MX2017009154A - Sintesis de un inhibidor de tirosina quinasa de bruton. - Google Patents

Sintesis de un inhibidor de tirosina quinasa de bruton.

Info

Publication number
MX2017009154A
MX2017009154A MX2017009154A MX2017009154A MX2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A
Authority
MX
Mexico
Prior art keywords
bruton
synthesis
tyrosine kinase
kinase inhibitor
inhibitor
Prior art date
Application number
MX2017009154A
Other languages
English (en)
Other versions
MX366827B (es
Inventor
Chen Wei
Goldman Erick
Benhaim Cyril
Horvath Andras
Pye Philip
S Smyth Mark
J Verner Erik
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX2017009154A publication Critical patent/MX2017009154A/es
Publication of MX366827B publication Critical patent/MX366827B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En la presente memoria se describe la síntesis de inhibidor de tirosina quinasa de Bruton (Btk) de 1-((R)-3-(4-amino-3-(4-fenoxif enil)-1H-pirazol[3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1- ona.
MX2017009154A 2015-01-14 2016-01-14 Sintesis de un inhibidor de tirosina quinasa de bruton. MX366827B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562103507P 2015-01-14 2015-01-14
PCT/US2016/013424 WO2016115356A1 (en) 2015-01-14 2016-01-14 Synthesis of a bruton's tyrosine kinase inhibitor

Publications (2)

Publication Number Publication Date
MX2017009154A true MX2017009154A (es) 2017-10-12
MX366827B MX366827B (es) 2019-07-25

Family

ID=56406389

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019008815A MX394327B (es) 2015-01-14 2016-01-14 Sintesis de un inhibidor de tirosina quinasa de bruton
MX2017009154A MX366827B (es) 2015-01-14 2016-01-14 Sintesis de un inhibidor de tirosina quinasa de bruton.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019008815A MX394327B (es) 2015-01-14 2016-01-14 Sintesis de un inhibidor de tirosina quinasa de bruton

Country Status (16)

Country Link
US (6) US20180009814A1 (es)
EP (1) EP3245208A4 (es)
JP (2) JP2018502077A (es)
KR (1) KR20170102887A (es)
CN (2) CN113816962A (es)
AU (2) AU2016206693A1 (es)
BR (1) BR112017015206B1 (es)
CA (2) CA2971460C (es)
HK (1) HK1246293A1 (es)
IL (4) IL308276A (es)
MA (1) MA41350A (es)
MX (2) MX394327B (es)
RU (1) RU2017128308A (es)
SG (2) SG10201906517VA (es)
WO (1) WO2016115356A1 (es)
ZA (1) ZA201704338B (es)

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* Cited by examiner, † Cited by third party
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WO2016127915A1 (zh) * 2015-02-12 2016-08-18 上海度德医药科技有限公司 伊布替尼的制备方法
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
EP3424505A4 (en) 2016-03-04 2019-10-16 Taiho Pharmaceutical Co., Ltd. PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS
CN109206426B (zh) * 2017-07-06 2021-10-08 上海复星星泰医药科技有限公司 吡唑并嘧啶类化合物的制备方法
JP7166331B2 (ja) 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法
CN107814804A (zh) * 2017-10-27 2018-03-20 广州科锐特生物科技有限公司 依鲁替尼的制备方法
EP4470621A3 (en) 2018-03-19 2025-05-07 Taiho Pharmaceutical Co., Ltd. Use of sodium alkyl sulfate
JP7410877B2 (ja) 2018-05-03 2024-01-10 ジュノー セラピューティクス インコーポレイテッド キメラ抗原受容体（ｃａｒ）ｔ細胞療法とキナーゼ阻害剤の併用療法
JP6944496B2 (ja) * 2018-10-22 2021-10-06 ファイザー・インク ピロロ［２，３−ｄ］ピリミジントシル酸塩、その結晶形態、ならびにその製造方法および中間体
WO2020095452A1 (ja) 2018-11-09 2020-05-14 大鵬薬品工業株式会社 ジメトキシベンゼン化合物の製造方法
CN109988175A (zh) * 2019-04-28 2019-07-09 梯尔希（南京）药物研发有限公司 一种依鲁替尼-d5的制备方法
MX2021014245A (es) * 2019-05-21 2022-01-06 Janssen Pharmaceutica Nv Procedimientos y productos intermedios para preparar un inhibidor de btk.
CA3135240A1 (en) 2019-05-21 2020-11-26 Philip James Pye Processes and intermediates for preparing a btk inhibitor
ES3031700T3 (en) 2021-01-21 2025-07-10 Synthon Bv Process for making ibrutinib
CN114853662B (zh) * 2021-02-05 2024-01-12 四川青木制药有限公司 手性肼基哌啶衍生物的制备方法
US20250302954A1 (en) 2022-05-11 2025-10-02 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2023242384A1 (en) 2022-06-17 2023-12-21 Krka, D.D., Novo Mesto Crystalline form of ibrutinib

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550214A (en) * 1981-01-05 1985-10-29 Polaroid Corporation Blocked vinyl biphenyl compounds
US4874822A (en) * 1988-04-07 1989-10-17 Minnesota Mining And Manufacturing Company Process for the acrylamidoacylation of alcohols
NZ547696A (en) * 2003-12-23 2009-12-24 Astex Therapeutics Ltd Pyrazole derivatives as protein kinase modulators
PL2526933T3 (pl) * 2006-09-22 2015-08-31 Pharmacyclics Llc Inhibitory kinazy tyrozynowej Brutona
SG10201508035TA (en) * 2007-03-28 2015-10-29 Pharmacyclics Inc Inhibitors of bruton's tyrosine kinase
US7741330B1 (en) * 2009-10-12 2010-06-22 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
BR112015001839A2 (pt) * 2012-07-30 2017-07-04 Concert Pharmaceuticals Inc ibrutinibe deuterado
CN103121999A (zh) * 2012-08-29 2013-05-29 苏州迪飞医药科技有限公司 一种酪氨酸激酶抑制剂pci-32765的合成方法
US9156847B2 (en) * 2013-03-15 2015-10-13 Janssen Pharmaceutica Nv Processes and intermediates for preparing a medicament
US8957080B2 (en) * 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN103626774B (zh) * 2013-11-20 2015-11-04 苏州明锐医药科技有限公司 伊鲁替尼的制备方法
CN105471823B (zh) * 2014-09-03 2018-10-26 阿里巴巴集团控股有限公司 一种敏感信息处理方法、装置、服务器及安全判定系统
US10266535B2 (en) * 2015-01-21 2019-04-23 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Inhibitor of FLT3 kinase and use thereof

Also Published As

Publication number Publication date
KR20170102887A (ko) 2017-09-12
CA2971460A1 (en) 2016-07-21
EP3245208A1 (en) 2017-11-22
RU2017128308A3 (es) 2019-10-24
AU2020230323A1 (en) 2020-10-01
WO2016115356A1 (en) 2016-07-21
HK1246293A1 (zh) 2018-09-07
JP2021035947A (ja) 2021-03-04
SG10201906517VA (en) 2019-08-27
US20220098200A1 (en) 2022-03-31
US20250197404A1 (en) 2025-06-19
CA3210320A1 (en) 2016-07-21
MA41350A (fr) 2017-11-21
SG11201705678YA (en) 2017-08-30
CN107108640A (zh) 2017-08-29
AU2016206693A1 (en) 2017-07-13
RU2017128308A (ru) 2019-02-14
EP3245208A4 (en) 2018-10-17
MX394327B (es) 2025-03-24
MX366827B (es) 2019-07-25
BR112017015206B1 (pt) 2023-04-11
CN113816962A (zh) 2021-12-21
IL253020A0 (en) 2017-08-31
CA2971460C (en) 2023-10-10
US20190367518A1 (en) 2019-12-05
BR112017015206A2 (pt) 2018-06-19
US20240158400A1 (en) 2024-05-16
IL308276A (en) 2024-01-01
IL322449A (en) 2025-09-01
ZA201704338B (en) 2023-10-25
MX2019008815A (es) 2019-09-26
IL274716A (en) 2020-07-30
US20200347064A1 (en) 2020-11-05
JP2018502077A (ja) 2018-01-25
US20180009814A1 (en) 2018-01-11

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