MX2017011910A - Métodos, herramientas y sistemas para la evaluación, prevención, manejo y selección de tratamiento para diabetes tipo 2. - Google Patents
Métodos, herramientas y sistemas para la evaluación, prevención, manejo y selección de tratamiento para diabetes tipo 2.Info
- Publication number
- MX2017011910A MX2017011910A MX2017011910A MX2017011910A MX2017011910A MX 2017011910 A MX2017011910 A MX 2017011910A MX 2017011910 A MX2017011910 A MX 2017011910A MX 2017011910 A MX2017011910 A MX 2017011910A MX 2017011910 A MX2017011910 A MX 2017011910A
- Authority
- MX
- Mexico
- Prior art keywords
- type
- diabetes
- treatment
- snp
- tools
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 3
- 238000011156 evaluation Methods 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 108700028369 Alleles Proteins 0.000 abstract 1
- 102000009508 Cyclin-Dependent Kinase Inhibitor p16 Human genes 0.000 abstract 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 abstract 1
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 abstract 1
- 101000614701 Homo sapiens ATP-sensitive inward rectifier potassium channel 11 Proteins 0.000 abstract 1
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 abstract 1
- 101000599779 Homo sapiens Insulin-like growth factor 2 mRNA-binding protein 2 Proteins 0.000 abstract 1
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 abstract 1
- 101000741790 Homo sapiens Peroxisome proliferator-activated receptor gamma Proteins 0.000 abstract 1
- 101000737828 Homo sapiens Threonylcarbamoyladenosine tRNA methylthiotransferase Proteins 0.000 abstract 1
- 101000596771 Homo sapiens Transcription factor 7-like 2 Proteins 0.000 abstract 1
- 102100037919 Insulin-like growth factor 2 mRNA-binding protein 2 Human genes 0.000 abstract 1
- 102100025947 Insulin-like growth factor II Human genes 0.000 abstract 1
- 102000017792 KCNJ11 Human genes 0.000 abstract 1
- 108010011185 KCNQ1 Potassium Channel Proteins 0.000 abstract 1
- 102100021445 Monocarboxylate transporter 11 Human genes 0.000 abstract 1
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 abstract 1
- 102100037444 Potassium voltage-gated channel subfamily KQT member 1 Human genes 0.000 abstract 1
- 108091006609 SLC16A11 Proteins 0.000 abstract 1
- 108091006556 SLC30A8 Proteins 0.000 abstract 1
- 102100035310 Threonylcarbamoyladenosine tRNA methylthiotransferase Human genes 0.000 abstract 1
- 102100035101 Transcription factor 7-like 2 Human genes 0.000 abstract 1
- 238000003205 genotyping method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000012502 risk assessment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención provee un método para evaluar la susceptibilidad a la diabetes tipo 2 y/o predecir la respuesta al tratamiento en un sujeto humano, el que comprende determinar la identidad de al menos un alelo en cada una de tres o más posiciones de polimorfismo de nucleótido simple (SNP) seleccionadas del grupo que consiste en: SLC16A11 - rs75493593, HNF1A - rs483353044; TCF7L2 - rs7903146, CDKN2A/B - rs10811661, CDKAL1 - rs7756992, SLC30A8 - rs3802177, IGF2BP2 - rs4402960, FTO - rs9936385, PPARG - rs1801282, HHEX/IDE - rs1111875, ADCY5 - rs11717195, JAZF1 - rs849135, WSF1 - rs4458523, INS-IGF2 - rs149483638, KCNQ1 - rs2237897 y KCNJ11 - rs5219, y/o un SNP con desequilibrio de enlace con cualquiera de dichos SNP a r2>0.8. También se proveen una herramienta de genotipado y un sistema de evaluación de riesgo de diabetes tipo 2 a utilizar en el método de la invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1504607.1A GB201504607D0 (en) | 2015-03-18 | 2015-03-18 | Methods,tools and systems for the assessment,preventation,management and treatment selection for type 2 diabetes |
| PCT/EP2016/055949 WO2016146811A1 (en) | 2015-03-18 | 2016-03-18 | Methods, tools and systems for the assessment, prevention, management and treatment selection for type 2 diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017011910A true MX2017011910A (es) | 2018-08-28 |
| MX377264B MX377264B (es) | 2025-03-07 |
Family
ID=53052023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017011910A MX377264B (es) | 2015-03-18 | 2016-03-18 | Métodos, herramientas y sistemas para la evaluación, prevención, manejo y selección de tratamiento para diabetes tipo 2. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20180094318A1 (es) |
| EP (1) | EP3271476B1 (es) |
| JP (1) | JP6751418B2 (es) |
| DK (1) | DK3271476T3 (es) |
| ES (1) | ES2794950T3 (es) |
| GB (1) | GB201504607D0 (es) |
| MX (1) | MX377264B (es) |
| WO (1) | WO2016146811A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019104146A1 (en) | 2017-11-22 | 2019-05-31 | Mayo Foundation For Medical Education And Research | Methods and materials for assessing and treating obesity |
| AU2019284248A1 (en) * | 2018-06-15 | 2021-01-07 | Les Laboratoires Servier | Polygenic risk scores for predicting disease complications and/or response to therapy |
| JP6688418B1 (ja) * | 2019-04-16 | 2020-04-28 | ジェネシスヘルスケア株式会社 | ２型糖尿病のリスクを判定する方法 |
| WO2021170504A1 (en) * | 2020-02-25 | 2021-09-02 | Ling Charlotte | Dna methylation level of specific cpg sites for prediction of glycemic response and tolerance to metformin treatment in type 2 diabetic patients |
| CA3220596A1 (en) * | 2021-05-21 | 2022-11-24 | Mayo Foundation For Medical Education And Research | Assessing and treating obesity |
| CN113393896A (zh) * | 2021-06-11 | 2021-09-14 | 成都果壳医学科技有限公司 | 一种基于深度神经网络的i型糖尿病风险评估系统 |
| WO2023077236A1 (en) * | 2021-11-04 | 2023-05-11 | Scimar Ltd. | Methods and kits for determining insulin resistance treatment |
| CN120019166A (zh) * | 2022-10-12 | 2025-05-16 | 首尔大学医院 | 利用thada标记物的用于预测磺酰脲类依赖性的组合物及其预测方法 |
| KR102679905B1 (ko) | 2022-10-12 | 2024-07-02 | 서울대학교병원 | Gipr 마커를 이용한 설폰요소제 의존성 예측용 조성물 및 그 예측 방법 |
| WO2025084481A1 (ko) * | 2023-10-20 | 2025-04-24 | (주)아이크로진 | 비만과 제2형 당뇨병 관련 유전 변이를 고려한 제2형 당뇨병의 유전적 고위험군을 선별하는 방법 |
| WO2025211477A1 (ko) * | 2024-04-03 | 2025-10-09 | 서울대학교병원 | 유전자 마커를 이용한 설폰요소제 의존성 예측용 조성물 및 그 예측 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6210272B1 (en) * | 1997-12-22 | 2001-04-03 | Health Hero Network, Inc. | Multi-player interactive electronic game for health education |
| JP5033392B2 (ja) * | 2006-03-10 | 2012-09-26 | 国立大学法人三重大学 | ２型糖尿病の遺伝的リスク検出法 |
| US20090307180A1 (en) | 2008-03-19 | 2009-12-10 | Brandon Colby | Genetic analysis |
| CN102177252B (zh) * | 2008-08-12 | 2014-12-24 | 解码遗传学私营有限责任公司 | 用于甲状腺癌症的风险评估的遗传变型 |
| AU2010269841A1 (en) * | 2009-07-10 | 2012-02-23 | Decode Genetics Ehf | Genetic markers associated with risk of diabetes mellitus |
-
2015
- 2015-03-18 GB GBGB1504607.1A patent/GB201504607D0/en not_active Ceased
-
2016
- 2016-03-18 DK DK16710971.9T patent/DK3271476T3/da active
- 2016-03-18 MX MX2017011910A patent/MX377264B/es active IP Right Grant
- 2016-03-18 ES ES16710971T patent/ES2794950T3/es active Active
- 2016-03-18 US US15/559,236 patent/US20180094318A1/en not_active Abandoned
- 2016-03-18 WO PCT/EP2016/055949 patent/WO2016146811A1/en not_active Ceased
- 2016-03-18 EP EP16710971.9A patent/EP3271476B1/en active Active
- 2016-03-18 JP JP2017567545A patent/JP6751418B2/ja active Active
-
2020
- 2020-04-28 US US16/860,505 patent/US11578368B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX377264B (es) | 2025-03-07 |
| US20180094318A1 (en) | 2018-04-05 |
| US11578368B2 (en) | 2023-02-14 |
| WO2016146811A1 (en) | 2016-09-22 |
| JP2018515128A (ja) | 2018-06-14 |
| US20200318192A1 (en) | 2020-10-08 |
| JP6751418B2 (ja) | 2020-09-09 |
| EP3271476B1 (en) | 2020-03-04 |
| DK3271476T3 (da) | 2020-06-08 |
| GB201504607D0 (en) | 2015-05-06 |
| ES2794950T3 (es) | 2020-11-19 |
| EP3271476A1 (en) | 2018-01-24 |
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