MX2020003204A - Metodos de inmunoterapia para pacientes cuyos tumores portan una carga mutacional alta de un gen pasajero. - Google Patents

Metodos de inmunoterapia para pacientes cuyos tumores portan una carga mutacional alta de un gen pasajero.

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Publication number
MX2020003204A
MX2020003204A MX2020003204A MX2020003204A MX2020003204A MX 2020003204 A MX2020003204 A MX 2020003204A MX 2020003204 A MX2020003204 A MX 2020003204A MX 2020003204 A MX2020003204 A MX 2020003204A MX 2020003204 A MX2020003204 A MX 2020003204A
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Mexico
Prior art keywords
immunotherapy
cancer patient
gene
passenger gene
passenger
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MX2020003204A
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English (en)
Inventor
Wei Keat Lim
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Regeneron Pharma
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Publication date
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Publication of MX2020003204A publication Critical patent/MX2020003204A/es

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Abstract

Los métodos para seleccionar un paciente con cáncer para la inmunoterapia comprenden establecer una carga mutacional total del gen pasajero a partir de un tumor de un paciente de cáncer, generar una distribución de fondo para la carga mutacional del tumor, normalizar la carga mutacional total del gen pasajero contra la distribución de fondo, y categorizar al paciente de cáncer como un respondedor de inmunoterapia cuando la carga mutacional total del gen pasajero es mayor de la desviación estándar que la media de la distribución de fondo. Cuando el paciente con cáncer es un respondedor de inmunoterapia, puede administrarse al paciente un régimen de inmunoterapia que comprende activación/inhibición de receptores de células T que promueven la activación de células T y/o actividades citolíticas inmunitarias prolongadas.
MX2020003204A 2017-09-20 2018-09-19 Metodos de inmunoterapia para pacientes cuyos tumores portan una carga mutacional alta de un gen pasajero. MX2020003204A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762560955P 2017-09-20 2017-09-20
PCT/US2018/051755 WO2019060418A1 (en) 2017-09-20 2018-09-19 IMMUNOTHERAPY METHODS FOR PATIENTS WITH TUMORS TRANSPORTING HIGH PASSENGER GENE MUTATION CHARGE

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MX2020003204A true MX2020003204A (es) 2020-07-20

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US (3) US11640848B2 (es)
EP (2) EP3684955A1 (es)
JP (4) JP2020536051A (es)
KR (4) KR20200059243A (es)
CN (3) CN111133115A (es)
AU (3) AU2018336785B2 (es)
CA (1) CA3075927A1 (es)
IL (2) IL325919A (es)
MA (1) MA50271A (es)
MX (1) MX2020003204A (es)
RU (1) RU2020113600A (es)
SG (1) SG11202002282TA (es)
UA (1) UA128674C2 (es)
WO (1) WO2019060418A1 (es)
ZA (2) ZA202306801B (es)

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