MX2017010982A - Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer. - Google Patents
Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer.Info
- Publication number
- MX2017010982A MX2017010982A MX2017010982A MX2017010982A MX2017010982A MX 2017010982 A MX2017010982 A MX 2017010982A MX 2017010982 A MX2017010982 A MX 2017010982A MX 2017010982 A MX2017010982 A MX 2017010982A MX 2017010982 A MX2017010982 A MX 2017010982A
- Authority
- MX
- Mexico
- Prior art keywords
- pridopidine
- subject
- cognitive function
- disease
- improve cognitive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Esta invención proporciona un método para mejorar la función cognitiva en un sujeto, que comprende administrar periódicamente al sujeto una cantidad de pridopidina o una sal farmacéuticamente aceptable de la misma efectiva para mejorar la función cognitiva en el sujeto. La invención también proporciona un método para tratar un sujeto que padece de enfermedad de Alzheimer, que comprende administrar periódicamente al sujeto una composición farmacéutica que comprende una cantidad de pridopidina o una sal farmacéuticamente aceptable de la misma efectiva para tratar al sujeto.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120771P | 2015-02-25 | 2015-02-25 | |
| US201562186221P | 2015-06-29 | 2015-06-29 | |
| PCT/US2016/019357 WO2016138130A1 (en) | 2015-02-25 | 2016-02-24 | Use of pridopidine to improve cognitive function and for treating alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017010982A true MX2017010982A (es) | 2017-11-20 |
| MX378579B MX378579B (es) | 2025-03-11 |
Family
ID=56689699
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017010982A MX378579B (es) | 2015-02-25 | 2016-02-24 | Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer. |
| MX2021000071A MX2021000071A (es) | 2015-02-25 | 2017-08-25 | Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021000071A MX2021000071A (es) | 2015-02-25 | 2017-08-25 | Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10603311B2 (es) |
| EP (4) | EP3261721B1 (es) |
| JP (2) | JP6887952B2 (es) |
| AU (2) | AU2016222796B2 (es) |
| CA (1) | CA2977264C (es) |
| DK (1) | DK3261721T3 (es) |
| ES (1) | ES2930628T3 (es) |
| HU (1) | HUE060353T2 (es) |
| IL (2) | IL254030B (es) |
| MX (2) | MX378579B (es) |
| PL (1) | PL3261721T3 (es) |
| TW (1) | TW201639570A (es) |
| WO (1) | WO2016138130A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012028635A1 (en) | 2010-09-03 | 2012-03-08 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
| MX347209B (es) | 2011-12-08 | 2017-04-19 | Teva Pharmaceuticals Int Gmbh | La sal de bromhidrato de pridopidina. |
| DK3010506T3 (da) | 2013-06-21 | 2021-07-12 | Prilenia Neurotherapeutics Ltd | Pridopidin i behandling af huntingtons sygdom |
| US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
| TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
| CA2970799A1 (en) | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
| US10603311B2 (en) | 2015-02-25 | 2020-03-31 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
| US11471449B2 (en) * | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
| AR105434A1 (es) | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
| JP7034488B2 (ja) | 2016-02-24 | 2022-03-14 | プリレニア・ニューロセラピューティクス・エルティーディー | プリドピジンを使用する神経変性眼疾患の治療 |
| CN110012661A (zh) | 2016-08-24 | 2019-07-12 | 普瑞尼亚医疗发展有限公司 | 普利多匹定用于治疗肌张力障碍的用途 |
| DK3504187T3 (da) * | 2016-08-24 | 2025-04-14 | Prilenia Neurotherapeutics Ltd | Anvendelse af pridopidin til behandling af funktionel tilbagegang |
| US20210093622A1 (en) * | 2016-09-15 | 2021-04-01 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for the treatment of anxiety and depression |
| ES3031271T3 (en) | 2016-09-15 | 2025-07-07 | Prilenia Neurotherapeutics Ltd | Use of pridopidine for the treatment of anxiety and depression |
| ES2986807T3 (es) * | 2016-09-16 | 2024-11-12 | Prilenia Neurotherapeutics Ltd | Pridopidina para su uso en el tratamiento del síndrome de Rett |
| US12102627B2 (en) | 2016-09-16 | 2024-10-01 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating rett syndrome |
| BR112019015000A2 (pt) * | 2017-01-20 | 2020-04-07 | Prilenia Neurotherapeutics Ltd. | uso de pridopidina para o tratamento da síndrome do x frágil |
| AU2018317346B2 (en) | 2017-08-14 | 2021-08-26 | Prilenia Neurotherapeutics Ltd. | Method of treating amyotrophic lateral sclerosis with pridopidine |
| CN111278431A (zh) | 2017-08-30 | 2020-06-12 | 普瑞尼亚神经治疗有限公司 | 普利多匹定的高浓度剂型 |
| US12036213B2 (en) | 2017-09-08 | 2024-07-16 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
| JP2020533296A (ja) | 2017-09-08 | 2020-11-19 | プリレニア ニューロセラピューティクス リミテッド | 薬物誘発性ジスキネジアを治療するためのプリドピジン |
| AU2020218158B2 (en) * | 2019-02-04 | 2023-08-03 | Prilenia Neurotherapeutics Ltd. | Low dose pridopidine for Parkinson's Disease and other diseases associated with parkinsonism |
| AU2020243692B2 (en) * | 2019-03-15 | 2023-03-02 | Prilenia Neurotherapeutics Ltd. | Treatment of mitochondrial associated diseases and disorders, including symptoms thereof using pridopidine |
| CN116059192B (zh) | 2019-11-13 | 2024-10-29 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
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| ATE201669T1 (de) | 1991-04-17 | 2001-06-15 | Upjohn Co | Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten |
| US5321012A (en) | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| SE9702716D0 (sv) * | 1997-07-15 | 1997-07-15 | Ross Nicholas Waters | Substituted phenylazacycloalkanes in the treatment of cognitive disorders |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| SE9904724D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| WO2005080976A1 (ja) * | 2004-02-20 | 2005-09-01 | Dainippon Sumitomo Pharma Co., Ltd. | 統合失調症の記憶・学習機能障害治療薬のin vivoスクリーニング方法 |
| PL1802573T3 (pl) | 2004-10-13 | 2017-03-31 | Teva Pharmaceuticals International Gmbh | Proces syntezy 4-(3-metanosulfonylofenylo)-1-N-propylopiperydyny |
| EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
| CN101711236B (zh) | 2007-04-12 | 2012-10-31 | Nsab神经研究瑞典公司分公司 | 表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物 |
| EP2254564A1 (en) * | 2007-12-12 | 2010-12-01 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| ES2612948T3 (es) | 2009-04-23 | 2017-05-19 | Universität Zürich | Bloqueantes del receptor de NMDA para el tratamiento de anemia falciforme |
| EP2322163A1 (en) * | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| US8849866B2 (en) | 2010-02-22 | 2014-09-30 | Infosys Limited | Method and computer program product for creating ordered data structure |
| WO2011107583A1 (en) | 2010-03-04 | 2011-09-09 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders |
| US9000047B2 (en) | 2010-05-24 | 2015-04-07 | Farmalider, S.A. | Compound inhibiting activation of the enzyme Erk 1/2 to be used in the treatment of neurodegenerative illnesses |
| WO2012028635A1 (en) | 2010-09-03 | 2012-03-08 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
| UY34278A (es) | 2011-08-25 | 2013-04-05 | Novartis Ag | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
| CN103958469B (zh) | 2011-09-07 | 2016-04-20 | 梯瓦制药国际有限责任公司 | 一种新的普利多匹定盐酸盐多晶型形态 |
| MX347209B (es) | 2011-12-08 | 2017-04-19 | Teva Pharmaceuticals Int Gmbh | La sal de bromhidrato de pridopidina. |
| AU2013243461A1 (en) | 2012-04-04 | 2014-11-06 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for combination therapy |
| US20140088145A1 (en) * | 2012-09-27 | 2014-03-27 | Teva Pharmaceutical Industries, Ltd. | Combination of rasagiline and pridopidine for treating neurodegenerative disorders, in particular huntington's disease |
| WO2014052933A1 (en) | 2012-09-27 | 2014-04-03 | Teva Pharmaceutical Industries Ltd. | Laquinimod and pridopidine for treating neurodegenerative disorders |
| DK3004080T3 (da) | 2013-06-04 | 2019-01-02 | Acturum Real Estate Ab | Triazolforbindelser og deres anvendelse som gamma-sekretase-modulatorer |
| DK3010506T3 (da) * | 2013-06-21 | 2021-07-12 | Prilenia Neurotherapeutics Ltd | Pridopidin i behandling af huntingtons sygdom |
| EA201691454A1 (ru) | 2014-01-22 | 2017-01-30 | Тева Фармасьютикалз Интернэшнл Гмбх | Композиции придопидина модифицированного высвобождения |
| TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
| CA2970799A1 (en) | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
| US10603311B2 (en) | 2015-02-25 | 2020-03-31 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
| WO2016138135A1 (en) | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Sigma-1 receptor modulators for treating huntington's disease |
| US20170020854A1 (en) | 2015-07-22 | 2017-01-26 | Teva Pharmaceuticals International Gmbh | Pridopidine base formulations and their use |
| AR105434A1 (es) | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
| WO2017048457A1 (en) | 2015-09-18 | 2017-03-23 | Teva Pharmaceuticals Industries Ltd. | Combination of laquinimod and pridopidine to treat multiple sclerosis |
| CN110012661A (zh) | 2016-08-24 | 2019-07-12 | 普瑞尼亚医疗发展有限公司 | 普利多匹定用于治疗肌张力障碍的用途 |
| DK3504187T3 (da) | 2016-08-24 | 2025-04-14 | Prilenia Neurotherapeutics Ltd | Anvendelse af pridopidin til behandling af funktionel tilbagegang |
-
2016
- 2016-02-24 US US15/052,368 patent/US10603311B2/en active Active
- 2016-02-24 EP EP16756274.3A patent/EP3261721B1/en active Active
- 2016-02-24 EP EP21153340.1A patent/EP3854785A1/en not_active Ceased
- 2016-02-24 ES ES16756274T patent/ES2930628T3/es active Active
- 2016-02-24 MX MX2017010982A patent/MX378579B/es unknown
- 2016-02-24 WO PCT/US2016/019357 patent/WO2016138130A1/en not_active Ceased
- 2016-02-24 CA CA2977264A patent/CA2977264C/en active Active
- 2016-02-24 HU HUE16756274A patent/HUE060353T2/hu unknown
- 2016-02-24 EP EP19191835.8A patent/EP3590512A1/en not_active Withdrawn
- 2016-02-24 EP EP23198399.0A patent/EP4282479A3/en not_active Withdrawn
- 2016-02-24 PL PL16756274.3T patent/PL3261721T3/pl unknown
- 2016-02-24 JP JP2017545405A patent/JP6887952B2/ja active Active
- 2016-02-24 AU AU2016222796A patent/AU2016222796B2/en active Active
- 2016-02-24 DK DK16756274.3T patent/DK3261721T3/da active
- 2016-02-25 TW TW105105721A patent/TW201639570A/zh unknown
-
2017
- 2017-08-16 IL IL254030A patent/IL254030B/en unknown
- 2017-08-25 MX MX2021000071A patent/MX2021000071A/es unknown
-
2021
- 2021-01-07 JP JP2021001418A patent/JP7210620B2/ja active Active
- 2021-03-12 AU AU2021201583A patent/AU2021201583B2/en active Active
- 2021-09-30 IL IL286888A patent/IL286888A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7210620B2 (ja) | 2023-01-23 |
| ES2930628T3 (es) | 2022-12-20 |
| AU2021201583B2 (en) | 2022-04-07 |
| EP3261721A1 (en) | 2018-01-03 |
| CA2977264C (en) | 2021-12-07 |
| MX378579B (es) | 2025-03-11 |
| PL3261721T3 (pl) | 2022-12-27 |
| TW201639570A (zh) | 2016-11-16 |
| EP4282479A3 (en) | 2024-02-21 |
| AU2016222796A1 (en) | 2017-10-05 |
| IL254030B (en) | 2022-01-01 |
| AU2016222796B2 (en) | 2021-07-15 |
| EP3590512A1 (en) | 2020-01-08 |
| WO2016138130A1 (en) | 2016-09-01 |
| DK3261721T3 (da) | 2022-11-28 |
| HUE060353T2 (hu) | 2023-02-28 |
| IL254030A0 (en) | 2017-10-31 |
| AU2021201583A1 (en) | 2021-04-01 |
| CA2977264A1 (en) | 2016-09-01 |
| IL286888A (en) | 2021-10-31 |
| EP3261721B1 (en) | 2022-09-14 |
| US10603311B2 (en) | 2020-03-31 |
| EP4282479A2 (en) | 2023-11-29 |
| JP2018506569A (ja) | 2018-03-08 |
| JP6887952B2 (ja) | 2021-06-16 |
| MX2021000071A (es) | 2021-03-25 |
| EP3261721A4 (en) | 2018-08-08 |
| US20160243098A1 (en) | 2016-08-25 |
| EP3854785A1 (en) | 2021-07-28 |
| JP2021073206A (ja) | 2021-05-13 |
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