MX2017005242A - Particulas tipo virus modificadas de cmv. - Google Patents

Particulas tipo virus modificadas de cmv.

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Publication number
MX2017005242A
MX2017005242A MX2017005242A MX2017005242A MX2017005242A MX 2017005242 A MX2017005242 A MX 2017005242A MX 2017005242 A MX2017005242 A MX 2017005242A MX 2017005242 A MX2017005242 A MX 2017005242A MX 2017005242 A MX2017005242 A MX 2017005242A
Authority
MX
Mexico
Prior art keywords
cmv
vlps
particles
virus
cell epitopes
Prior art date
Application number
MX2017005242A
Other languages
English (en)
Other versions
MX387985B (es
Inventor
Bachmann Martin
Zeltins Andris
Pumpens Paul
Original Assignee
Saiba Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337283&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017005242(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Saiba Gmbh filed Critical Saiba Gmbh
Publication of MX2017005242A publication Critical patent/MX2017005242A/es
Publication of MX387985B publication Critical patent/MX387985B/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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Abstract

La presente invención se refiere a partículas tipo virus (VLPs por sus siglas en inglés) del virus de plantas Virus del Mosaico del Pepino (CMV por sus siglas en inglés), y en particular a VLPs de CMV que comprenden epítopos de células Th, en particular epítopos de células Th universales. Además, estas VLPs modificadas sirven como, preferentemente, plataforma de vacuna, para la generación de respuestas inmunes, en respuestas de anticuerpos particulares, contra los antígenos vinculados con dichas VLPs modificadas. La presencia de los epítopos de células Th, en particular epítopos de células Th universales, condujo a un mayor aumento en la respuesta inmune generada.
MX2017005242A 2014-10-22 2015-10-20 Particulas tipo virus modificadas de cmv. MX387985B (es)

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PCT/EP2015/074269 WO2016062720A1 (en) 2014-10-22 2015-10-20 Modified virus-like particles of cmv

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