MX2020004348A - Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). - Google Patents
Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc).Info
- Publication number
- MX2020004348A MX2020004348A MX2020004348A MX2020004348A MX2020004348A MX 2020004348 A MX2020004348 A MX 2020004348A MX 2020004348 A MX2020004348 A MX 2020004348A MX 2020004348 A MX2020004348 A MX 2020004348A MX 2020004348 A MX2020004348 A MX 2020004348A
- Authority
- MX
- Mexico
- Prior art keywords
- mtc
- methods
- chemical synthesis
- compounds including
- methylthioninium chloride
- Prior art date
Links
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960000907 methylthioninium chloride Drugs 0.000 title abstract 2
- KPYHKEZPEDJERZ-UHFFFAOYSA-N 10h-phenothiazine-1,2-diamine Chemical class C1=CC=C2NC3=C(N)C(N)=CC=C3SC2=C1 KPYHKEZPEDJERZ-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- CBBMGBGDIPJEMI-UHFFFAOYSA-N thionine cation Chemical class C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 CBBMGBGDIPJEMI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/38—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/02—Thiosulfates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporcionan métodos para sintetizar y purificar ciertos compuestos de 3,7-diamino-fenotiazin-5-io (referidos en la presente como "compuestos de diaminofenotiazinio") que incluyen cloruro de metiltioninio (MTC)/también conocido como Azul de Metileno).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317702.7A GB201317702D0 (en) | 2013-10-07 | 2013-10-07 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| PCT/GB2014/053007 WO2015052496A1 (en) | 2013-10-07 | 2014-10-06 | Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2020004348A true MX2020004348A (es) | 2021-03-22 |
| MX380797B MX380797B (es) | 2025-03-12 |
Family
ID=49630291
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004348A MX380797B (es) | 2013-10-07 | 2014-10-06 | Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
| MX2016004229A MX363102B (es) | 2013-10-07 | 2014-10-06 | Metodos de sintesis quimica de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
| MX2019002620A MX373105B (es) | 2013-10-07 | 2014-10-06 | Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016004229A MX363102B (es) | 2013-10-07 | 2014-10-06 | Metodos de sintesis quimica de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
| MX2019002620A MX373105B (es) | 2013-10-07 | 2014-10-06 | Métodos de síntesis química de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (mtc). |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9765042B2 (es) |
| EP (3) | EP4032880A3 (es) |
| JP (1) | JP6505091B2 (es) |
| CN (3) | CN110092764B (es) |
| AU (3) | AU2014333610B2 (es) |
| CA (3) | CA3207522A1 (es) |
| DK (2) | DK3055291T3 (es) |
| ES (2) | ES2903529T3 (es) |
| GB (1) | GB201317702D0 (es) |
| HR (2) | HRP20220102T1 (es) |
| MX (3) | MX380797B (es) |
| MY (3) | MY200569A (es) |
| PL (2) | PL3415505T3 (es) |
| PT (2) | PT3055291T (es) |
| SG (3) | SG10201913293PA (es) |
| SI (2) | SI3055291T1 (es) |
| TR (1) | TR201902152T4 (es) |
| TW (2) | TWI675829B (es) |
| WO (1) | WO2015052496A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130926B (zh) * | 2015-07-31 | 2018-02-13 | 江苏恒润制药有限公司 | 一种亚甲基蓝的制备方法 |
| GB201621817D0 (en) | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| US12215234B2 (en) * | 2019-09-21 | 2025-02-04 | RK Pharma Solutions LLC | Process for the purification of methylene blue |
| CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US204796A (en) | 1878-06-11 | Improvement in the production of dye-stuffs from methyl-aniline | ||
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| US4212971A (en) * | 1979-03-08 | 1980-07-15 | American Cyanamid Company | Process for preparing methylene blue |
| CH640146A5 (de) * | 1979-05-14 | 1983-12-30 | Meyer Maschinenfabrik Ag | Filtrationsverfahren. |
| US5344928A (en) | 1991-04-26 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Phenothiazine derivatives, their production and use |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| WO1998031219A1 (en) | 1997-01-21 | 1998-07-23 | The American National Red Cross | Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light |
| FR2810318B1 (fr) | 2000-06-15 | 2005-09-23 | Laurent Galey | Derives de diamano-phenothiazine |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB2373787A (en) | 2001-03-08 | 2002-10-02 | Univ Central Lancashire | Phenothiazinium derivatives and their use to reduce pathogenic contaminants |
| WO2006032879A2 (en) * | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| DK2853293T3 (en) * | 2006-03-29 | 2018-01-22 | Wista Lab Ltd | Thioninium compounds and their use |
| DK2004155T3 (en) * | 2006-03-29 | 2018-04-30 | Wista Lab Ltd | PROTEIN AGGREGATION INHIBITORS |
| MY162313A (en) * | 2006-07-11 | 2017-05-31 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| CN100436431C (zh) * | 2006-12-15 | 2008-11-26 | 贵州同济堂制药有限公司 | 药用亚甲蓝的合成方法 |
| DK2430007T3 (da) * | 2009-05-12 | 2014-05-12 | Wista Lab Ltd | Fremgangsmåde for kemisk syntese af diaminophenothiazinium forbindelser ved anvendelse af persulfat oxidanter |
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2013
- 2013-10-07 GB GBGB1317702.7A patent/GB201317702D0/en not_active Ceased
-
2014
- 2014-10-06 TW TW107113518A patent/TWI675829B/zh active
- 2014-10-06 US US15/027,400 patent/US9765042B2/en active Active
- 2014-10-06 TW TW103134782A patent/TWI626237B/zh active
- 2014-10-06 CN CN201910293813.7A patent/CN110092764B/zh active Active
- 2014-10-06 CA CA3207522A patent/CA3207522A1/en active Pending
- 2014-10-06 PL PL18181405T patent/PL3415505T3/pl unknown
- 2014-10-06 HR HRP20220102TT patent/HRP20220102T1/hr unknown
- 2014-10-06 MX MX2020004348A patent/MX380797B/es unknown
- 2014-10-06 CN CN202310997777.9A patent/CN117209450A/zh active Pending
- 2014-10-06 EP EP21203620.6A patent/EP4032880A3/en not_active Withdrawn
- 2014-10-06 CN CN201480054610.8A patent/CN105683171B/zh active Active
- 2014-10-06 ES ES18181405T patent/ES2903529T3/es active Active
- 2014-10-06 AU AU2014333610A patent/AU2014333610B2/en not_active Ceased
- 2014-10-06 MY MYPI2020004692A patent/MY200569A/en unknown
- 2014-10-06 ES ES14789349T patent/ES2713324T3/es active Active
- 2014-10-06 SI SI201431094T patent/SI3055291T1/sl unknown
- 2014-10-06 PT PT14789349T patent/PT3055291T/pt unknown
- 2014-10-06 TR TR2019/02152T patent/TR201902152T4/tr unknown
- 2014-10-06 MX MX2016004229A patent/MX363102B/es unknown
- 2014-10-06 SI SI201431945T patent/SI3415505T1/sl unknown
- 2014-10-06 SG SG10201913293PA patent/SG10201913293PA/en unknown
- 2014-10-06 WO PCT/GB2014/053007 patent/WO2015052496A1/en not_active Ceased
- 2014-10-06 MY MYPI2020004693A patent/MY200570A/en unknown
- 2014-10-06 EP EP14789349.9A patent/EP3055291B1/en active Active
- 2014-10-06 EP EP18181405.4A patent/EP3415505B1/en active Active
- 2014-10-06 CA CA3131803A patent/CA3131803C/en active Active
- 2014-10-06 PL PL14789349T patent/PL3055291T3/pl unknown
- 2014-10-06 JP JP2016520050A patent/JP6505091B2/ja active Active
- 2014-10-06 MY MYPI2016701234A patent/MY177815A/en unknown
- 2014-10-06 HR HRP20190374TT patent/HRP20190374T1/hr unknown
- 2014-10-06 PT PT181814054T patent/PT3415505T/pt unknown
- 2014-10-06 SG SG10201907363Y patent/SG10201907363YA/en unknown
- 2014-10-06 SG SG11201602650XA patent/SG11201602650XA/en unknown
- 2014-10-06 DK DK14789349.9T patent/DK3055291T3/en active
- 2014-10-06 CA CA2925801A patent/CA2925801C/en active Active
- 2014-10-06 DK DK18181405.4T patent/DK3415505T3/da active
- 2014-10-06 MX MX2019002620A patent/MX373105B/es active IP Right Grant
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2017
- 2017-07-17 AU AU2017206141A patent/AU2017206141B2/en not_active Ceased
- 2017-08-10 US US15/674,229 patent/US10047062B2/en active Active
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2018
- 2018-07-20 US US16/040,964 patent/US10421733B2/en active Active
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2019
- 2019-05-17 AU AU2019203490A patent/AU2019203490B2/en active Active
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