MX2019011995A - Generación de una suspensión fría en un punto de suministro. - Google Patents

Generación de una suspensión fría en un punto de suministro.

Info

Publication number
MX2019011995A
MX2019011995A MX2019011995A MX2019011995A MX2019011995A MX 2019011995 A MX2019011995 A MX 2019011995A MX 2019011995 A MX2019011995 A MX 2019011995A MX 2019011995 A MX2019011995 A MX 2019011995A MX 2019011995 A MX2019011995 A MX 2019011995A
Authority
MX
Mexico
Prior art keywords
point
cold slurry
delivery
slurry generation
delivery cold
Prior art date
Application number
MX2019011995A
Other languages
English (en)
Inventor
J P Velis Christopher
Original Assignee
Miraki Innovation Think Tank Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miraki Innovation Think Tank Llc filed Critical Miraki Innovation Think Tank Llc
Publication of MX2019011995A publication Critical patent/MX2019011995A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F7/123—Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/0085—Devices for generating hot or cold treatment fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00—Local anaesthesia; Hypothermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • A61F2007/0057—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling of gas, e.g. air or carbon dioxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0095—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0282—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects
    • A61F2007/0287—Preventing negative effects of chemotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0282—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects
    • A61F2007/0288—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects during operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0282—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects
    • A61F2007/029—Fat cell removal or destruction by non-ablative heat treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • A61F2007/101—Cooling bags, e.g. ice-bags for cooling organs in the body before or during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1011—Multiple balloon catheters
    • A61M2025/1013—Multiple balloon catheters with concentrically mounted balloons, e.g. being independently inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/362—General characteristics of the apparatus related to heating or cooling by gas flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1011—Multiple balloon catheters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Confectionery (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
  • Paper (AREA)

Abstract

La presente invención proporciona métodos y dispositivos para preparar una suspensión fría en un punto de suministro; un dispositivo de punto de suministro suministra componentes de suspensión fría a una ubicación en o cerca del tejido objetivo; los componentes son combinados para preparar la suspensión fría en o cerca del punto de suministro; este enfoque degenerar una suspensión fría en el punto de suministro permite mantener y controlar las características de la suspensión fría, tal como temperatura, forma de partícula y tamaño de partícula.
MX2019011995A 2017-04-05 2018-04-05 Generación de una suspensión fría en un punto de suministro. MX2019011995A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762482003P 2017-04-05 2017-04-05
PCT/US2018/026260 WO2018187573A1 (en) 2017-04-05 2018-04-05 Point of delivery cold slurry generation

Publications (1)

Publication Number Publication Date
MX2019011995A true MX2019011995A (es) 2020-01-20

Family

ID=63710039

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011995A MX2019011995A (es) 2017-04-05 2018-04-05 Generación de una suspensión fría en un punto de suministro.

Country Status (13)

Country Link
US (1) US11439532B2 (es)
EP (1) EP3606482A4 (es)
JP (2) JP2020516357A (es)
KR (1) KR20200017385A (es)
CN (1) CN110868968A (es)
AU (1) AU2018250270A1 (es)
BR (1) BR112019020971A8 (es)
CA (1) CA3059294A1 (es)
IL (1) IL269857A (es)
MX (1) MX2019011995A (es)
SG (1) SG11201909303TA (es)
WO (1) WO2018187573A1 (es)
ZA (1) ZA201907138B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2667811B1 (en) 2011-01-27 2015-12-30 Cryosa, Llc Apparatus for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
WO2016033384A1 (en) 2014-08-28 2016-03-03 The General Hospital Corporation Injectable slurries and methods of manufacturing and using the same
US11534335B2 (en) 2014-10-01 2022-12-27 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
AU2018249540A1 (en) 2017-04-05 2019-10-31 Miraki Innovation Think Tank Llc Cold slurry containment
MX2019011995A (es) 2017-04-05 2020-01-20 Miraki Innovation Think Tank Llc Generación de una suspensión fría en un punto de suministro.
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
WO2020077072A1 (en) * 2018-10-12 2020-04-16 Miraki Innovation Think Tank Llc Cold solution for fat reduction
JP2022520156A (ja) 2018-12-31 2022-03-29 クライオサ， インク． 閉塞性睡眠時無呼吸の処置の為のシステム及び方法
JP2023508941A (ja) * 2019-12-24 2023-03-06 ミラキ イノベーション シンク タンク エルエルシー 実質的に固体の溶液、実質的に固体の溶液を生成するシステム及び方法、並びにそれを投与する方法
US12551259B2 (en) 2020-02-19 2026-02-17 Cryosa, Inc. Systems and methods for treatment of obstructive sleep apnea
WO2021247843A1 (en) * 2020-06-05 2021-12-09 Miraki Innovation Think Tank Llc Systems for reducing fat and improving the appearance of skin using multiple modalities
AU2021305336B2 (en) 2020-07-10 2025-02-06 C° Change Surgical Llc Injectable slush feed supply
US20220071900A1 (en) * 2020-09-08 2022-03-10 Brixton Biosciences, Inc. Systems and methods for preparing and transporting an injectable slurry
US11241330B1 (en) 2021-04-02 2022-02-08 Brixton Biosciences, Inc. Apparatus for creation of injectable slurry
WO2023130069A2 (en) 2021-12-30 2023-07-06 Cryosa, Inc. Systems and methods for treatment of obstructive sleep apnea

Family Cites Families (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3373906A (en) 1967-02-10 1968-03-19 Haart Inc De Syringe with stirrer
US3893834A (en) 1974-03-04 1975-07-08 Arthur E Armstrong Insulated cold pack
US4619678A (en) 1983-12-20 1986-10-28 Howard Rubin Apparatus and method for transporting and preserving perishable test samples
US4983045A (en) 1985-11-22 1991-01-08 Reica Corporation Mixer
DE3609672A1 (de) 1986-03-21 1987-09-24 Klaus Draenert Evakuierbare knochenzementspritze
US5143063A (en) 1988-02-09 1992-09-01 Fellner Donald G Method of removing adipose tissue from the body
JP2512095B2 (ja) 1988-08-12 1996-07-03 株式会社日立製作所 冷熱発生方法
EP0418979A3 (en) 1989-09-21 1992-03-04 Michele Dr. Zocchi Method and apparatus for producing human autologous collagen
US5071040A (en) 1990-03-09 1991-12-10 Pfizer Hospital Products Group, Inc. Surgical adhesives mixing and dispensing implement
US5304128A (en) 1992-09-22 1994-04-19 Habley Medical Technology Corporation Gas powered self contained syringe
US5445523A (en) 1993-09-03 1995-08-29 Ultradent Products, Inc. Syringe apparatus and methods for dispensing viscous materials
US5507790A (en) 1994-03-21 1996-04-16 Weiss; William V. Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism
US5769879A (en) 1995-06-07 1998-06-23 Medical Contouring Corporation Microwave applicator and method of operation
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
HUP0000355A3 (en) 1996-10-23 2001-03-28 Wolsey Henry Garnet Haverfordw Cooling pouch
US5910104A (en) 1996-12-26 1999-06-08 Cryogen, Inc. Cryosurgical probe with disposable sheath
AU6865298A (en) 1997-03-17 1998-10-12 Boris Rubinsky The use of cryoprotective agent compounds during cryosurgery
US6032675A (en) 1997-03-17 2000-03-07 Rubinsky; Boris Freezing method for controlled removal of fatty tissue by liposuction
GB2338428A (en) 1998-06-19 1999-12-22 David Grant A syringe with an agitator whose shaft passes through a slidable dispensing plunger
US6458109B1 (en) 1998-08-07 2002-10-01 Hill-Rom Services, Inc. Wound treatment apparatus
US6428563B1 (en) 2000-01-21 2002-08-06 Radiant Medical, Inc. Heat exchange catheter with improved insulated region
US6403376B1 (en) 1998-11-16 2002-06-11 General Hospital Corporation Ultra rapid freezing for cell cryopreservation
US6300130B1 (en) 1998-11-16 2001-10-09 The General Hospital Corporation And University Of Massachusetts Ultra rapid freezing for cell cryopreservation
US6324863B1 (en) 1999-03-05 2001-12-04 Imi Cornelius Inc. Sanitary ice making system
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US6334328B1 (en) 1999-03-12 2002-01-01 Imi Cornelius Inc. Sanitary ice making and dispensing apparatus
JP3111219B1 (ja) 1999-05-25 2000-11-20 工業技術院長 ポリビニルアルコールを利用した冷熱輸送方法及び装置
EP1216002A4 (en) 1999-05-25 2003-02-12 Douglas O Chinn Cryosonde with insulating and heated jacket
WO2001008593A2 (en) 1999-08-02 2001-02-08 Becker Lance B Method for inducing hypothermia
US6962601B2 (en) 1999-08-02 2005-11-08 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6413444B1 (en) 1999-08-02 2002-07-02 The University Of Chicago Methods and apparatus for producing phase change ice particulate saline slurries
US7422601B2 (en) 1999-08-02 2008-09-09 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6244052B1 (en) 1999-08-02 2001-06-12 The University Of Chicago Method and apparatus for producing phase change ice particulate perfluorocarbon slurries
AU6519100A (en) 1999-08-05 2001-03-05 Biocardia, Inc. A system and method for delivering thermally sensitive and reverse-thermal gelation matrials
US6231594B1 (en) 1999-08-11 2001-05-15 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
DE59904983D1 (de) 1999-12-23 2003-05-15 Muehlbauer Ernst Gmbh & Co Kg Dynamischer Mischer für zahnärztliche Abdruckmassen
US20040220559A1 (en) 2000-03-01 2004-11-04 Kramer Hans W. Preparation of working fluid for use in cryotherapies
WO2001076517A2 (en) 2000-04-07 2001-10-18 The General Hospital Corporation D/B/A Massachusetts General Hospital Methods and apparatus for thermally affecting tissue
US20020045156A1 (en) 2000-05-16 2002-04-18 Mehmet Toner Microinjection of cryoprotectants for preservation of cells
US7255865B2 (en) 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
EP1384036B1 (en) 2001-03-27 2005-01-26 Skaginn HF A method and apparatus for producing fluid ice
US6547432B2 (en) 2001-07-16 2003-04-15 Stryker Instruments Bone cement mixing and delivery device for injection and method thereof
US20030032996A1 (en) 2001-08-08 2003-02-13 Hallman Arlan Jay Cryogenic massage tube and compress
US6571564B2 (en) 2001-10-23 2003-06-03 Shashank Upadhye Timed container warmer and cooler
US20040092920A1 (en) 2001-12-20 2004-05-13 Eyal Rozenshpeer Cutting and removal of biologic tissue by pressurized propulsion of ice particles
CH695758A5 (de) 2002-03-05 2006-08-31 Tecpharma Licensing Ag Kühlvorrichtung für Injektionsgeräte.
SI2241295T1 (sl) 2002-03-15 2012-11-30 Gen Hospital Corp Naprave za selektivno razbitje maščobnega tkivaz nadzorovanim hlajenjem
US8840608B2 (en) 2002-03-15 2014-09-23 The General Hospital Corporation Methods and devices for selective disruption of fatty tissue by controlled cooling
CA2760543C (en) 2002-09-12 2013-08-13 Zoll Circulation, Inc. System and method for determining and controlling core body temperature
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7118591B2 (en) 2003-04-17 2006-10-10 The University Of Chicago Heat transfer probe
JP3702295B1 (ja) * 2004-03-31 2005-10-05 国立大学法人 岡山大学 脳の冷却装置及びこれに用いる流体注入装置
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US20060036302A1 (en) 2004-05-28 2006-02-16 Kasza Kenneth E Methods of inducing protective hypothermia of organs
EP1812605A4 (en) 2004-11-05 2012-04-25 Life Technologies Corp COMPOSITIONS AND METHODS FOR USING HIGH FREQUENCY IDENTIFIERS FOR LIFE SCIENCES
US20060161232A1 (en) 2005-01-18 2006-07-20 Kasza, Oras and Son to The University of Chicago Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices
AU2006213885A1 (en) 2005-02-09 2006-08-17 Children's Medical Center Corporation Device for mixing and delivering fluids for tissue repair
US20060190066A1 (en) 2005-02-23 2006-08-24 Worthen William J System and method for bringing hypothermia rapidly onboard
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
CA2737845A1 (en) 2005-08-22 2007-03-01 Kieran P. Murphy Bone augmentation apparatus
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US7389653B2 (en) 2005-09-15 2008-06-24 The University Of Chicago Medical ice slurry production device
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US7681411B2 (en) 2006-01-17 2010-03-23 Dilorenzo Thomas Ice making and dispensing method and apparatus with increased sanitation
US20080045880A1 (en) 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
US7854754B2 (en) 2006-02-22 2010-12-21 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
US8147453B2 (en) 2006-03-13 2012-04-03 Applied Medical Resources Corporation Balloon trocar
JP4703724B2 (ja) 2006-04-28 2011-06-15 ゼルティック エステティックス インコーポレイテッド 皮下の脂質リッチ細胞の冷却が改善された治療装置に使用する凍結防止剤
US20070270925A1 (en) 2006-05-17 2007-11-22 Juniper Medical, Inc. Method and apparatus for non-invasively removing heat from subcutaneous lipid-rich cells including a coolant having a phase transition temperature
WO2007147060A2 (en) 2006-06-14 2007-12-21 Voyage Medical, Inc. Visualization apparatus and methods for transseptal access
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US20080077201A1 (en) 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling devices with flexible sensors
EP2088950A2 (en) 2006-10-31 2009-08-19 Zeltiq Aesthetics, Inc. Method and apparatus for cooling subcutaneous lipid-rich cells or tissue
US8382704B2 (en) 2006-12-29 2013-02-26 Medrad, Inc. Systems and methods of delivering a dilated slurry to a patient
US7699803B2 (en) 2007-01-03 2010-04-20 Medtronic Vascular, Inc. Devices and methods for injection of multiple-component therapies
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
US8096975B2 (en) 2007-05-29 2012-01-17 Lewis Van L Injector and thermal jacket for use with same
US20090018625A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. Managing system temperature to remove heat from lipid-rich regions
US20090018626A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. User interfaces for a system that removes heat from lipid-rich regions
US20090018624A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. Limiting use of disposable system patient protection devices
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US20090018627A1 (en) 2007-07-13 2009-01-15 Juniper Medical, Inc. Secure systems for removing heat from lipid-rich regions
US7740612B2 (en) 2007-07-27 2010-06-22 Milestone Scientific, Inc Self-administration injection system
US9044212B2 (en) 2007-07-30 2015-06-02 Nuvue Therapeutics, Inc. Fluid flowing device and method for tissue diagnosis or therapy
EP3488833B1 (en) 2007-08-21 2025-10-22 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
JP2011502237A (ja) 2007-10-19 2011-01-20 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 二相冷却剤の生成及びその冷却能力の決定のためのシステム及び方法
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
US8128605B2 (en) 2007-12-24 2012-03-06 Mentor Worldwide Llc Syringe for use in medical applications
WO2009086399A2 (en) 2007-12-28 2009-07-09 3M Innovative Properties Company Therapy device
WO2009089090A2 (en) 2008-01-03 2009-07-16 Vertos Medical, Inc. Thermally regulated hypodermic needles, methods of use, and kits
US8505315B2 (en) * 2008-04-15 2013-08-13 Uchicago Argonne, Llc Enhanced integrated operation blender based sterile medical ice slurry production device
US8535275B2 (en) 2008-06-26 2013-09-17 Bellanovus Development Company Llc Syringe-attached topical anesthetic dispenser
WO2010017477A2 (en) 2008-08-07 2010-02-11 The General Hospital Corporation Method and apparatus for dermatological hypopigmentation
WO2010017556A1 (en) 2008-08-08 2010-02-11 Palomar Medical Technologies, Inc Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue
US8275442B2 (en) 2008-09-25 2012-09-25 Zeltiq Aesthetics, Inc. Treatment planning systems and methods for body contouring applications
US8485861B2 (en) 2008-10-31 2013-07-16 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
WO2010065616A1 (en) * 2008-12-02 2010-06-10 Thermocure, Inc. Systems and methods for delivery of a breathing gas with fine ice particles
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
CA2749978A1 (en) 2009-01-20 2010-07-29 F. Hoffmann-La Roche Ag Cryogenic container
CN102307545B (zh) 2009-02-06 2016-06-15 泰克里斯公司 用于两相混合物的混合器
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US20100249753A1 (en) 2009-02-25 2010-09-30 Gaisser David M Vented syringe system and method for the containment, mixing and ejection of wetted particulate material
US7963939B2 (en) 2009-04-24 2011-06-21 Thomas Chun Syringe having extended blending path
CA2760610C (en) 2009-04-30 2017-09-19 Zeltiq Aesthetics, Inc. Device, system and method of removing heat from subcutaneous lipid-rich cells
CN102802717A (zh) * 2009-06-19 2012-11-28 贝尼奇尔股份有限公司 用于使鼻腔降温的设备
US20140200511A1 (en) 2009-10-30 2014-07-17 Searete Llc Systems, devices, and methods for making or administering frozen particles
WO2011091293A1 (en) 2010-01-21 2011-07-28 Zeltiq Aesthetics, Inc. Compositions for use with a system for improved cooling of subcutaneous lipid-rich tissue
JP2013517897A (ja) 2010-01-25 2013-05-20 ゼルティック エステティックス インコーポレイテッド 熱を皮下多脂質細胞から相変化冷却剤を介して非侵襲的に除去するための家庭用アプリケータ及びそれと関連した装置、システム及び方法
US9033965B2 (en) * 2010-02-01 2015-05-19 Boston Scientific Scimed, Inc. Nested balloon cryotherapy
US9980765B2 (en) 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
US9629745B2 (en) * 2010-02-16 2017-04-25 The Johns Hopkins University Method and device for non-invasive anatomical and systemic cooling and neuroprotection
US8950207B2 (en) 2010-03-30 2015-02-10 Hyper Wear, Inc. Device for stimulating adaptive thermogenesis in brown adipose tissue
WO2011156497A2 (en) 2010-06-08 2011-12-15 NanoICE, Inc. Ultra-small ice, uses thereof and apparatus for production
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
JP5934211B2 (ja) 2010-08-19 2016-06-15 シネロン メディカル リミテッド 個人美容皮膚治療のための電磁気エネルギーアプリケーター
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US10722395B2 (en) 2011-01-25 2020-07-28 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
EP2667811B1 (en) 2011-01-27 2015-12-30 Cryosa, Llc Apparatus for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US20120203312A1 (en) * 2011-02-05 2012-08-09 Rachel Elizabeth Batzer Surgical cooling device
US8690934B2 (en) 2011-05-09 2014-04-08 The Invention Science Fund I, Llc Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
WO2013021380A1 (en) 2011-08-09 2013-02-14 Syneron Beauty Ltd. A method and apparatus for cosmetic skin care
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
EP2753273B1 (en) 2011-09-05 2019-05-01 Qool Therapeutics, Inc. Gastric or peritoneal delivery of frozen mist to induce therapeutic hyperthermia
JP6046158B2 (ja) 2011-11-16 2016-12-14 ザ ジェネラル ホスピタル コーポレイション 皮膚組織の低温処置のための方法及び装置
KR102251171B1 (ko) 2011-11-16 2021-05-13 더 제너럴 하스피탈 코포레이션 피부 조직의 극저온 처리를 위한 방법 및 장치
US9458505B2 (en) 2011-12-20 2016-10-04 The Cleveland Clinic Foundation Diagnosis of cowden and cowden-like syndrome by detection of decreased killin expression
ES2421545B1 (es) 2012-02-01 2014-06-25 Universitat Polit�Cnica De Catalunya Dispositivo de dosificación e inyección de cementos óseos
JP2015097548A (ja) * 2012-03-09 2015-05-28 テルモ株式会社 バルーンカテーテル
IL219477A0 (en) 2012-04-30 2012-07-31 Berger Thermal Res Ltd A method for coupling between catheter tip and tissue by icing their interface and apparatus therefor
EP2668988B1 (en) 2012-05-30 2018-11-07 ARKRAY, Inc. Channel bubble reduction device, channel bubble reduction program, channel bubble reduction method, liquid provision device and chromatography device
WO2013181667A1 (en) 2012-06-01 2013-12-05 Cibiem, Inc. Percutaneous methods and devices for carotid body ablation
EP2872222B1 (en) 2012-07-06 2023-05-31 The General Hospital Corporation Method and apparatus for dermatological treatment
WO2014046552A1 (en) 2012-09-20 2014-03-27 Graham Brewster Ice slurry delivery system and components thereof
JP5926392B2 (ja) 2012-09-25 2016-05-25 株式会社キーレックス 溶接装置
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
EP2914186B1 (en) 2012-11-05 2019-03-13 Relievant Medsystems, Inc. Systems for creating curved paths through bone and modulating nerves within the bone
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
CN103110473A (zh) 2013-03-17 2013-05-22 广州市绿乔生物科技有限公司 一种散寒除湿保健袋及其使用方法
US20140303608A1 (en) 2013-04-08 2014-10-09 Scientific Image Center Management, Inc. System and method for providing treatment feedback for a thermal treatment device
CN105473089A (zh) 2013-06-05 2016-04-06 麦特文申公司 靶标神经纤维的调节
US9456861B2 (en) 2013-06-24 2016-10-04 Nordson Corporation Dispensing assembly having mixing and plunging assembly, and related methods
US10406021B2 (en) 2013-08-05 2019-09-10 Yue Wu Method and system for producing and delivering airless medical ice slurry to induce hypothermia
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
WO2015117036A2 (en) 2014-01-30 2015-08-06 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for improving the appearance of skin and providing for other treatments
EP3119356B1 (en) 2014-03-21 2019-03-20 The University of Western Ontario Mammalian head cooling system
US9550028B2 (en) 2014-05-06 2017-01-24 Biomet Biologics, LLC. Single step desiccating bead-in-syringe concentrating device
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
WO2016033374A1 (en) 2014-08-27 2016-03-03 Tva Medical, Inc. Cryolipopysis devices and methods therefor
WO2016033384A1 (en) 2014-08-28 2016-03-03 The General Hospital Corporation Injectable slurries and methods of manufacturing and using the same
US20160081974A1 (en) 2014-09-18 2016-03-24 Research & Business Foundation Sungkyunkwan University Composition for preventing or treating edema containing flavonoid compound
US20160089550A1 (en) 2014-09-25 2016-03-31 Zeltiq Aesthetics, Inc. Treatment systems, methods, and apparatuses for altering the appearance of skin
WO2016054165A1 (en) 2014-10-01 2016-04-07 Novocor Medical Systems, Inc. Fluid cooling devices, systems and methods for cooling fluids
US11534335B2 (en) 2014-10-01 2022-12-27 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
EP3012761B1 (de) 2014-10-20 2021-09-08 dSPACE digital signal processing and control engineering GmbH Schutz von softwaremodellen
CN105640706A (zh) 2014-11-14 2016-06-08 湖北文理学院 冷敷创可贴
WO2017062471A1 (en) 2015-10-05 2017-04-13 C Change Surgical Llc Use of sterile sleeve in production of surgical slush
JP2017536187A (ja) 2014-12-03 2017-12-07 メタベンション インコーポレイテッド 神経または他の組織を調節するためのシステムおよび方法
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
CN107530187B (zh) 2015-02-23 2020-06-30 库尔诊疗公司 用于冷冻颗粒的气管内递送的系统
US9855317B2 (en) 2015-04-27 2018-01-02 Reflex Medical, Inc. Systems and methods for sympathetic cardiopulmonary neuromodulation
WO2017070112A1 (en) 2015-10-19 2017-04-27 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
EP4324404A3 (en) 2016-01-13 2024-04-24 The General Hospital Corporation DBA Massachusetts Systems and methods for removing exogenous particles from the skin of a patient
SG10201913504XA (en) 2016-02-26 2020-03-30 Massachusetts Gen Hospital Medical ice slurry production and delivery systems and methods
BR112018073275A2 (pt) 2016-05-10 2020-10-27 Zeltiq Aesthetics, Inc sistema e método cosmético para congelar previsivelmente a pele do indivíduo, método cosmético para tratar a pele e método cosmético para tratar tecido alvo de um indivíduo
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
KR20200020657A (ko) 2016-11-02 2020-02-26 크리스토퍼 제이 피 벨리스 슬러리 생성을 위한 디바이스 및 방법
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
WO2018160797A1 (en) 2017-03-01 2018-09-07 Arctic Fox Biomedical, Inc. Cryotherapies
AU2018249540A1 (en) 2017-04-05 2019-10-31 Miraki Innovation Think Tank Llc Cold slurry containment
MX2019011995A (es) 2017-04-05 2020-01-20 Miraki Innovation Think Tank Llc Generación de una suspensión fría en un punto de suministro.
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
AU2019250128A1 (en) 2018-10-15 2020-04-30 Avent Inc. Compositions, systems, kits, and methods for neural ablation
US20200114041A1 (en) 2018-10-15 2020-04-16 Avent, Inc. Systems and methods for delivering a polymeric material to a treatment site during a radio frequency ablation procedure

Also Published As

Publication number Publication date
IL269857A (en) 2019-11-28
ZA201907138B (en) 2024-02-28
JP2020516357A (ja) 2020-06-11
US20180289537A1 (en) 2018-10-11
EP3606482A4 (en) 2021-01-06
BR112019020971A8 (pt) 2022-11-16
WO2018187573A1 (en) 2018-10-11
CN110868968A (zh) 2020-03-06
BR112019020971A2 (pt) 2020-05-05
CA3059294A1 (en) 2018-10-11
SG11201909303TA (en) 2019-11-28
US11439532B2 (en) 2022-09-13
EP3606482A1 (en) 2020-02-12
AU2018250270A1 (en) 2019-10-31
KR20200017385A (ko) 2020-02-18
JP2023120453A (ja) 2023-08-29

Similar Documents

Publication Publication Date Title
ZA201907138B (en) Point of delivery cold slurry generation
ZA202004557B (en) Modulatory polynucleotides
ZA201905488B (en) Tigit- and light-based chimeric proteins
MX2023010042A (es) Polinucleotidos moduladores.
MX2022003698A (es) Composiciones de nanoparticulas y metodos para inmunoterapia.
PH12016501680B1 (en) Anti-egfrviii antibodies and uses thereof
EP3800248A3 (en) Crispr-cas-related methods, compositions and components for cancer immunotherapy
MX2019001471A (es) Anticuerpos anti-siglec-7 para el tratamiento del cancer.
TW201613648A (en) Compounds and compositions for immunotherapy
PH12017501077A1 (en) Compositions and methods for antibodies targeting bmp6
MX2020004073A (es) Procesos de siembra en serie y usos de los mismos.
MY191581A (en) Anti-pd-1 antibodies
PH12016502479A1 (en) Formulated receptor polypeptides and related methods
TN2016000472A1 (en) Igf-1r antibody-drug-conjugate and its use for the treatment of cancer.
NZ732211A (en) Combination immunotherapy approach for treatment of cancer
PH12017500002A1 (en) Anti-cdh6 antibody drug conjugates
EP4279041A3 (en) Compositions and treatment systems for improved cooling of lipid-rich tissue
MX2015012334A (es) Metodos y composiciones para el control de malezas.
MY192513A (en) Compositions and methods related to diagnosis of prostate cancer
MX2020012893A (es) Formulaciones de proteinas.
ZA202002951B (en) Albumin-binding prodrugs of auristatin e derivatives
ZA201803476B (en) Anti-cd22 antibody-maytansine conjugates and methods of use thereof
MY180844A (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
MX2022010827A (es) Composiciones de microesferas de gas encapsulado en lipidos y metodos relacionados.
MX2016003207A (es) Composiciones que comprenden colina y derivados de esta, usos de las composiciones y procesos para su preparacion.