MX2018014165A - Compuestos heterociclicos utiles como agentes antibacterianos y metodo de produccion. - Google Patents
Compuestos heterociclicos utiles como agentes antibacterianos y metodo de produccion.Info
- Publication number
- MX2018014165A MX2018014165A MX2018014165A MX2018014165A MX2018014165A MX 2018014165 A MX2018014165 A MX 2018014165A MX 2018014165 A MX2018014165 A MX 2018014165A MX 2018014165 A MX2018014165 A MX 2018014165A MX 2018014165 A MX2018014165 A MX 2018014165A
- Authority
- MX
- Mexico
- Prior art keywords
- production
- heterocyclic compounds
- compounds useful
- bacterial agents
- medicaments
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- -1 complexes Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente divulgación se refiere a compuestos de Fórmula I, a sus estereoisómeros, sales farmacéuticamente aceptables, complejos, hidratos, solvatos, tautómeros, polimorfos, mezclas racémicas, formas ópticamente activas y derivados farmacéuticamente activos y a composiciones farmacéuticas que los contienen como ingrediente activo, que se pueden utilizar como medicamentos. Las sustancias antes mencionadas también se pueden utilizar en la fabricación de medicamentos para el tratamiento, la prevención o supresión de enfermedades, y afecciones mediadas por microbios. La presente divulgación se refiere también a la síntesis y caracterización de las sustancias antes mencionadas. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201641017526 | 2016-05-20 | ||
| PCT/IN2017/050188 WO2017199265A1 (en) | 2016-05-20 | 2017-05-19 | Heterocyclic compounds useful as anti-bacterial agents and method for production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014165A true MX2018014165A (es) | 2019-08-21 |
Family
ID=57139944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014165A MX2018014165A (es) | 2016-05-20 | 2017-05-19 | Compuestos heterociclicos utiles como agentes antibacterianos y metodo de produccion. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10711011B2 (es) |
| EP (1) | EP3458452B1 (es) |
| JP (1) | JP6671541B2 (es) |
| KR (1) | KR20190034154A (es) |
| CN (1) | CN109476652B (es) |
| AU (1) | AU2017267631A1 (es) |
| BR (1) | BR112018073743A2 (es) |
| CA (1) | CA3024824A1 (es) |
| GB (1) | GB2550437B (es) |
| MX (1) | MX2018014165A (es) |
| RU (1) | RU2018142830A (es) |
| WO (1) | WO2017199265A1 (es) |
| ZA (1) | ZA201808531B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| US10912780B2 (en) | 2017-06-08 | 2021-02-09 | Bugworks Research, Inc. | Heterocyclic compounds useful as anti-bacterial agents and method for production thereof |
| JP7473204B2 (ja) * | 2018-03-28 | 2024-04-23 | バグワークス・リサーチ・インコーポレイテッド | オキサゾリジノン抗生物質化合物及び調製方法 |
| MX2023010065A (es) * | 2021-03-02 | 2023-11-17 | Recursion Pharmaceuticals Inc | Derivados de diazepina utiles en el tratamiento de clostridium difficile. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU52403A (sh) * | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| EP2004640A1 (en) * | 2006-02-08 | 2008-12-24 | Pfizer Products Inc. | Oxazolidinones containing oxindoles as antibacterial agents |
| ES2331930T3 (es) * | 2006-02-14 | 2010-01-20 | Pfizer Products Inc. | Oxazolidinonas con benzoxazinonas y benzoxazepinonas como agentes antibacterianos. |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| ES2395491T3 (es) * | 2008-10-10 | 2013-02-13 | Actelion Pharmaceuticals Ltd. | 2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos |
| IN2014CN04174A (es) * | 2011-12-22 | 2015-09-04 | Novartis Ag | |
| MA38588B1 (fr) * | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés bi-aromatiques antibactériens |
| AR102256A1 (es) * | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| GB2550437B (en) | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
-
2016
- 2016-09-01 GB GB1614801.7A patent/GB2550437B/en active Active
-
2017
- 2017-05-19 EP EP17737888.2A patent/EP3458452B1/en active Active
- 2017-05-19 CN CN201780029570.5A patent/CN109476652B/zh active Active
- 2017-05-19 AU AU2017267631A patent/AU2017267631A1/en not_active Abandoned
- 2017-05-19 WO PCT/IN2017/050188 patent/WO2017199265A1/en not_active Ceased
- 2017-05-19 JP JP2019513506A patent/JP6671541B2/ja active Active
- 2017-05-19 CA CA3024824A patent/CA3024824A1/en not_active Abandoned
- 2017-05-19 MX MX2018014165A patent/MX2018014165A/es unknown
- 2017-05-19 RU RU2018142830A patent/RU2018142830A/ru not_active Application Discontinuation
- 2017-05-19 US US16/301,887 patent/US10711011B2/en active Active
- 2017-05-19 KR KR1020187036214A patent/KR20190034154A/ko not_active Ceased
- 2017-05-19 BR BR112018073743-7A patent/BR112018073743A2/pt not_active IP Right Cessation
-
2018
- 2018-12-18 ZA ZA2018/08531A patent/ZA201808531B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2550437B (en) | 2021-06-23 |
| CN109476652B (zh) | 2022-07-15 |
| RU2018142830A3 (es) | 2020-06-22 |
| BR112018073743A2 (pt) | 2019-02-26 |
| JP2019519605A (ja) | 2019-07-11 |
| WO2017199265A1 (en) | 2017-11-23 |
| US20190292199A1 (en) | 2019-09-26 |
| EP3458452B1 (en) | 2023-08-30 |
| GB2550437A (en) | 2017-11-22 |
| ZA201808531B (en) | 2020-02-26 |
| CN109476652A (zh) | 2019-03-15 |
| CA3024824A1 (en) | 2017-11-23 |
| AU2017267631A1 (en) | 2018-12-06 |
| GB201614801D0 (en) | 2016-10-19 |
| EP3458452A1 (en) | 2019-03-27 |
| JP6671541B2 (ja) | 2020-03-25 |
| KR20190034154A (ko) | 2019-04-01 |
| US10711011B2 (en) | 2020-07-14 |
| RU2018142830A (ru) | 2020-06-22 |
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