MX2020005324A - Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos. - Google Patents
Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos.Info
- Publication number
- MX2020005324A MX2020005324A MX2020005324A MX2020005324A MX2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A
- Authority
- MX
- Mexico
- Prior art keywords
- acid
- gene
- coa
- modified microorganism
- polypeptide
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 title 2
- YVOMYDHIQVMMTA-UHFFFAOYSA-N 3-Hydroxyadipic acid Chemical compound OC(=O)CC(O)CCC(O)=O YVOMYDHIQVMMTA-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 235000011037 adipic acid Nutrition 0.000 title 1
- 239000001361 adipic acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 150000001413 amino acids Chemical group 0.000 abstract 4
- OTEACGAEDCIMBS-FOLKQPSDSA-N 3-hydroxyadipyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OTEACGAEDCIMBS-FOLKQPSDSA-N 0.000 abstract 3
- VKKKAAPGXHWXOO-BIEWRJSYSA-N 3-oxoadipyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VKKKAAPGXHWXOO-BIEWRJSYSA-N 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se describe un microorganismo modificado genéticamente en donde se introduce un ácido nucleico que codifica una enzima que cataliza una reacción que reduce el 3-oxoadipil-CoA a 3-hidroxidipil-CoA. En el microorganismo modificado genéticamente, se lleva a cabo una de las siguientes acciones: se introduce un ácido nucleico que codifica cualquiera de los polipéptidos descritos en (a) a (c) a continuación; o, se mejora la expresión del polipéptido: (a) un polipéptido compuesto por una secuencia de aminoácidos representada por cualquiera de las SEC. ID NO.: 1-6 y 213, (b) un polipéptido que comprende cualquiera de las secuencias de aminoácidos de las SEC. ID NO.: 1-6 y 213 en el cual al menos un aminoácido ha sido sustituido, eliminado, insertado y/o añadido, el polipéptido tiene actividad enzimática que cataliza una reacción que reduce el 3-oxoadipil-CoA a 3-hidroxiadipil-CoA, y (c) un polipéptido que tiene una identidad de la secuencia con cualquiera de las secuencias de aminoácidos de las SEC. ID NO.: 1-6 y 213, el polipéptido que tienen actividad que reduce el 3-oxoadipil- CoA a 3-hidroxiadipil-CoA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017230407 | 2017-11-30 | ||
| PCT/JP2018/044080 WO2019107516A1 (ja) | 2017-11-30 | 2018-11-29 | ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020005324A true MX2020005324A (es) | 2020-08-13 |
Family
ID=66665013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020005324A MX2020005324A (es) | 2017-11-30 | 2018-11-29 | Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12275979B2 (es) |
| EP (1) | EP3719121A4 (es) |
| JP (1) | JP7331691B2 (es) |
| CN (1) | CN111386339B (es) |
| BR (1) | BR112020010328A2 (es) |
| CA (1) | CA3083563A1 (es) |
| MX (1) | MX2020005324A (es) |
| WO (1) | WO2019107516A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12275979B2 (en) * | 2017-11-30 | 2025-04-15 | Toray Industries, Inc. | Gene-modified microorganism for producing 3-hydroxyadipic acid, alpha-hydromuconic acid, and/or adipic acid, and production method for said chemical products |
| EP3967763A4 (en) * | 2019-05-10 | 2024-01-03 | Toray Industries, Inc. | GENETICALLY MODIFIED MICROORGANISM FOR THE PRODUCTION OF 3-HYDROXYHEXANIC ACID, (E)-HEX-2-ENDIONIC ACID AND/OR HEXANEDIONIC ACID AND PRODUCTION PROCESS FOR THESE CHEMICALS |
| CN113785069A (zh) * | 2019-05-10 | 2021-12-10 | 东丽株式会社 | 用于生产3-羟基己二酸、α-氢化己二烯二酸和/或己二酸的基因修饰微生物以及该化学品的制造方法 |
| CN111484942A (zh) * | 2019-12-02 | 2020-08-04 | 江南大学 | 一种利用酿酒酵母生产己二酸的方法 |
| WO2021187533A1 (ja) * | 2020-03-18 | 2021-09-23 | 東レ株式会社 | ３－ヒドロキシアジピン酸および／またはα－ヒドロムコン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| WO2021230222A1 (ja) | 2020-05-12 | 2021-11-18 | 東レ株式会社 | 遺伝子改変微生物および有機酸の製造方法 |
| US20230392112A1 (en) * | 2020-11-11 | 2023-12-07 | Toray Industries, Inc. | Genetically modified microorganism for producing 3-hydroxyadipic acid and/or alpha-hydromuconic acid, and method for producing chemical product |
| EP4263688A4 (en) * | 2020-12-16 | 2025-11-05 | Alliance Sustainable Energy | UPWARD CARRYING OF MIXED PLASTIC WASTE BY CHEMICAL DEPOLYMERIZATION AND BIOLOGICAL FUNNEL FORMATION |
| JPWO2022181654A1 (es) * | 2021-02-25 | 2022-09-01 | ||
| EP4306515B1 (en) | 2021-03-12 | 2026-02-04 | Toray Industries, Inc. | 3-hydroxyadipic acid 3,6-lactone composition |
| US20250382643A1 (en) | 2022-02-15 | 2025-12-18 | Toray Industries, Inc. | GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC ACID AND/OR Alpha-HYDROXYADIPIC ACID, AND METHOD FOR PRODUCING CHEMICAL PRODUCT |
| WO2023182322A1 (ja) | 2022-03-23 | 2023-09-28 | 東レ株式会社 | ３－ヒドロキシアジピン酸および／または３－オキソアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| CN121057821A (zh) * | 2023-05-23 | 2025-12-02 | 东丽株式会社 | 用于生产3-羟基己二酸、α-氢化己二烯二酸和/或己二酸的基因修饰微生物以及该化学品的制造方法 |
| CN116904366B (zh) * | 2023-08-04 | 2024-06-25 | 西南大学 | 一种嗜线虫沙雷氏菌、微生物包衣制剂及其应用 |
| WO2025063258A1 (ja) * | 2023-09-21 | 2025-03-27 | 東レ株式会社 | α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| KR102901475B1 (ko) * | 2025-03-06 | 2025-12-19 | 한국화학연구원 | 3-옥소아디필-CoA 티올라제 효소 변이체 및 이를 이용한 아디프산 생산방법 |
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| US20110229942A1 (en) * | 2007-12-13 | 2011-09-22 | Glycos Biotechnologies, Incorporated | Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals |
| US9096873B2 (en) * | 2008-03-11 | 2015-08-04 | Genomatica, Inc. | Adipate (ester or thioester) synthesis |
| CN102066551B (zh) * | 2008-03-27 | 2013-10-09 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
| WO2011017560A1 (en) | 2009-08-05 | 2011-02-10 | Genomatica, Inc. | Semi-synthetic terephthalic acid via microorganisms that produce muconic acid |
| JP2011097929A (ja) * | 2009-10-09 | 2011-05-19 | Mitsui Chemicals Inc | イソプロピルアルコール生産酵母及びイソプロピルアルコール生産方法 |
| BR112013001635A2 (pt) | 2010-07-26 | 2016-05-24 | Genomatica Inc | micro-organismo e métodos para a biossíntese de aromáticos, 2, 4-pentadienoato e 1,3-butadieno |
| CN103562398A (zh) * | 2011-03-22 | 2014-02-05 | Opx生物工艺学公司 | 化学产品的微生物生产以及相关的组合物、方法和系统 |
| WO2014151645A1 (en) * | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
| CN103937841B (zh) * | 2014-05-13 | 2015-10-28 | 上海交通大学 | 烯酰辅酶a水合酶在己二酸生物合成中的应用 |
| US9988654B2 (en) * | 2014-06-16 | 2018-06-05 | Invista North America S.A.R.L. | Methods, reagents and cells for biosynthesizing compounds |
| RU2017101354A (ru) * | 2014-06-18 | 2018-07-18 | Торэй Индастриз, Инк. | Набор или устройство для обнаружения рака легкого и способ обнаружения |
| JP6332855B2 (ja) * | 2014-06-23 | 2018-05-30 | 花王株式会社 | アシル−ａｃｐチオエステラーゼを用いた脂質の製造方法 |
| EP3218505A1 (en) * | 2014-11-14 | 2017-09-20 | Invista Technologies S.à r.l. | Methods and materials for producing 6-carbon monomers |
| JP7127987B2 (ja) * | 2014-12-23 | 2022-08-30 | ジェノマティカ， インコーポレイテッド | ジアミンの製造および処理方法 |
| CN107614692B (zh) | 2015-06-10 | 2022-04-19 | 东丽株式会社 | α-氢化己二烯二酸的制造方法 |
| EP3309258B1 (en) | 2015-06-10 | 2020-06-03 | Toray Industries, Inc. | Method for producing 3-hydroxyadipic acid |
| MX391661B (es) | 2015-10-13 | 2025-03-21 | Lanzatech Nz Inc | Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía |
| EP3388525B1 (en) | 2015-12-11 | 2020-09-16 | Toray Industries, Inc. | Method for producing 3-oxoadipic acid by fermentation |
| JP6999090B2 (ja) * | 2016-05-31 | 2022-01-18 | 東レ株式会社 | ３－ヒドロキシアジピン酸の製造方法 |
| JP6948595B2 (ja) | 2016-05-31 | 2021-10-13 | 東レ株式会社 | α−ヒドロムコン酸の製造方法 |
| WO2018056794A1 (ko) * | 2016-09-26 | 2018-03-29 | 한국생명공학연구원 | 아세트산을 유일 탄소원으로 이용할 수 있는 미생물 |
| CN106834200B (zh) * | 2017-03-01 | 2020-02-18 | 江南大学 | 一种提高大肠杆菌中己二酸产量的方法 |
| CN108004275B (zh) * | 2017-11-16 | 2020-12-29 | 江南大学 | 一种产己二酸的大肠杆菌重组菌及其应用 |
| US12275979B2 (en) * | 2017-11-30 | 2025-04-15 | Toray Industries, Inc. | Gene-modified microorganism for producing 3-hydroxyadipic acid, alpha-hydromuconic acid, and/or adipic acid, and production method for said chemical products |
| KR20220023757A (ko) * | 2019-04-24 | 2022-03-02 | 게노마티카 인코포레이티드 | 알데하이드 데하이드로게나아제 활성을 개선하기 위한 조작된 미생물 및 방법 |
| EP3967763A4 (en) * | 2019-05-10 | 2024-01-03 | Toray Industries, Inc. | GENETICALLY MODIFIED MICROORGANISM FOR THE PRODUCTION OF 3-HYDROXYHEXANIC ACID, (E)-HEX-2-ENDIONIC ACID AND/OR HEXANEDIONIC ACID AND PRODUCTION PROCESS FOR THESE CHEMICALS |
| CN113785069A (zh) * | 2019-05-10 | 2021-12-10 | 东丽株式会社 | 用于生产3-羟基己二酸、α-氢化己二烯二酸和/或己二酸的基因修饰微生物以及该化学品的制造方法 |
| WO2021177900A1 (en) * | 2020-03-05 | 2021-09-10 | National University Of Singapore | Biosynthesis of commodity chemicals from oil palm empty fruit bunch lignin |
| WO2021187533A1 (ja) * | 2020-03-18 | 2021-09-23 | 東レ株式会社 | ３－ヒドロキシアジピン酸および／またはα－ヒドロムコン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| WO2021230222A1 (ja) * | 2020-05-12 | 2021-11-18 | 東レ株式会社 | 遺伝子改変微生物および有機酸の製造方法 |
| CN117441008A (zh) * | 2021-03-30 | 2024-01-23 | 旭化成株式会社 | 重组微生物和c6化合物的制造方法 |
| US20250382643A1 (en) * | 2022-02-15 | 2025-12-18 | Toray Industries, Inc. | GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC ACID AND/OR Alpha-HYDROXYADIPIC ACID, AND METHOD FOR PRODUCING CHEMICAL PRODUCT |
| WO2023182322A1 (ja) * | 2022-03-23 | 2023-09-28 | 東レ株式会社 | ３－ヒドロキシアジピン酸および／または３－オキソアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
-
2018
- 2018-11-29 US US16/766,979 patent/US12275979B2/en active Active
- 2018-11-29 CN CN201880076294.2A patent/CN111386339B/zh active Active
- 2018-11-29 MX MX2020005324A patent/MX2020005324A/es unknown
- 2018-11-29 BR BR112020010328-4A patent/BR112020010328A2/pt unknown
- 2018-11-29 EP EP18883299.2A patent/EP3719121A4/en active Pending
- 2018-11-29 WO PCT/JP2018/044080 patent/WO2019107516A1/ja not_active Ceased
- 2018-11-29 CA CA3083563A patent/CA3083563A1/en active Pending
- 2018-11-29 JP JP2019504865A patent/JP7331691B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200291435A1 (en) | 2020-09-17 |
| JP7331691B2 (ja) | 2023-08-23 |
| BR112020010328A2 (pt) | 2020-11-17 |
| CA3083563A1 (en) | 2019-06-06 |
| CN111386339A (zh) | 2020-07-07 |
| EP3719121A1 (en) | 2020-10-07 |
| US12275979B2 (en) | 2025-04-15 |
| EP3719121A4 (en) | 2021-12-15 |
| CN111386339B (zh) | 2024-05-10 |
| WO2019107516A1 (ja) | 2019-06-06 |
| JPWO2019107516A1 (ja) | 2020-10-08 |
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