MX2020004902A - Derivados del acido oxoacridinilo acetico y metodos de uso. - Google Patents

Derivados del acido oxoacridinilo acetico y metodos de uso.

Info

Publication number
MX2020004902A
MX2020004902A MX2020004902A MX2020004902A MX2020004902A MX 2020004902 A MX2020004902 A MX 2020004902A MX 2020004902 A MX2020004902 A MX 2020004902A MX 2020004902 A MX2020004902 A MX 2020004902A MX 2020004902 A MX2020004902 A MX 2020004902A
Authority
MX
Mexico
Prior art keywords
methods
oxoacridinyl
acetic acid
acid derivatives
sting
Prior art date
Application number
MX2020004902A
Other languages
English (en)
Inventor
Sharon Shechter
Brian T Chamberlain
James M Rice
Iii Finith E Jernigan
Woody Sherman
Meghana M Kulkarni
Bryce K Allen
Dazhi Tan
Kristen A Marino
Lin Zhixiong
Original Assignee
Silicon Swat Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silicon Swat Inc filed Critical Silicon Swat Inc
Publication of MX2020004902A publication Critical patent/MX2020004902A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se proporcionan Compuestos de Fórmula I o sales o ésteres farmacéuticamente aceptables de los mismos capaces de unirse y modular la actividad de la proteína estimuladora de genes de interferón (STING). También se proporcionan métodos que implican compuestos de Fórmula I como moduladores efectivos de STING.
MX2020004902A 2017-11-20 2018-11-20 Derivados del acido oxoacridinilo acetico y metodos de uso. MX2020004902A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762588820P 2017-11-20 2017-11-20
US201862631530P 2018-02-16 2018-02-16
US201862723660P 2018-08-28 2018-08-28
PCT/US2018/062021 WO2019100061A1 (en) 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use

Publications (1)

Publication Number Publication Date
MX2020004902A true MX2020004902A (es) 2020-09-09

Family

ID=66540425

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004902A MX2020004902A (es) 2017-11-20 2018-11-20 Derivados del acido oxoacridinilo acetico y metodos de uso.

Country Status (13)

Country Link
US (2) US10745358B2 (es)
EP (1) EP3713920A4 (es)
JP (1) JP7323539B2 (es)
KR (1) KR20200100081A (es)
CN (1) CN111630036B (es)
AU (1) AU2018368789B2 (es)
BR (1) BR112020009592A2 (es)
CA (1) CA3079262A1 (es)
IL (1) IL274796A (es)
MX (1) MX2020004902A (es)
PH (1) PH12020550652A1 (es)
SG (1) SG11202004442VA (es)
WO (1) WO2019100061A1 (es)

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CN114302875A (zh) * 2019-05-16 2022-04-08 斯汀塞拉股份有限公司 氧代吖啶基乙酸衍生物及使用方法
AU2020291796B2 (en) * 2019-06-12 2024-01-18 Ryvu Therapeutics S.A. Next-generation modulators of stimulator of interferon genes (STING)
CN112442033A (zh) * 2019-08-28 2021-03-05 迈德欣国际有限公司 Sting通路调节剂及其用途
CN112624972A (zh) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 吖啶酮类化合物及医药用途
RU2730530C1 (ru) * 2019-10-29 2020-08-24 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Новое химическое соединение L-лизина 9-оксоакридинил-10-ацетат, стимулирующее продукцию интерлейкина-24 и фактора некроза опухолей - бета
CN116813647B (zh) * 2019-11-02 2025-08-01 上海凌达生物医药有限公司 一类含氮稠环类sting调节剂类化合物、制备方法和用途
CN111039849B (zh) * 2019-12-26 2021-07-06 阜阳欣奕华材料科技有限公司 一种含有咔唑环类化合物的制备方法
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Also Published As

Publication number Publication date
KR20200100081A (ko) 2020-08-25
PH12020550652A1 (en) 2021-04-26
AU2018368789B2 (en) 2022-06-02
JP2021503501A (ja) 2021-02-12
CN111630036B (zh) 2024-12-27
US20190161449A1 (en) 2019-05-30
SG11202004442VA (en) 2020-06-29
CA3079262A1 (en) 2019-05-23
US20230113570A1 (en) 2023-04-13
US10745358B2 (en) 2020-08-18
BR112020009592A2 (pt) 2020-11-03
CN111630036A (zh) 2020-09-04
EP3713920A4 (en) 2021-04-14
IL274796A (en) 2020-07-30
JP7323539B2 (ja) 2023-08-08
AU2018368789A1 (en) 2020-06-11
EP3713920A1 (en) 2020-09-30
WO2019100061A1 (en) 2019-05-23

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