MX2020002286A - Composicion para el tratamiento del cancer asociado con la infeccion del hpv. - Google Patents

Composicion para el tratamiento del cancer asociado con la infeccion del hpv.

Info

Publication number
MX2020002286A
MX2020002286A MX2020002286A MX2020002286A MX2020002286A MX 2020002286 A MX2020002286 A MX 2020002286A MX 2020002286 A MX2020002286 A MX 2020002286A MX 2020002286 A MX2020002286 A MX 2020002286A MX 2020002286 A MX2020002286 A MX 2020002286A
Authority
MX
Mexico
Prior art keywords
composition
hpv
cancer associated
hpv infection
treating cancer
Prior art date
Application number
MX2020002286A
Other languages
English (en)
Inventor
Young Kee Shin
Young Deug Kim
Hun Soon Jung
Deuk Ae Kim
Original Assignee
Enhancedbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enhancedbio Inc filed Critical Enhancedbio Inc
Publication of MX2020002286A publication Critical patent/MX2020002286A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención refiere a una composición para prevenir o tratar enfermedades asociadas con el virus del papiloma humano (HPV), y más concretamente, cáncer asociado con HPV, y aún más concretamente, cáncer cervical. La secuencia de nucleótidos de la presente invención, la secuencia en la que se modifica su base, y su combinación específica puede ser útil en una composición para tratar efectivamente enfermedades asociadas con la infección de HPV inhibiendo grandemente la expresión del gen E6/E7 de HPV tipo 16 o 18.
MX2020002286A 2012-08-02 2015-01-30 Composicion para el tratamiento del cancer asociado con la infeccion del hpv. MX2020002286A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020120084820A KR101520383B1 (ko) 2012-08-02 2012-08-02 Ｈｐｖ 감염과 관련된 암의 치료용 조성물

Publications (1)

Publication Number Publication Date
MX2020002286A true MX2020002286A (es) 2020-07-13

Family

ID=50028269

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015001428A MX2015001428A (es) 2012-08-02 2013-08-01 Composicion para el tratamiento del cancer asociado con la infeccion de hpv.
MX2020002286A MX2020002286A (es) 2012-08-02 2015-01-30 Composicion para el tratamiento del cancer asociado con la infeccion del hpv.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015001428A MX2015001428A (es) 2012-08-02 2013-08-01 Composicion para el tratamiento del cancer asociado con la infeccion de hpv.

Country Status (13)

Country Link
US (3) US9719093B2 (es)
EP (6) EP3699279A1 (es)
JP (4) JP2015529654A (es)
KR (1) KR101520383B1 (es)
CN (1) CN104884096B (es)
AU (1) AU2013297196B2 (es)
BR (1) BR112015002177B1 (es)
CA (2) CA2880777C (es)
ES (1) ES2851904T3 (es)
MX (2) MX2015001428A (es)
RU (2) RU2636003C2 (es)
UA (1) UA117563C2 (es)
WO (1) WO2014021667A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105505929A (zh) * 2014-09-26 2016-04-20 中國香港貝億生物科技有限公司 针对hpv16e6基因的小干扰rna及其应用
KR20170139055A (ko) * 2015-04-16 2017-12-18 에이비온 주식회사 백금계 항암제에 의해 유도된 세포 내 증가된 p53 수준을 유지시키는 방법 및 이의 활용
KR20160133293A (ko) * 2015-05-12 2016-11-22 에이비온 주식회사 Hpv 바이러스의 발암 유전자 발현 저해물질을 유효성분으로 포함하는 암세포 감작용 조성물

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Publication number Publication date
JP2018109058A (ja) 2018-07-12
RU2636003C2 (ru) 2017-11-17
CA2880777C (en) 2020-06-30
CA3075050C (en) 2022-05-17
UA117563C2 (uk) 2018-08-27
US20170198291A1 (en) 2017-07-13
EP3757213A1 (en) 2020-12-30
EP2881123A1 (en) 2015-06-10
EP3722425A1 (en) 2020-10-14
EP3699278A1 (en) 2020-08-26
RU2015106855A (ru) 2016-09-27
US9719093B2 (en) 2017-08-01
US20180044679A1 (en) 2018-02-15
EP2881123A4 (en) 2016-07-06
KR20140018560A (ko) 2014-02-13
MX2015001428A (es) 2016-01-20
CN104884096B (zh) 2022-05-24
CA2880777A1 (en) 2014-02-06
AU2013297196B2 (en) 2017-01-05
ES2851904T3 (es) 2021-09-09
JP6727381B2 (ja) 2020-07-22
JP2019194234A (ja) 2019-11-07
US10221418B2 (en) 2019-03-05
US20150299711A1 (en) 2015-10-22
JP2016190845A (ja) 2016-11-10
AU2013297196A1 (en) 2015-03-19
EP3178498A3 (en) 2017-09-27
JP2015529654A (ja) 2015-10-08
KR101520383B1 (ko) 2015-05-15
EP3178498B1 (en) 2020-11-18
CA3075050A1 (en) 2014-02-06
WO2014021667A1 (ko) 2014-02-06
EP3699279A1 (en) 2020-08-26
JP6347433B2 (ja) 2018-06-27
BR112015002177B1 (pt) 2022-09-27
RU2664466C1 (ru) 2018-08-17
EP3178498A2 (en) 2017-06-14
BR112015002177A2 (pt) 2017-11-07
CN104884096A (zh) 2015-09-02

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