MX2020002882A - Fosforamiditas de nucleósido modificado. - Google Patents

Fosforamiditas de nucleósido modificado.

Info

Publication number
MX2020002882A
MX2020002882A MX2020002882A MX2020002882A MX2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A
Authority
MX
Mexico
Prior art keywords
nucleoside modified
modified phosphoramidites
phosphoramidites
nucleoside
formulae
Prior art date
Application number
MX2020002882A
Other languages
English (en)
Inventor
Sergei Gryaznov
Jin Hong
Vivek Kumar Rajwanshi
Original Assignee
Janssen Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biopharma Inc filed Critical Janssen Biopharma Inc
Publication of MX2020002882A publication Critical patent/MX2020002882A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción se relaciona con compuestos y composiciones que contienen monómeros de nucleósidos de 5'-fosforamidita de las Fórmulas (I) y (II), y métodos para elaborarlos y usarlos, en donde los sustituyentes son como se definen en las reivindicaciones anexas.
MX2020002882A 2017-09-14 2018-09-14 Fosforamiditas de nucleósido modificado. MX2020002882A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762558763P 2017-09-14 2017-09-14
PCT/IB2018/057077 WO2019053659A1 (en) 2017-09-14 2018-09-14 PHOSPHORAMIDITES OF MODIFIED NUCLEOSIDES

Publications (1)

Publication Number Publication Date
MX2020002882A true MX2020002882A (es) 2020-10-05

Family

ID=63713969

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020002882A MX2020002882A (es) 2017-09-14 2018-09-14 Fosforamiditas de nucleósido modificado.
MX2024007821A MX2024007821A (es) 2017-09-14 2020-03-13 Fosforamiditas de nucleosido modificado.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024007821A MX2024007821A (es) 2017-09-14 2020-03-13 Fosforamiditas de nucleosido modificado.

Country Status (15)

Country Link
US (3) US11180524B2 (es)
EP (1) EP3681894A1 (es)
JP (2) JP7478660B2 (es)
KR (1) KR20200100033A (es)
CN (1) CN111465610A (es)
AU (1) AU2018332214B2 (es)
CA (1) CA3075718A1 (es)
CL (2) CL2020000657A1 (es)
EA (1) EA202090719A1 (es)
IL (2) IL273274B2 (es)
MX (2) MX2020002882A (es)
PH (1) PH12020550127A1 (es)
SG (1) SG11202002294VA (es)
UA (1) UA127737C2 (es)
WO (1) WO2019053659A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL273274B2 (en) * 2017-09-14 2023-12-01 Janssen Biopharma Llc Modified nucleoside phosphoramidites
CN114685560B (zh) * 2020-12-31 2024-05-14 沈阳药科大学 含哌啶骨架亚磷酰胺单体及寡聚核苷酸的合成和应用
AU2024349303A1 (en) * 2023-09-25 2026-04-23 Acurna Ltd. Modified nucleoside compound, and oligonucleotide prepared therefrom

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1317291C (zh) * 1999-09-10 2007-05-23 杰龙公司 寡核苷酸n3′→p5′硫代氨基磷酸酯,其合成及应用
US20020127598A1 (en) 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
JP4255227B2 (ja) * 2000-11-21 2009-04-15 武 今西 Ｎ３’−ｐ５’結合を有する２’，４’−ｂｎａオリゴヌクレオチド
ATE503014T1 (de) * 2003-11-04 2011-04-15 Geron Corp Rna-amidate und thioamidateur rnai
US8138330B2 (en) * 2006-09-11 2012-03-20 Sigma-Aldrich Co. Llc Process for the synthesis of oligonucleotides
US8541569B2 (en) * 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
EP2326656B1 (en) * 2008-09-06 2017-01-25 Chemgenes Corporation Rna synthesis - phosphoramidites for synthetic rna in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic rna at the 3' - end
WO2011133871A2 (en) * 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. 5'-end derivatives
RS67188B1 (sr) * 2016-01-11 2025-10-31 Innate Tumor Immunity Inc Ciklični dinukleotidi za lečenje stanja povezanih sa aktivnošću sting kao što je kancer
AU2017326372B2 (en) 2016-09-14 2023-12-07 Janssen Biopharma, Inc. Modified oligonucleotides and methods of use
IL273274B2 (en) * 2017-09-14 2023-12-01 Janssen Biopharma Llc Modified nucleoside phosphoramidites

Also Published As

Publication number Publication date
US11180524B2 (en) 2021-11-23
PH12020550127A1 (en) 2021-02-08
US12030907B2 (en) 2024-07-09
JP2024054157A (ja) 2024-04-16
AU2018332214A1 (en) 2020-04-02
CN111465610A (zh) 2020-07-28
KR20200100033A (ko) 2020-08-25
MX2024007821A (es) 2024-07-15
UA127737C2 (uk) 2023-12-20
CL2020000657A1 (es) 2020-10-23
AU2018332214B2 (en) 2023-11-02
AU2018332214A8 (en) 2021-10-07
US20200255468A1 (en) 2020-08-13
JP7478660B2 (ja) 2024-05-07
CA3075718A1 (en) 2019-03-21
BR112020005067A2 (pt) 2020-09-15
SG11202002294VA (en) 2020-04-29
IL303486A (en) 2023-08-01
JP2020533387A (ja) 2020-11-19
EA202090719A1 (ru) 2020-07-01
IL273274A (en) 2020-04-30
IL273274B1 (en) 2023-08-01
US12428441B2 (en) 2025-09-30
IL273274B2 (en) 2023-12-01
EP3681894A1 (en) 2020-07-22
CL2021000381A1 (es) 2021-07-02
US20240309040A1 (en) 2024-09-19
US20220048941A1 (en) 2022-02-17
WO2019053659A1 (en) 2019-03-21

Similar Documents

Publication Publication Date Title
MX2020001598A (es) Inhibidores selectivos de proteína arginina metiltransferasa 5 (prmt5).
ZA201802331B (en) Stable inoculant compositions and methods for producing same
PH12020550703A1 (en) Sulfonamide compounds and use thereof
CY1121468T1 (el) Συνδυασμος παραγωγων πυρρολο[2,3-d]πυριμιδινης με εναν ή περισσοτερους επιπροσθετους παραγοντες ως αναστολεις των σχετικων me janus (ιανος) kinασων (jak)
EA201791563A1 (ru) Замещенные нуклеозидные производные, полезные в качестве агентов против рака
TN2018000276A1 (en) Inhibitors of receptor-interacting protein kinase 1.
MX2019013645A (es) Inhibidores de quinasa y usos de los mismos.
JO3195B1 (ar) مشتقات أندوليزين جديدة, وطريقة تحضيرهم والتركيبات الصيدلانية التي تحتوي عليهم لعلاج السرطان
EA201892147A1 (ru) Бициклические соединения
MA38982A1 (fr) Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl
MX2015011779A (es) Nucleosidos biciclicos unidos en puente.
MY186547A (en) 4?-fluoro-2?-methyl substituted nucleoside derivatives
EA201591546A1 (ru) Мультивалентные и моновалентные мультиспецифические комплексы и их применение
MX2018007075A (es) Compuestos policiclicos como inhibidores de tirosina quinasa de bruton.
PH12018500151A1 (en) Compound targeting il-23a and b-cell activating factor (baff) and uses thereof
MX386700B (es) Inhibidores de la tirosina quinasa de bruton y metodos de su uso.
PH12017501539A1 (en) Disacetoxytubulysin h and analogs thereof
EA201892246A1 (ru) Производные аминотиазола, полученные в качестве противовирусных средств
MX2017014459A (es) Compuestos de tioeter como inhibidores de la nitrificacion.
MX392001B (es) Composiciones fertilizantes y métodos para hacer y utilizar las mismas.
MX2020006596A (es) Hidroxiisoxazolinas y derivados de estos.
PH12015502589A1 (en) 4`-azido, 3`-deoxy-3`-fluoro substituted nucleoside derivatives
PH12020550127A1 (en) Modified nucleoside phosphoramidites
EA201892376A1 (ru) Комбинированный состав трех противовирусных соединений
EA201992764A1 (ru) Пиридиновые и пиразиновые соединения