MX2017007430A - Derivados triciclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicacion del virus sincitial respiratorio (vsr). - Google Patents
Derivados triciclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicacion del virus sincitial respiratorio (vsr).Info
- Publication number
- MX2017007430A MX2017007430A MX2017007430A MX2017007430A MX2017007430A MX 2017007430 A MX2017007430 A MX 2017007430A MX 2017007430 A MX2017007430 A MX 2017007430A MX 2017007430 A MX2017007430 A MX 2017007430A MX 2017007430 A MX2017007430 A MX 2017007430A
- Authority
- MX
- Mexico
- Prior art keywords
- respiratory syncytial
- syncytial virus
- rsv
- replication
- inhibitory activity
- Prior art date
Links
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 title 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a nuevos compuestos de pirazolo-pirimidina tricíclicos sustituidos de fórmula (I-a) o (I-b) que tienen actividad antivírica, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincitial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de una infección provocada por el virus sincitial respiratorio. (ver Fórmulas).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196789 | 2014-12-08 | ||
| PCT/EP2015/078796 WO2016091791A1 (en) | 2014-12-08 | 2015-12-07 | Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017007430A true MX2017007430A (es) | 2017-09-28 |
| MX368323B MX368323B (es) | 2019-09-27 |
Family
ID=52006930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017007430A MX368323B (es) | 2014-12-08 | 2015-12-07 | Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr). |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10131673B2 (es) |
| EP (1) | EP3230288B1 (es) |
| JP (1) | JP6703989B2 (es) |
| KR (1) | KR102486023B1 (es) |
| CN (1) | CN107207512B (es) |
| AU (1) | AU2015359562B2 (es) |
| CA (1) | CA2963054C (es) |
| EA (1) | EA030636B1 (es) |
| ES (1) | ES2711334T3 (es) |
| MX (1) | MX368323B (es) |
| SG (1) | SG11201704508WA (es) |
| WO (1) | WO2016091791A1 (es) |
| ZA (1) | ZA201703900B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015359624B2 (en) | 2014-12-08 | 2020-01-02 | Janssen Sciences Ireland Uc | Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV) |
| CN111670189A (zh) * | 2018-01-31 | 2020-09-15 | 爱尔兰詹森科学公司 | 对rsv具有活性的环烷基取代的吡唑并嘧啶 |
| WO2020138015A1 (ja) | 2018-12-27 | 2020-07-02 | 大正製薬株式会社 | ピラゾロ［１，５－ａ］ピリミジン大環状化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA34392B1 (fr) | 2010-06-24 | 2013-07-03 | Gilead Sciences Inc | Pyrimidines en tant qu'agents antiviraux |
| US8633198B1 (en) * | 2011-09-20 | 2014-01-21 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| CA2858096C (en) * | 2011-12-22 | 2020-06-23 | Gilead Sciences, Inc. | Pyrazolo[1,5-a]pyrimidines as antiviral agents |
| CN106986869A (zh) * | 2012-04-17 | 2017-07-28 | 吉利德科学公司 | 用于抗病毒治疗的化合物和方法 |
| AU2015359624B2 (en) | 2014-12-08 | 2020-01-02 | Janssen Sciences Ireland Uc | Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV) |
-
2015
- 2015-12-07 US US15/534,458 patent/US10131673B2/en active Active
- 2015-12-07 CA CA2963054A patent/CA2963054C/en active Active
- 2015-12-07 AU AU2015359562A patent/AU2015359562B2/en not_active Ceased
- 2015-12-07 EA EA201791276A patent/EA030636B1/ru not_active IP Right Cessation
- 2015-12-07 MX MX2017007430A patent/MX368323B/es active IP Right Grant
- 2015-12-07 CN CN201580066579.4A patent/CN107207512B/zh not_active Expired - Fee Related
- 2015-12-07 ES ES15804835T patent/ES2711334T3/es active Active
- 2015-12-07 KR KR1020177015258A patent/KR102486023B1/ko active Active
- 2015-12-07 JP JP2017529310A patent/JP6703989B2/ja not_active Expired - Fee Related
- 2015-12-07 EP EP15804835.5A patent/EP3230288B1/en active Active
- 2015-12-07 SG SG11201704508WA patent/SG11201704508WA/en unknown
- 2015-12-07 WO PCT/EP2015/078796 patent/WO2016091791A1/en not_active Ceased
-
2017
- 2017-06-07 ZA ZA2017/03900A patent/ZA201703900B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201703900B (en) | 2019-07-31 |
| AU2015359562A1 (en) | 2017-04-13 |
| CA2963054A1 (en) | 2016-06-16 |
| ES2711334T3 (es) | 2019-05-03 |
| EP3230288A1 (en) | 2017-10-18 |
| JP6703989B2 (ja) | 2020-06-03 |
| EA030636B1 (ru) | 2018-09-28 |
| KR20170094180A (ko) | 2017-08-17 |
| US20170349602A1 (en) | 2017-12-07 |
| CN107207512B (zh) | 2019-09-10 |
| AU2015359562B2 (en) | 2020-01-16 |
| CA2963054C (en) | 2023-03-14 |
| SG11201704508WA (en) | 2017-06-29 |
| US10131673B2 (en) | 2018-11-20 |
| JP2017536393A (ja) | 2017-12-07 |
| CN107207512A (zh) | 2017-09-26 |
| EA201791276A1 (ru) | 2017-09-29 |
| WO2016091791A1 (en) | 2016-06-16 |
| KR102486023B1 (ko) | 2023-01-05 |
| MX368323B (es) | 2019-09-27 |
| EP3230288B1 (en) | 2018-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |