a especies de protozoos parásitos, las cuales tienen dimensiones de 500-4000 nm de diámetro, así como a métodos que permiten su inducción, secreción y purificación. Dichas vesículas poseen actividad proteolítica y se componen por una gran cantidad de proteínas; en particular se lograron obtener de trofozoítos de Entamoeba histolytica (que denominamos EhVEG), así como de otros protozoos parásitos, como por ejemplo Giardia lamblia y Tiypanosoma cruzi. La invención también se refiere al uso de estas vesículas, por ejemplo EhVEGs, para inmunizar mamíferos susceptibles de infección por Entamoeba histolytica. Se describen también composiciones farmacéuticas inmunogénicas vacu naJes efectivas que comprenden las VEGs inducidas y aisladas, por ejemplo EhVEGs que resultan útiles para el abceso hepático amibiano. La presente invención representa el primer reporte que demuestra y/o comprueba que E. histolytica secreta vesículas extracelulares de grandes dimensiones al medio de cultivo.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2016014875A MX2016014875A (es) | 2016-11-11 | 2016-11-11 | Vesiculas extracelulares gigantes inmunogenicas de protozoos parasitos y metodos para su induccion y purificacion. |
| PCT/IB2017/056917 WO2018087644A2 (en) | 2016-11-11 | 2017-11-06 | Immunogenic giant extracellular vesicles (vegs) of parasitic protozoa and methods for their induction and purification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2016014875A MX2016014875A (es) | 2016-11-11 | 2016-11-11 | Vesiculas extracelulares gigantes inmunogenicas de protozoos parasitos y metodos para su induccion y purificacion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016014875A true MX2016014875A (es) | 2018-05-10 |
Family
ID=62109610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014875A MX2016014875A (es) | 2016-11-11 | 2016-11-11 | Vesiculas extracelulares gigantes inmunogenicas de protozoos parasitos y metodos para su induccion y purificacion. |
Country Status (2)
| Country | Link |
|---|---|
| MX (1) | MX2016014875A (es) |
| WO (1) | WO2018087644A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024033684A1 (en) * | 2022-08-09 | 2024-02-15 | Universidade De Coimbra | Compositions, methods and uses of extracellular vesicles of giardia spp |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1498144A1 (en) * | 2003-07-15 | 2005-01-19 | Universite Pierre Et Marie Curie Paris Vi | Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell |
-
2016
- 2016-11-11 MX MX2016014875A patent/MX2016014875A/es unknown
-
2017
- 2017-11-06 WO PCT/IB2017/056917 patent/WO2018087644A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018087644A2 (en) | 2018-05-17 |
| WO2018087644A3 (en) | 2018-07-12 |
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